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Biomedical subjects

C Johansen

Publications and source records attributed to C Johansen.

At least 91 records · Page 5Linked to original sources

[Patients coping with cancer. A review].

The expression coping is defined. Theoretically, coping is described as either unconscious ego defences or as an expression of concious process. The literature which employs the expression coping in connection with cancer is described. Several methodological problems exist. The initial criteria, the nature of the disease and the time of diagnosis and various types of treatment are some of the factors which inhibit the quality of the investigation. In addition, no discussion is available about the extent to which scientific methods can be employed in assessing the process of coping. Only few investigations are concerned with intervention but the results suggest that it is possible to improve cancer patients' ability to cope with the problems which develop on account of the diagnosis and subsequent treatment. Further investigation of the expression, the methods of investigation and intervention are necessary to elucidate the employability in clinical practice.

Adaptation, Psychological↗

Fertility and pregnancy in women with familial adenomatous polyposis.

A questionnaire study was carried out among 58 Danish women with familial adenomatous polyposis concerning fertility, pregnancies, abortions and deliveries. Further data were obtained from obstetric records and general practitioners. The fertility and the course of the pregnancy of women with polyposis, frequency of miscarriages, legal abortions, mature and premature infants corresponds to the frequency among the obstetric population in Denmark. Of the 73 infants, eight (11%) were delivered by caesarean section. Of the 16 women who gave birth after an operation for familial adenomatous polyposis, 5 (31%) had a caesarean section. Of the seven infants who died, two had lethal congenital malformations and three infants were very premature.

Abortion, Legal↗

[Pregnancy in women with congenital heart disease].

During the past decades, the incidence of pregnant women with heart disease in Denmark has decreased from 0.9% to 0.3%. Heart disease in connection with pregnancy still remains the commonest non-obstetric cause of death. Previously, rheumatic valvular heart disease constituted the majority of all forms of heart disease in pregnant women. At present, congenital heart disease constitutes at least 80% of the maternal heart disease. Progress in heart surgery has had the result that increasingly more complicated forms of cardiac deformities can be corrected so that more survive to adult life. The range of cardiac deformities has therefore increased in recent accounts concerning pregnant women with heart disease. Ventricular septum defect, atrial septum defect and persistent ductus arteriosus still constitute approximately 50% of the forms of heart disease in pregnant women. In Denmark, the incidence of congenital heart disease is approximately 0.6% but between 2.5% and 4.2% of infants of women with congenital heart disease also have heart disease. In counselling about the risks in pregnancy, the NYHA scale provides a good guideline. Alle conditions with pulmonary hypertension are contraindications for pregnancy. The greatest risk for death occurs early in the puerperium. Guidelines for control and treatment of pregnant women with heart disease are presented. It is concluded, that pregnant women with heart disease should be assessed and be followed up in centres with the necessary cardiac, obstetric and anaesthesiologic expertise.

Denmark↗

Tricuspid atresia and pregnancy.

Four cases of pregnancies in two women with tricuspid atresia (TA) are described. A review of the literature on this subject revealed 24 reported cases of which only 11 were reported in detail. Eight pregnancies resulted in deliveries (including our 3 cases). TA is still uncommon in adult patients, but due to successful palliative surgery in childhood more patients now reach the age of fertility. Guidelines about the management of these patients are discussed.

Adult↗

Maternal heart disease. A survey of a decade in a Danish university hospital.

Among 87 pregnancies complicated by heart disease, delivered during the decade 1977-86, 70 (81%) had a congenital heart malformation, 7 (8%) an acquired heart disease and 10 (11%) arrhythmias or conduction disturbances. The incidence was 0.3%. The corresponding data from a report from Rigshospitalet during the 1950s were: 42%, 49%, and 9%, respectively, and an incidence of 0.9%. Ventricular septal defect (VSD) and atrial septal defect (ASD) were the most frequent malformations. The women were classified according to the NYHA before, during and after the pregnancy. All women except 4 re-entered their original functional class. In 51 cases, ECG showed completely normal sinus rhythm, while in 36, various degrees of arrhythmia or conduction disturbance were found as well as left or right ventricular hypertrophy and/or strains. Nine infants had congenital defects, 4 of which were a heart malformation (4.6%). One infant died. Gestational duration, weight and perinatal mortality did not differ significantly from that of the general population. Two women died, one of primary pulmonary hypertension and one with a rupture of the thoracic aorta. Rheumatic heart disease is no longer a significant factor in relation to pregnancy in Denmark, but congenital heart disease is still of great importance, because more survive and reach the age of fertility. Today most women can be brought safely through pregnancy, but obstetric, cardiologic and anesthesiologic expertise is still mandatory for a successful course and outcome of pregnancies complicated by heart disease.

Adult↗

Eisenmenger's syndrome and pregnancy.

Two cases of successfully managed Eisenmenger's syndrome during pregnancy are reported. A women suffering from Eisenmenger's syndrome who becomes pregnant should be advised to have her pregnancy terminated. On the basis of the available literature and our own experiences we suggest the following plan, if a woman, despite medical advice, chooses to continue her pregnancy: admission to hospital at approximately 25 weeks of gestation; bed rest during the remaining period of pregnancy; oxygen face-mask during episodes of dyspnoea; determination of serial blood gases to detect changes in the shunt flow. At the onset of labour, arterial and epidural catheters should be inserted, a fall in blood pressure should immediately be counteracted by the administration of norepinephrine and loss of blood by transfusion. The patient should remain in hospital for 7-14 days after delivery.

Adult↗

Potassium Fluxes during Potassium Absorption by Intact Barley Plants of Increasing Potassium Content.

The presence of previously absorbed K in plants caused a marked reduction in the short term influx of (86)Rb-labeled K into roots of barley seedlings. The influx values agreed with net K absorption rates into intact plants, thus suggesting that K efflux was negligible in comparison with influx.Earlier interpretations of a large K efflux component from excised roots approaching equilibrium K concentrations are considered to be due to an underestimation of net K absorption rates resulting from xylem exudation as the K status of the roots increased.

Journal Article↗

Interactions between potassium and calcium in their absorption by intact barley plants. I. Effects of potassium on calcium absorption.

Increasing concentrations of K (20, 200, 2000 mum) in the nutrient solution depressed Ca content and concentration in barley plants growing in nutrient solutions of low Ca concentrations (250 and 2500 mum). Increasing K from 20 to 200 mum depressed Ca absorption more than increasing K from 200 to 2000 mum K.The strong depression of Ca absorption by low concentrations of K must involve a different process from that studied by other workers at high concentrations of K. Since the depression in net absorption of Ca was as great at 250 as at 2500 mum Ca the results fail to support previous suggestions that a specific mechanism for Ca absorption operates at low Ca concentrations. It is suggested that, at the low concentrations of K and Ca likely to be found at the root surface in many soil solutions, the above mentioned effect of K in inhibiting Ca absorption may be important in the Ca nutrition of plants.

Journal Article↗

Interaction Between Potassium and Calcium in Their Absorption by Intact Barley Plants. II. Effects of Calcium and Potassium Concentration on Potassium Absorption.

Rates of K absorption by young barley plants grown for 20 days in flowing nutrient solutions have been studied at 3 solution K concentrations (20, 200, and 2000 mum) and at 2 Ca concentrations (250 and 2500 mum). Increasing solution K increased plant K content, concentration, and rate of absorption: solution Ca concentrations had no effect at any K level.Rates of K absorption were only one-half to one-fifth of those reported for excised barley roots at similar K concentrations in solution. If the reported rates of K absorption by the high-affinity mechanism in excised barley roots were maintained in growing plants they would have given, within 3 days, the equilibrium concentrations of K in plants of the present experiment. Thereafter the rates of K absorption by the high-affinity mechanism would have been more than adequate to maintain plant K and would need to have been compensated by K efflux.It is suggested that, for all concentrations of K in solution, the high-affinity mechanism dominates the absorption of K by barley plants grown for more than a few days.

Journal Article↗

Antibodies to Japanese encephalitis virus in human sera collected from Irian Jaya. Follow-up of a previously reported case of Japanese encephalitis in that region.

Japanese encephalitis virus (JEV) and other arboviruses are demonstrating an emergence in the southern part of New Guinea Island. JE was previously unknown in this part of the world until 1995 when it was found in the Torres Strait, northern Australia. In this study 96 sera collected from residents of the Timika region of Irian Jaya were tested for antibodies to JEV and related arboviruses by epitope-specific blocking ELISA. Of the 9 sera deemed to be positive for JEV antibodies by ELISA, 5 were collected from persons indigenous to Timika, and who had not travelled to regions where JE is known to be active. This indicates that these individuals were infected with JEV in the Timika area and supports a recent report of a clinical case of JE in this region. Non-immune expatriates visiting or working in the Lowland areas of Irian Jaya and/or Papua New Guinea should consider immunization against JE. Precautions should always be taken to avoid being bitten by any mosquito both in the daytime and at night.

Antibodies, Viral↗