High-dose intravenous gamma globulin in alloimmunized platelet transfusion recipients.
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Humans↗
Biomedical subjects
C Knupp
Publications and source records attributed to C Knupp.
Three-Dimensional Reconstruction of a Collagen IV Analogue in the Dogfish Egg Case Wall.
The wall of the egg case of the dogfish (Scyliorhinus canicula) contains an analogue of collagen Types IV and VIII organised into a regular 3-dimensional network. It presumably provides both a protective and a filtering role for the eggs contained within it. Electron micrographs of longitudinal and transverse sections, including systematically tilted sections, have been used both to define, for the first time, the space group symmetry of the lattice and to carry out 3-D reconstruction of the unit cell contents. This cell was found to be tetragonal, space group I422, with a = b = 11 ± 1 nm, and c = 74 ± 4 nm. Consistent with this, projection symmetries were c2mm for the [1,0,0] view, p2mm for the [1,1,0] view, and p4mm for the projection down the c axis (the [0,0,1] view), and all observed reflections in the computed Fourier transform obeyed the rule h + k + l = 2n (n integer) for body-centred lattices. The 3-D reconstruction, the first electron micrograph 3-D reconstruction of a collagen-containing material, is interpreted in terms of variations of previous molecular models for this structure. Type IV collagen is a constituent of the basal lamina, where it forms a network with both structural and filtering properties. The dogfish egg case structure may throw light on the (less regular) collagen IV structure of the basal lamina.
Journal Article↗
2',3'-Dideoxyinosine in patients with AIDS or AIDS-related complex.
Twenty-one patients with AIDS or AIDS-related complex (ARC) received 2',3'-dideoxyinosine (didanosine; ddI) intravenously and then orally (initial dosages of 0.4 mg/kg and 0.8 mg/kg every 12 hours, respectively) for 6-44 weeks in an escalating-dose study. The major dose-limiting effects were peripheral neuropathy (three patients) and pancreatitis (two patients), which were observed at dosages greater than or equal to 20 mg/(kg.d). Hyperuricemia occurred at greater than or equal to 30 mg/(kg.d). No hematologic toxicity developed except for possible sporadic thrombocytopenia (two patients). Significant decreases in serum levels of p24 antigen and increases in CD4+ and CD8+ lymphocytes were noted at 2, 6, and 10-20 weeks and over a wide range of dosages, including the lowest given. Most patients had an increased feeling of well-being and/or a weight gain of greater than or equal to 2 kg at 6 weeks. For this population, ddI has promise as a therapeutic agent, thus warranting further study of this agent in controlled clinical trials.
AIDS-Related Complex↗