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Biomedical subjects

C Jorgensen

Publications and source records attributed to C Jorgensen.

At least 91 records · Page 5Linked to original sources
PubMed1989

H-Y antigenicity of human fibroblasts.

Injection of cultured fibroblasts from male C57BL/6 mice resulted in accelerated rejection of subsequent male C57BL/6 skin grafts, whereas the injection of cultured fibroblasts from human males failed to have this effect.

Animals↗
PubMed1985

Limitations of a histologic assay for syn-, allo-, and xenogeneic H-Y antigen.

In view of the potential significance of the H-Y antigen in the etiology of cases of sexual ambiguity we have attempted to develop a clinically useful test for the presence of H-Y on the cells of such patients. The attempts were directed at the detection of accelerated or decelerated rejection of syngeneic skin grafts on H-Y-incompatible mice previously exposed to H-Y positive syngeneic, allogeneic, or xenogeneic cells. Using a simple and rapid histologic assay after exposure to syn- or allogeneic cells, acceleration (sensitization) as well as deceleration (tolerance) was readily demonstrable. However, the assay was not helpful with the use of xenogeneic (rabbit, human) cells.

Animals↗
PubMed1980

In vivo radiographic appearance of the St. Jude valve prosthesis.

The St. Jude valve prosthesis has radiopaque leaflets which can be seen by cinefluoroscopy to determine their in vivo movement. Laboratory and clinical experience with visualization of various components of the prosthesis is described.

Evaluation Studies as Topic↗
PubMed1979

Insulin and glucose responses in rats fed sucrose or starch.

Rats fed 54% sucrose for 11 to 13 weeks ad libitum or 5 weeks ad libitum followed by 6 to 8 weeks of meal feeding had significantly higher serum insulin, glucose, and triglyceride levels than rats fed comparable amounts of starch after 12 to 14 hr without food. The serum insulin response measured before, 1/2, and 4 hr after a meal showed insulin levels of sucrose-fed rats to be higher than comparable levels of rats fed starch at all three times. An intraperitoneal glucose tolerance test measuring serum glucose before, 1/2, 2, and 2 hr after a glucose injection revealed glucose levels of rats fed sucrose to be higher than levels of rats fed starch. When insulin was added to the injection medium, serum glucose of rats fed sucrose remained higher than comparable levels of rats fed starch indicating insulin insensitivity. Meal feeding generally resulted in higher insulin and triglyceride levels than in rats fed ad libitum but had little effect on glucose levels. These results are clear evidence that sucrose feeding has undesirable effects on glucose tolerance.

Adipose Tissue↗
PubMedDate not supplied

The health effects of worksite HIV/AIDS interventions: a review of the research literature.

PURPOSE: To examine the individual and organizational health effects of HIV/AIDS interventions conducted at the worksite. SEARCH METHODS: This review is part of a series of reviews that used search methods described in an introductory article. To supplement these methods, HIV/AIDS-specific periodicals were searched to include journals that might not be incorporated in the computerized databases. Twelve of the 20 articles identified through the Centers for Disease Control and Prevention and our own subsequent searches met the criteria and were included in this review. FINDINGS: Ten of the 12 studies reviewed reported positive effects of employee education programs on knowledge or attitudes. Nine of the studies involved health care workers or employees with potential occupational exposure to HIV, and nine lacked a comparison or control group. None of the studies however, examined the effects of policies, manager training, or family education on the organization or person. CONCLUSIONS: Methodologic weaknesses in many of the studies reviewed, coupled with the small number of studies, led us to conclude that the research literature on worksite HIV/AIDS interventions is weak. Impact is, however, plausible. Future research should be directed toward developing valid measures of key variables, controlling for confounding factors, and ultimately examining the impact of organizational factors.

HIV Infections↗