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Biomedical subjects

C Kaur

Publications and source records attributed to C Kaur.

82 records · Page 5Linked to original sources
PubMed1981

Antiandrogenic effects of cyproterone acetate and chloromadinone acetate on the rat hypothalamus as revealed by electroencephalographic responses.

Bipolar stainless steel electrodes were implanted stereotaxically into given hypothalamic and cortical regions of the brain of 48 rats. The animals were divided into two groups of equal numbers and the electrical activity of the given regions was recorded electroencephalographically (EEG). The effect of the acute and chronic administration of cyproterone acetate (CPA) or chloromadinone acetate (CHA), in doses inducing sterility, on EEG activity were observed. Apart from slight inhibition in the preoptic region, no appreciable EEG changes were found after CPA, while CHA reduced the discharge frequency in both the preoptic and the posterior hypothalamus. These findings can be attributed to the presence of two different types of androgen receptors in the hypothalamus.

Androgen Antagonists↗
PubMed1979

Synchronization of EEG activity of male Rhesus monkeys Macaca mulatta treated with ovocyclin.

Bipolar stainless steel electrodes were stereotaxically implanted in hypothalamus and cortex of six male monkeys. The effect of intramuscular injection of estradiol dipropionate (ovocyclin) in a dose of 10 mg/d was observed on EEG activity on 3 successive days. On the first day, slow waves appeared only in preoptic and on the second day also in posterior hypothalamus. Generalized slowing with an increase in amplitude appeared in all the hypothalamic areas and cortex on the third day. This suggest estrogen to possess (i) cumulative effect on brain and (ii) inhibitory action in the form of synchronization of EEG activity.

Animals↗
PubMed1978

1,2-Propanediol-induced changes in plasma and tissue lipids of rats.

Oral administration of 1,2-propanediol to rats in a daily dose of 1 ml of 28.4% aqueous solution per 100 g body weight for 30 days caused a significant decrease in the total lipids, fatty acids, phospholipids, and triglycerides of plasma, liver, and heart. The cholesterol content in plasma decreased while that in the tissues increased significantly. The accumulation of cholesterol in tissues tends to discourage long term use of 1,2-propanediol even by the oral route.

Animals↗
PubMed1973

New colorimetric method for the quantitative estimation of phospholipids without acid digestion.

A unique colorimetric method for the quantitative determination of phospholipids that does not involve the acid digestion of the lipid is described. The phospholipids, after separation by thin-layer chromatography and elution from the silica gel, are heated with a chromogenic solution that is a modification of a spray reagent formulated by Vaskovsky and Kostetsky (1968, J. Lipid Res., 9: 396). The absorbance of the colored complex was read at 710 nm, and it followed Beer's law in the range of 1-10 micro g of phospholipid phosphorus.

Chromatography, Thin Layer↗
PubMedDate not supplied

Effects of estradiol dipropionate on the biochemical composition of testis and accessory sex organs of adult rats.

A short term treatment of 14 days with estradiol dipropionate, ovocyclin¿ to adult male albino rats for 7 and 14 days in a dose of 2 mg/rat significantly inhibited the structural and functional integrity of the testis and accessory glands. The weights of these organs were significantly reduced. The activity of the enzymes acid and alkaline phosphatase and succinic dehydrogenase in testis and the concentration of sialic acids, fructose and citric acid in caput and cauda epididymides, prostate and seminal vesicles respectively were significantly lowered after both treatments. All these changes were found to be irreversible even on withdrawal of ovocyclin¿ for 28 days after 14 days treatment. On discussing the results with previous reports, it is proposed that estrogens probably impede the activity of these organs by inhibition of androgen production, their antiandrogenic nature or their direct action on these organs.

Androgen Antagonists↗
PubMedDate not supplied

Enhancement of ovulation by luteinizing hormone in cyclic albino rats.

Treatment of cyclic albino rats with equine luteinizing hormone (LH) on the afternoon of proestrus significantly enhanced ovulatory capacity. The number of ova shed and the healthy corpora lutea in the ovaries were significantly increased. Ovarian proteolytic enzymes also increased significantly with LH treatment. The histologically normal graafian follicles bound to become atretic in the vehicle-treated animals were altogether absent in the LH-treated rats on the day of estrus. These results indicate that LH enhances the number of ovulations by reducing the preovulatory follicles from atresia and facilitates their rupture by increasing the amount of proteolytic enzymes in them. A single injection of porcine follicle stimulating hormone (FSH), human chorionic gonadotrophin (hCG), and pregnant mare's serum gonadotrophin (PMSG) given separately was ineffective in inducing superovulation in cyclic albino rats.

Animals↗