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Biomedical subjects

C K Anderson

Publications and source records attributed to C K Anderson.

At least 37 records · Page 2Linked to original sources
PubMed1979

Embryotoxic effects of pine needles and pine needle extracts.

A heat stable toxin present in needles of ponderosa pine was found to be soluble in methanol, ethanol, chloroform hexanes and 1-butanol. The embryotoxic effects of fresh green pine needles and a chloroform/methanol extract were determined by measuring embryo resorption in pregnant mice. Autoclaving the needles and extract for 1 hour prior to feeding enhanced the embryoresorptive effect by 28% and 32%, respectively. The results of this study revealed that the embryo resorptive dose (ERD50) of heat stable toxin for 1 mouse was 8.95 gms. for fresh green pine needles and 6.46 gms. for autoclaved green pine needles. In addition to embryocidal effects, feeding of the toxin resulted in significant weight loss in adult mice.

Animals↗
PubMed1978

Immunological studies of testicular tissue in oligozoospermic and azoospermic patients.

Testicular biopsies from 6 oligozoospermic and 12 azoospermic patients were examined histologically and immunohistologically. Evidence of maturation arrest and of Type II allergic reactions involving tubular basement membranes was found in all oligozoospermic patients. No evidence of an immune reaction was found in 9 azoospermic patients with maturation arrest. Unilateral or bilateral germ cell aplasia with evidence of mixed Type II and III or Type III and IV reactions was present in 2 oligozoospermic and 2 azoospermic patients. The findings have been interpreted to indicate that maturation arrest and germ cell aplasia may occasionally be linked in a chain of immunological events, initiated possibly by damage to tubular basement membranes. No correlation was demonstrable between the histological and immunohistological findings and indirect immunofluorescent tests for sperm antibodies. It is suggested that testicular biopsy is a potentially hazardous procedure in the investigation of infertility, and that prepubertal testicular tissues as well as sperm be used as antigens in the immunological investigation of infertility.

Antibodies↗
PubMed1978

Urethral tumours.

A series of 33 patients with urethral tumours has been studied to assess the risk of dissemination by endoscopic diathermy. This risk is less than that of cystourethrectomy. Urethral tumours should be treated like the vesical tumours they follow and so closely resemble: by endoscopic treatment while they remain small, sparse and superficial; by cystourethrectomy as soon as they become larger and more extensive. Recurrence of tumour in the urethral stump following cystectomy should always be treated by urethrectomy.

Aged↗
PubMed1978

Right ventricular heart failure of Montana cattle.

Congestive right ventricular heart failure of Montana cattle is characterized clinically by an accumulation of edematous fluid in the brisket region and ventral portions of the body but not of the legs. A well developed jugular pulse is first observed followed by a watery diarrhea and usually by the accumulation of excessive fluid in the pleural and peritoneal cavities. As the case develops over a period of two to three weeks, the ventral edema becomes more marked (Fig. 1) and straw-colored fluid may accumulate in the body cavities until the abdomen is distended and breathing labored. Death may occur as a result of respiratory failure due to the large volume of pleural fluid or from general debilitation as a result of the right ventricular failure. The incidence of this type of heart failure in Montana cattle is highest on moist mountain valleys. Eighty-one of 113 cases observed over a seven year period occurred in cattle that were maintained at altitudes of 1525 m or below. This paper describes the conditions under which the disease occurs in Montana and compares the hemograms of clinically ill and healthy cattle.

Animals↗
PubMed1977

Vascular and glomerular changes in the ageing kidney.

Glomerular size, shape and number were examined in 44 human kidneys obtained at necropsy. Intrarenal vascular appearances were assessed histologically and by post-mortem angiography. The mean cross-sectional area of glomeruli varied nearly three-fold and glomerular number varied more than three-fold when kidneys from different adult subjects were compared but kidneys from the same subject resembled one another in glomerular size and number. A significant negative correlation existed in the adult between glomerular number and dimensions. Glomerular numbers in the few immature kidneys studied were similar to those in adult kidneys but glomeruli were smaller. Glomerular numbers tended to decline as age and severity of age-related vascular changes increased but correlation was poor. The possibility remains that glomerular involution in the senescent kidney occurs independently of events in the vessels. In men, but not in women, totally hyalinised glomeruli were observed more frequently with increasing age but their presence did not appear to be related to the degree of vascular change. In the senescent kidney, glomerular lobulations tended to disappear. This, together with glomerular loss, must result in a reduction in the area available for filtration. Assessments of total glomerular surface area should take account of glomerular shape and dimensions as well as numbers.

Adult↗
PubMed1977

Pine needle toxicity in pregnant mice.

Eight groups of pregnant mice were fed various preparations of ground pine needles or aqueous extracts thereof. An additional group was fed only Purina mouse cubes. Ground pine needles were more toxic to both adult mice and embryos than were the various water extracts. Reproductive failure occurred early in the gestational period. A water soluble and heat labile toxin suggestive of a mycotoxin was demonstrated in water extracts. Pine needle fiber contained a heat stable toxin which was insoluble in water. Evidence suggested the possible presence of a third toxin lethal for adult mice. Results suggested that the heat stable toxin is the one of greatest importance as a source of reproductive failure in mice. Toxins produced by fungi were considered to be of secondary importance.

Animals↗
PubMed1976

Estimation of glomerular size and number from radiographs of the kidney.

In 32 adult human kidneys obtained at necropsy, renal demensions, measured from radiographs, were correlated with the number and cross-sectional area of glomeruli, determined by point-counting and computerized image analysis. Cortical area, measured from post-mortem angiograms, was poorly correlated with glomerular area and was not significantly correlated with glomerular number per kidney. The area of the whole kidney was poorly correlated with the number of glomeruli per kidney and was not significantly correlated with glomerular area. However renal dimensions, particularly total renal area, were highly significantly correlated with the product of glomerular area and number. This may allow glomerular numbers to be estimated in life but will not assess loss of glon the ageing kidney, the number of glomeruli per unit volume increased.

Adult↗
PubMed1975

Sarcoidosis of the penis treated by radiotherapy.

A case of sarcoidosis of the penis is reported which initially caused ulceration around the external urethral meatus. After an immediate response to steroid therapy, the disease recurred locally in spite of continuing therapy and involved other parts of the penis. Partial amputation of the penis was performed but further ulceration occurred at the cut ends of the corpora cavernosa in the penile stump. This ulceration healed after radiotherapy.

Biopsy↗
PubMed1975

Calf ligated intestinal segment test to detect enterotoxigenic Escherichia coli.

The ligated intestinal segment test in the young calf was utilized to establish the enterotoxigenicity of approximately 600 Escherichia coli isolates obtained from fecal specimens intestinal contents of calves with diarrheal disease. One hundred and fifty isolates were routinely tested in a single calf. There was little problem with false-positive reactions. False-negative reactions normally occurred only if the isolate was tested in the posterior 3 m of the small intestine. The ligated small intestine of the calf was distended by E. coli isolates of bovine, porcine, and human origin. Use of the calf ligated intestinal segment test is recommended to determine the enterotoxigenicity of E. coli isolates of bovine origin.

Animals↗