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Biomedical subjects

C Kenyon

Publications and source records attributed to C Kenyon.

60 records · Page 4Linked to original sources
PubMed1986

Midazolam in conservative dentistry. A cross-over trial.

In a double-blind trial, 50 patients were randomly allocated to receive up to 0.29 mg/kg diazepam (Valium 5 mg/ml) or 0.14 mg/kg of midazolam (midazolam hydrochloride 5 mg/ml) intravenously at a first session of conservative dentistry, the alternative being administered at the second session. Good operating conditions were reported under each sedative and no important physiological differences were observed. Most patients failed to return to 'street fitness' 30 minutes after either session of treatment. Previous reports of reduced incidence of venous thrombophlebitis with midazolam were not convincingly confirmed in this trial, but data quality was poor. For about half the patients, the amnesic effect was stronger following midazolam.

Adolescent↗
PubMed1980

I.v. flunitrazepam and i.v. diazepam in conservative dentistry. A cross-over trial.

In a randomized cross-over trial in 82 outpatients aged 15-45 yr undergoing conservative dentistry, a solution of flunitrazepam 0.25 mg ml-1 i.v. (average dose 0.014 mg kg-1) was compared with a solution of diazepam 5 mg ml-1 i.v. (0.29 mg kg-1). Cardiovascular changes, operating conditions and side-effects were similar. Forty minutes after the start of injection, about 85% of all patients could not remember the local anaesthetic injection. Thirty minutes after the end of treatment, only 25% of all patients had recovered. One week later, most patients receiving each drug had only vague memories of their treatment; they had felt more relaxed immediately after the i.v. injection than before. Drowsiness was equally common after flunitrazepam and diazepam. Ataxia was more prolonged with flunitrazepam but arm pain and venous thrombophlebitis were less frequent.

Adolescent↗
PubMed1976

Subanaesthetic dosage of Althesin as a sedative for conservative dentistry. A controlled trial.

A randomized partial cross-over clinical trial of two intravenous techniques for outpatient conservative dentistry was performed in 61 patients. Subanaesthetic incremental doses of Althesin were used at 52 sessions and a single sedative dose of diazepam at 45 sessions. Each technique produced similar cardiovascular and respiratory changes. With Althesin, recovery after operation was more rapid and there was some evidence of a stronger anxiolytic effect and of less frequent and less severe thrombophlebitis. In contrast, Althesin was sometimes associated with jaw tremor or shivering and was less frequently mentioned by those patients who expressed a strong preference for one of the two techniques.

Adult↗
PubMedDate not supplied

From von Graefe's clinic to the Ecole des Beaux-Arts. The meteoric career of Richard Liebreich.

Richard Liebreich was a student of Helmholtz and took one of the first ophthalmoscopes to von Graefe's clinic. While von Graefe's assistant in Berlin, he created the first atlas of ophthalmoscopy. Liebreich moved to Paris, where he achieved great success, due in part to successful surgery on Emperor Napoleon III's mother-in-law. After the fall of Napoleon in 1870, Liebreich moved to London, where he became the head of ophthalmology at St. Thomas hospital and medical school. Following several personal attacks in the medical literature, Liebreich returned to Paris, where he gradually retired from practice, yet continued a creative life as a sculptor, painter, and researcher in artistic technique.

England↗
PubMedDate not supplied

Understanding valve/host interactions through explanted valve analysis.

It is essential that the factors leading to bioprosthetic valve dysfunction are fully understood if a more durable bioprosthesis is to be developed and the incidence of premature failure reduced. Studies of explanted bioprostheses yield important information on both the aetiology of valve failure and influence of valve/host interactions. Details are given of the Sheffield Explant Study which holds data on 570 explants and 34 different models. Advantages and disadvantages of this type of study are discussed.

Bioprosthesis↗