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Biomedical subjects

C K Conners

Publications and source records attributed to C K Conners.

At least 73 records · Page 4Linked to original sources
PubMed1980

Pemoline, methylphenidate, and placebo in children with minimal brain dysfunction.

An eight-week double-blind comparison between pemoline (Cylert), methylphenidate (Ritalin) hydrochloride, and placebo was carried out on 60 hyperactive children. Measurements of home, school, achievement, cognitive function, and global clinical status were made at baseline, midtreatment, end of treatment, and posttreatment. Both drugs produced improvement in all areas except the achievement measures. One major difference between drugs was the apparently longer action of pemoline, since its effects at home and school tended to persist when the drug was withdrawn, whereas the patients receiving methylphenidate tended to regress to their baseline levels.

Attention Deficit Disorder with Hyperactivity↗
PubMed1980

Visual-motor tracking by hyperkinetic children.

Two studies of a visual-motor tracking task purported to be an effective discriminator of subtypes of minimal brain dysfunction are presented. Performances of 16 psychiatric inpatients were compared with those of 14 hyperactive males and of 15 normal controls. A second study evaluated effects of practice and drug sensitivity on tracking. The task discriminated patients from normals but did not discriminate the groups of patients from each other. Interactions of practice, age, and diagnosis were found. Some degree of sensitivity of the task to stimulant medication was also obtained. Visual-motor tracking is a useful measure of stimulant drug action but does not measure a defect specific to hyperkinetic patients.

Age Factors↗
PubMed1979

Imipramine and EEG sleep in children with depressive symptoms.

Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a pilot study employing these techniques was undertaken in a population of hospitalized children. The EEG sleep of 12 children with significant depressive symptomatology was first examined after a two-week drug-free period and again approximately three weeks later when an optimum dose of imipramine had been maintained for at least 7 -- 10 days. Changes in sleep continuity, as reflected in increased wakefulness and a decreased sleep efficiency, as well as an increase in Stage 2 and a decrease in Stage 4 sleep, were observed throughout the entire sample. REM suppression was also noted, but tended to be most pronounced in those children who improved on imipramine.

Adolescent↗
PubMed1979

The acute effects of caffeine on evoked response, vigilance, and activity level in hyperkinetic children.

Seventeen hyperkinetic children who had previously responded to sympathomimetic amines were given three different dosages of caffeine in counterbalanced order (placebo, and low and high doses equivalent to one and three cups of coffee). One hour following ingestions they were tested, double-blind on measures of visual evoked response, alpha time, vigilance, and activity level. There was a significant effect on evoked response. The behavioral measures tended to be affected in a dose-related manner but not to a statistically significant degree. It is concluded that although centrally active, caffeine does not show the congruence between behavioral and central effects that other stimulants useful in behavioral management have shown.

Alpha Rhythm↗