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Biomedical subjects

C K Wallace

Publications and source records attributed to C K Wallace.

29 records · Page 2Linked to original sources
PubMed1968

Optimal antibiotic therapy in cholera.

Intravenous replacement of the diarrhoeal fluid and electrolyte losses to restore a physiological state of hydration is well established as the basis for successful management of cholera patients. The use of oral tetracycline as an adjunct in reducing the volume and duration of diarrhoea, as well as eradicating the vibrio from the gastrointestinal tract, has been proven beneficial. An optimal dose schedule has not been established previously, and clinical or bacteriological relapses have been generally reported. Chloramphenicol and sulfaguanidine have also been mentioned as adjuncts. The present report shows that 3 g or 4 g of tetracycline in one of 3 dose schedules were predictably efficacious. Chloramphenicol, while of benefit, was not as effective and sulfaguanidine was of little benefit compared with the tetracycline regimens.

Adolescent↗
PubMed1965

Clinical and physiological observations during an epidemic outbreak of non-vibrio cholera-like disease in Calcutta.

During March through June 1964, an epidemic of acute non-vibrio diarrhoeal disease, closely simulating cholera, occurred in Calcutta. To clarify the etiology and pathophysiology and improve the therapy of this illness, bacteriological and metabolic studies were performed on 145 consecutive hypotensive adult male patients admitted with acute diarrhoeal disease to the Calcutta Infectious Disease Hospital. Bacteriological and serological studies clearly demonstrated that the majority of patients with acute diarrhoeal disease admitted during this period of time were not suffering from V. cholerae infection; no known pathogen could be recovered from 86% of such patients. Biochemical studies indicated that, in contrast to the findings in cholera, factors other than saline depletion contributed to hypotension in many of the patients with non-vibrio diarrhoeal disease. Although the majority of the acute diarrhoeal patients responded well to the 2: 1 saline: lactate regimen which is consistently successful in treating adult cholera patients, six of the non-cholera patients required prolonged administration of vasopressor drugs as an adjunct to fluid and electrolyte repletion therapy.

Cholera↗