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Biomedical subjects

C Jesdinsky-Buscher

Publications and source records attributed to C Jesdinsky-Buscher.

9 recordsLinked to original sources
PubMed1977

Alteration of primary hemostasis in hemophiliacs after treatment with lyophilized antihemophilic globulin.

Seven patients with classic hemophilia A had alteration of primary hemostasis after treatment with lyophilized antihemophilic globulin (LAHG). The following test results, which were normal before treatment, became abnormal after treatment: bleeding time, bleeding intensity, and platelet adhesiveness. In two patients, the fibrin-fibrinogen-degradation products increased to more than 40 microgram/ml. In three patients, the bleeding symptoms became worse with LAHG therapy although no inhibitor against Factor VIII was demonstrated. In one of these patients, the bleedings symptoms disappeared when the use of LAHG was discontinued and prednisone was given; at the same time, the altered primary hemostasis returned to normal. In the remaining two patients, prednisone did not have any effect. In these two patients, however, the bleeding stopped, and the bleeding time became normal immediately after freshly prepared blood-group compatible cryoprecipitate was given.

Adolescent↗
PubMed1976

[Changes in hemostasis during epilespy treatment using dipropyl acetate. Extended study].

The influence of Dipropyl-Acetate (DPA, Ergenyl) on hemostasis parameters was examined in 12 patients. In 8 cases there was a prolongation of bleeding time, in 2 cases thrombocytopenia, in 6 out of 10 cases the platelet adhesiveness was pathologically reduced. We therefore recommend hemostasis-examinations--with emphasis on the thrombocytic system--in patients taking DPA.

Adolescent↗
PubMed1976

Detection of carriers of hemophilia by hemorrhagometry.

Hemorrhagometry measures bleeding time, bleeding intensity and blood loss from a small standardized skin wound. In patients with hemophilia these values are within the normal range when hemorrhagometry is performed at room temperature (24 degrees C). However, when the wound is cooled to 17 degrees C (cold tolerance test), bleeding time is abnormally long in hemophiliacs. Therefore we applied this test to carriers of hemophilia. The cold tolerance test was performed in 16 proven and 6 probable carriers (criteria according to Nilsson). 14 proven and 4 probable carriers showed abnormal bleeding times of 15 min and more. When hemorrhagometry was performed at room temperature, the carriers could not be distinguished from normal control persons. Of 15 sisters and aunts of hemophiliacs without male offspring (potential carriers) 9 had abnormal cold tolerance test findings, in fair agreement with the probability of 0.5 to be expected theoretically. Thus the hemorrhagometry cold tolerance test seems to be helpful in detecting carriers of hemophilia.

Blood Coagulation Tests↗
PubMed1975

[Bleeding in haemophilia during massive treatment with anti-haemophilic globulin (author's transl)].

After a traffic accident, causing intracranial haemorrhage in a 15-year-old boy with moderately severe haemophilia A, severe bleeding sequelae could not be prevented despite satisfactory substitution with lyophilized antihaemophilic globulin. The bleeding was probably due to a platelet abnormality and not due to an inhibitor. The bleedings were brought under control by freshly prepared cryoprecipitate of the patient's own blood group.

Accidents, Traffic↗
PubMed1975

[A new in vivo method for the detection of carriers of haemophilia (author's transl)].

We examined 14 carriers of haemophilia A with the "Haemorrhagometer". The cold tolerance test (at 17 degrees C) revealed that 9 out of 10 proven and 3 out of 4 probable carriers had a pathologically prolonged bleeding time. Accordingly blood loss was pathologically elevated in 9 out of 10 proven and 2 out of 4 probable carriers. At room temperature the difference between normal control persons and carriers of haemophilia A was not as pronounced. 5 of 8 proven and 3 of 4 probable carriers showed pathologically elevated bleeding intensity, only 1 of 8 proven and none of 4 probable carriers showed abnormally prolonged bleeding time. Haemorrhagometry at 17 degrees C (cold tolerance test) may be helpful to ascertain whether or not a woman is a carrier of haemophilia A.

Blood Coagulation Tests↗
PubMed1975

[Normal data for hemorrhagometry (author's transl)].

Normal data for hemorrhagometry were established in 43 control persons, aged between 4 and 14 years. At room temperature the mean value for bleeding time was 4.61 min. (upper limit of normal 7.7 min.), the mean hemoglobin loss, which corresponds to the blood loss, was 4.34 mg (upper limit 14.74 mg), the mean value for maximal bleeding intensity was 21.4 mug hemoglobin/sec. (upper limit 48.8). When hemorrhagometry is performed at 17 degrees C (cold tolerance test) bleeding time is prolonged (mean 9.02 min., upper limit 14.3 min.), bleeding intensity increases (mean 32.4 mug Hb/sec., upper limit 81.3 mug/sec.), and hemoglobin loss rises (mean 11.07 mg, upper limit 31.36 mg). Bleeding time determinations according to IVY yield shorter values (mean 2.99 min., upper limit 4.5 min.) than those obtained by hemorrhagometry at room temperature. There was no positive correlation between hemorrhagometry parameters and age, sex, and number of thrombocytes, as long as thrombocyte counts above 100.000/mm3.

Adolescent↗