Search PubMed⌕ Search

Biomedical subjects

C Kalifa

Publications and source records attributed to C Kalifa.

155 records · Page 9Linked to original sources
PubMed1982

Endocrine aspects and tumoral markers in intracranial germinoma: an attempt to delineate the diagnostic procedure in 14 patients.

This work outlines the endocrine abnormalities associated with intracranial germinomas (14 patients before treatment). Diabetes insipidus of various intensity was present in all cases. Adipsia is often present as well. In six patients, the first neuroradiologic examination after the onset of DI was normal. Growth hormone secretion was deficient in 11 of 13 patients. Abnormalities of TSH response to TRH were present in nine of ten (four insufficient and five exaggerated responses to TRH). Anterior pituitary dysfunction could not be predicted by the tumor site as determined by radiologic criteria. Tumoral markers have also been studied. Elevated plasma tumoral markers were found in four patients of 11 studied. Tumoral germinoma cells were present in CSF in five patients of ten, in one of them before radiologic confirmation. Pertinent endocrine evaluation and search for tumoral markers was of great value in systematic follow-up of patients with central diabetes insipidus, and could lead to early diagnosis and treatment of the tumor.

Adolescent↗
PubMed1982

[Thalamic tumors in children. A study of 38 cases (author's transl)].

The main clinical, evolutive and therapeutic features of thalamic tumors are reviewed in 38 children. Signs of increased intracranial pressure (76% of the cases) and of controlateral hemiparesis of varying degree (76% of the cases) were the main clinical symptoms. CT-scan is the best means of investigation. Therapeutic protocols that seem to obtain the best results consist of radiotherapy (between 45 and 55 grays) associated with shunting, when intracranial hypertension results from obstruction of an interventricular foramen by the tumor. Surgery is contra-indicated in most tumors in this area.

Adolescent↗
PubMed1981

[Optic glioma in children. A retrospective study of 57 cases treated by irradiation (author's transl)].

57 children presenting with optic glioma, 30 of which with neurofibromatosis, were treated from 1956 to 1978 at the Institute Gustave-Roussy. In 3, the tumor was confined to a single optic nerve; 18 had a chiasm-infiltrating tumor and 36 a large tumor invading adjacent structures. At the time of diagnosis, all but 2 had visual deficit, 5 had endocrine dysfunction and 27 had symptoms of increased intracranial pressure. X-ray examinations showed an enlargement of the sella turcica in 28 out of 37 patients and enlarged optic canals in 39 out of 41 investigated cases. 25 patients were operated on (most often exploratory operation only) and all received a 50 to 60 grays irradiation. 42 patients are alive but 20 are blind and 26 present with important mental retardation.

Adolescent↗
PubMed1981

[Choriocarcinoma in mother and child (author's transl)].

The case of a 2 month-old child with metastatic choriocarcinoma is reported. Death occurred rapidly and necropsy failed to find a primary tumor; the choriocarcinoma was therefore thought to be developed in the placenta. A year later, a uterine exploration was performed in the mother. In spite of normal chorionic gonadotrophin levels the histological findings were compatible with choriocarcinoma.

Choriocarcinoma↗
PubMedDate not supplied

Antiinfective prophylaxis with ceftazidime and teicoplanin in children undergoing high-dose chemotherapy and bone marrow transplantation.

Sixty children treated for solid tumors with high-dose chemotherapy followed by bone marrow transplantation were randomly assigned to one of two antibiotic protocols. Group A received prophylaxis consisting of ceftazidime plus teicoplanin beginning before the onset of aplasia and fever; group B received exactly the same antibiotic regimen but beginning at the onset of fever. The two groups were compared in terms of the rate of septicemia, fever of unknown origin, the time-lapse before the appearance of septicemia, the sensitivity of the causative organisms to the antibiotics, the effect of the latter on the intestinal flora, and the rate of fungal infections. The incidence of septicemia was significantly lower in group A (6.6%) than in group B (24.0%), mainly due to the prevention of episodes of early onset. Similarly, the appearance of the first episode of fever was delayed in group A, and the overall duration was reduced. Amphotericin B was prescribed empirically with the same rule in both groups, but three children in group A did not require amphotericin B. The effect on the intestinal flora was similar in the two groups; it must, however, be closely monitored so that the presence of potential pathogens can be dealt with appropriately.

Adolescent↗