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Biomedical subjects

C K Brown

Publications and source records attributed to C K Brown.

82 records · Page 5Linked to original sources
PubMed1979

Inhibition of mammary tumorigenesis in carcinogen-treated Lewis rats by suppression of prolactin secretion.

One hundred sixty-eight female Lewis rats were treated intragastrically with 10 mg 7,12-dimethylbenz[a]anthracene at 56 and 63 days of age. Pituitary prolactin secretion was suppressed in one-half of these rats by daily sc administrations of 2-bromoergocryptine mesylate (CB-154; 0.4 mg/100 g body wt) from 29 to 90 days of age (series 1) and from 90 to 140 days of age (series 2). Treatment with CB-154 was initiated prior to the onset of palpable mammary carcinomas. Control rats were given injections of saline. Inguinal mammary glands were excised from 10 control and 10 CB-154-treated rats at the cessation of saline and CB-154 treatments and examined for hyperplastic nodules (HN). The remaining rats were palpated weekly for mammary carcinomas (MC) and killed at 200 days of age. Mean number of HN per rat, mean number of MC per rat, and percent of rats with MC were, respectively: series 1--controls, 0.6, 1.5, and 68; CB-154 treatment, 0.5, 1.1, and 62; series 2--controls, 10.4, 2.0, and 94; CB-154 treatment, 5.1, 1.1, and 56. The number of HN and MC was only slightly reduced in rats when prolactin was suppressed during carcinogen treatment (series 1) but markedly reduced when prolactin was suppressed after carcinogen treatment (series 2). These results provide evidence that prolactin is involved in the early development of mammary dysplasias in the carcinogen-treated female Lewis rat.

9,10-Dimethyl-1,2-benzanthracene↗
PubMedDate not supplied

Animal procedure laboratory surveys: use of the animal laboratory to improve physician confidence and ability.

Animal laboratories have been used for many years to teach procedures. Our department has a weekly swine laboratory devoted to training residents, interns and students in resuscitative procedures. Physicians who participated in our swine procedure laboratory over the past three years were queried as to their prelaboratory and postlaboratory comfort levels with six different resuscitative procedures, and 57 (76%) physicians responded. Statistical analysis of the data showed significant improvement in comfort levels for all six procedures. Every responder felt the swine laboratory helped or will help them perform the procedures on humans. We also surveyed all U.S. emergency medicine residency program directors from established programs regarding the status of their animal procedure laboratories, and 67 of the 68 (98%) directors responded. Of these responders, 62% offer an animal procedure laboratory. Overall, 97% of the residency directors rated the laboratory successful, and 97% of the residents rated the laboratory successful. Therefore, we conclude that an ongoing emergency medicine animal procedure laboratory is a valuable tool for improving physician-in-training ability and confidence.

Animals↗
PubMedDate not supplied

Retained foreign body: a fingernail fragment?

A 19-year-old female presented four and one-half months after an occupational injury from a punch-type machine. Exploration revealed a large fragment of her fingernail embedded in the fingerpad. Foreign bodies are commonly encountered in the practice of emergency medicine and failure to localize and remove them can result in significant morbidity. We present a case of a fingernail as a foreign body. Foreign bodies may be difficult to detect despite sophisticated imaging techniques. Although not visualized often, a radiolucent foreign body may be inferred from boney changes. A thorough history regarding mechanism of injury and resultant wound exploration are required. When an adequate wound examination using digital tourniquet control and proper precautions is performed, the majority of foreign bodies will be detected.

Accidents, Occupational↗
PubMedDate not supplied

Descriptive epidemiology of local public health systems.

This article, presented at the Research and Measurement of Public Health Core Functions Science Symposium sponsored by the Centers for Disease Control and Prevention (CDC) in June 1994, provides selected data from the 1992-1993 National Profile of Local Health Departments. The National Association of County and City Health Officials (NACCHO), in cooperation with the CDC Public Health Practice Program Office, recently completed the 1992-1993 National Profile of Local Health Departments. This study describes public health at the local level and updates the first Profile study, conducted in 1989. The study population included 2,888 local health departments (LHDs) in the United States. Responses were received from 72% of LHDs. Comparisons are made with the 1990 Profile where available. This article provides a selected overview of the information contained in the 1992-1993 Profile and includes structure of LHDs, top agency executive, staffing, expenditures, and planning. The findings have important ramifications for community health planners and policy makers at all levels. With the ongoing potential for change in the U.S. health care system, reliable data establishing baselines and monitoring trends in public health at the local level are important. The information in this report, and the 1992-1993 National Profile of Local Health Departments, updates and expands the available knowledge of LHD structures and activities.

Humans↗