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Biomedical subjects

C Jakobeit

Publications and source records attributed to C Jakobeit.

29 records · Page 2Linked to original sources
PubMed1990

Gallbladder stone fragments in feces after biliary extracorporeal shock-wave lithotripsy.

All stools passed on the first 3 days after extracorporeal shock-wave lithotripsy of gallbladder stones in 21 patients were collected and examined for the presence of stone fragments. A total of 555 fragments varying in number per patient (4-69) and in size (maximum diameters from 0.5-8.0 mm) were recovered by sieving aqueous suspensions of the feces. All 482 fragments less than or equal to 3.0 mm left the biliary tract without any clinical symptoms, as did the three largest fragments with maximum diameters of 7.0-8.0 mm and almost all of the 70 fragments measuring 3.5-5.0 mm. During the observation period, four episodes of biliary complaints were recorded in three patients in whom fragments with maximum diameters of 3.5-5.0 mm were found. The only chemical abnormality was a temporary elevation of lipase activity to twice the normal range in 1 case. All fragments were identified as gallbladder stones by infrared spectroscopy on the basis of their (varyingly high) cholesterol content. By macroscopic criteria, most of the fragments were from mixed stones; therefore, provided there is a functioning gallbladder and sufficiently fine fragmentation, successful extracorporeal shock-wave lithotripsy does not seem to be limited to pure cholesterol stones.

Abdominal Pain↗
PubMed1989

[Extracorporeal shockwave lithotripsy of bile duct stones].

Extracorporeal lithotripsy (EL) was undertaken in 50 patients (mean age 73.7 years; range 29-90 years) with extrahepatic and, in five, with intrahepatic gallstones, the usual endoscopic methods having been unsuccessful in removing the stones. Occasionally stone fragments were passed spontaneously, but in most they had to be removed endoscopically, in 48 (96%) with extrahepatic and in three (60%) with intrahepatic stones. Biliary tract or gallbladder infections occurred after the lithotripsy and associated local litholysis in seven of the 48 with extrahepatic (14%) and three of the five (60%) with intrahepatic stones. There was one hospital death. The results indicate that EL has definite advantages over surgical treatment in these patients, who are usually elderly and in whom surgical intervention is more risky.

Adult↗
PubMed1987

[Biliary shock-wave lithotripsy. Fragmentation and lysis--a new procedure].

Between September 1986 and April 1987, extracorporeal shock-wave lithotripsy, supplemented by oral chemolitholysis, was undertaken on 157 patients with symptoms of gallstones. Partial or complete stone fragmentation was achieved in 148 (94.3%). Freedom from stones was maintained under continuous chemolysis treatment for an average observation period of 8.5 weeks in 31 (19.7%). Considerable fragment reduction was obtained in 97 (61.8%), of whom 26 (16.6%) were demonstrated to have only minimal stone residues. Insufficient fragmentation and (or) no response to litholysis occurred in 29 (18.5%). These preliminary results suggest that, if there are moderately sized (less than 25 mm) and only a few (1-3) noncalcified cholesterol stones, these two methods in combination promise to be an effective alternative to cholecystectomy.

Adult↗
PubMed1986

[Ultrasound-controlled puncture procedures: free-hand puncture versus transducer biopsy puncture. 5 years' experience].

To compare the accuracy of both ultrasound-guided puncture methods 417 patients were examined over a period of 5 years (retrospectively). Our results show no significant difference in accuracy between free-hand puncture and biopsy transducer puncture. It may be that puncture of very small (less than 2 cm) und very deep (greater than 8 cm) targets by biopsy transducer is a little more advantageous. In our opinion free-hand puncture is time-saving. Free-hand puncture allows a better visibility of the biopsy-needle artefact and is better practicable in case of anomalies of body structure. We did not observe complications worth mentioning with any of these two methods. We prefer free-hand puncture.

Biopsy, Needle↗
PubMed1980

Effects of selective ultraviolet phototherapy (SUP) and local PUVA treatment on DNA synthesis in guinea pig skin.

The treatment with UV-light with wavelengths between 292.5--335 nm (known as selective UV-phototherapy, or SUP) and 320--390 nm (plus local treatment with 8-methoxypsoralen, known as PUVAex) gave rise to a biphasic reaction of epidermal cell proliferation in guinea pig skin. A decrease of proliferative activity was followed by a synchronized stimulation of DNA synthesizing cells after 2--4 h. These quantitative displacements were accompanied by qualitative changes in the proliferative behaviour of epidermal cells in the S-compartment.

Animals↗
PubMedDate not supplied

Ultrasound-guided extracorporeal shock wave lithotripsy of pancreatic ductal stones: six years' experience.

Extracorporeal shock wave lithotripsy (ESWL) and endoscopic sphincterotomy (EST) was performed in 35 patients suffering from pancreatic duct stones. Calculi disintegration and resolution of obstruction were achieved in all cases. Completely stone-free ducts were achieved in 16 patients (46%) while some peripheral asymptomatic stone material remained in 19 (54%). Dilation of the main pancreatic duct was reduced in 29 patients (83%). Twelve patients (34%) became completely asymptomatic and 17 (49%) reported a marked reduction of pain. Pancreatogenic steatorrhea ceased and 18 patients (51%) gained weight. Pathological glucose tolerance returned to normal in one patient. No major complications were observed. The combination of ESWL and EST is a successful, nonoperative, new treatment in pancreatic stone disease.

Adolescent↗