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Biomedical subjects

C Janbon

Publications and source records attributed to C Janbon.

82 records · Page 5Linked to original sources
PubMedDate not supplied

A prospective epidemiological study on the occurrence of antiphospholipid antibody: the Montpellier Antiphospholipid (MAP) Study.

The objective of this study was to determine the prevalence and clinical significance of elevated antiphospholipid antibodies (APA) in a large series of patients admitted to a department of Internal Medicine. At the end of entry phase, 1014 patients were tested (488 males-526 females, mean age: 66.7 years, range 18-97). Seventy-two (7.1%) patients were found APA positive at least once: 44 males and 28 females, mean age 69 years, range 23 to 94. Twenty fulfilled the criteria of Primary Antiphospholipid Antibody Syndrome: 10 patients were referred for deep vein thrombosis, 3 had history of deep vein thrombosis, 1 had both arterial thrombosis and a history of venous thrombosis; 2 had thrombocytopenia; 3 had stroke, 1 had a history of a stroke. One patient had SLE according to ARA classification. The most frequent associated disease was cancer: 14 patients, 9 had evolutive malignant disease, 5 were in clinical remission of neoplasia. Other clinical conditions included chronic and/or acute alcoholic intoxication (n = 8), severe atherosclerosis (n = 4), leg ulcer (n = 4). Insufficient data are available about the evolution, but 7 patients died in the year following diagnosis. Eight patients had fluctuations in APA detection: 2 initially APA positive became negative, 5 initially negative became positive and 1 patient was alternatively positive, negative and positive without steroid treatment. Thus, as expected, APA occur in a variety of clinical disorders. The association with cancer or alcoholic intoxication deserves further investigations.

Adolescent↗
PubMedDate not supplied

Social and economical effectiveness of non-invasive vascular examinations in the clinical management of thrombo-embolic disease.

In a retrospective study about the seven past years in our Hospital Center, we found that the number of X-ray venographies increased strongly from year to year until non-invasive examinations (Doppler and plethysmography and Real-time B-mode sonography) were widely used with a high sensitivity and specificity level. A new diagnostic algorhythm was then introduced in the clinical practice, X-ray venography being required mainly when an invasive treatment (thrombectomy, thrombolysis, vena cava interruption...) was planed, but not for the positive diagnosis. Thereafter, the number of X-ray venographies decreased. In that way, the cost of the diagnosis was significantly reduced as were risks and discomfort for the patient.

Cost Control↗
PubMedDate not supplied

[Chronic lymphocytic leukaemia with cutaneous lesions and deafness following periarteritis nodosa (author's transl)].

A case is reported of a 49 years-old man who presented with cutaneous and muscular manifestations revealing periarteritis nodosa. Two years after detection of this disease occured a preleukemic condition and four years later a chronic lymphocytic leukaemia is discovered. In clinical course appeared a tuberous infiltration of the face and a sudden bilateral deafness. Regression of these two abnormalities is obtained after administration of prednisolone. The patient died of generalized infectious process postoperatively. From these clinical and pathological findings relations between periarteritis and CLL, occurence of deafness and cutaneous lesions are discussed. The relationship between the development of CLL and the immunosuppressive treatment is considered.

Deafness↗
PubMedDate not supplied

[Prolymphocytic leukemia of T-cell type. Clinical, cytological, cytochemical and immunological studies (author's transl)].

Prolymphocytic leukaemia (PL) is a rare variant of lympho-proliferative disorder, defined by Galton [21], which differs clearly from CLL by clinical, haematological and immunological features. Nevertheless like CLL, PL appears to represent predominantly a B cells monoclonal proliferation and cases of T-PL are rare. We report about another case of PL which was found to have T-lymphocyte characteristics and some clinical and immunological particularities.

Aged↗
PubMedDate not supplied

[Venous Doppler color echography: importance and inconveniences].

Color Doppler is a technique which performs a real-time opacification of the vascular system with blue indicating reverse flow and red indicating forward flow (directional color coding). In venous pathology, the use of color Doppler improves significantly the anatomical evaluation of the inferior vena cava, the iliac vein, the deep femoral vein, and the sural system. Color Doppler facilitates the study of deep venous thrombosis (providing useful information to differentiate ancient from most recent thrombus) and also the study of post-thrombotic conditions (assessment of reverse flow, repermeation phenomena). Finally, color Doppler produces a better insight for the study of varicose veins, especially with regard to mapping, identification of communicante veins, and study of the external saphenous vein.

Blood Flow Velocity↗