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C Jaffiol

Publications and source records attributed to C Jaffiol.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

[Multidimensional discriminative analysis for predicting the outcome of Graves' disease (author's transl)].

Attempts to identify at an early stage of Graves' disease patients who will respond favorably to the various treatments available have been largely unsuccessful. However, all such studies have been based on the measurement of a single discriminant at a time, and in an attempt to improve predictive accuracy we have made use of multidimensional techniques which analyse several factors simultaneously. The overall accuracy in predicting the outcome in drug-treated patients, before treatment was started, was 79% ; in RAI treated patients 88 %. There remains a residuum of patients whose fluctuations in disease activity are such as to defy all prediction of outcome.

Antithyroid Agents↗
PubMedDate not supplied

[Contraception in diabetic women].

The choice of a contraceptive method for diabetic women must take into account metabolic and vascular risks. Combined oestrogen-progestogen contraception is not contra-indicated in insulin-dependent diabetes but requires close supervision. Progestogens alone for nulliparous women and mechanical devices for multiparous women appear to be preferable. Oral contraceptives have a more limited use in insulin-independent overt or chemical diabetes. In such patients combined oestrogen-progestogen contraception is absolutely contra-indicated and progestogens should be given under strict metabolic monitoring. The potential risks incurred by these women already liable to vascular and metabolic complications make male contraception even more desirable.

Adult↗
PubMedDate not supplied

[The 20 min. iodine uptake in Graves' disease. 1. Technique and reliability (author's transl)].

The 20 minute intravenous radioiodine uptake technique is described in detail and results compared with those from the classical 2 1/2 hour oral uptake in 93 Graves' disease patients. Two methods used in correcting for extrathyroidal radioactivity in the early uptake are similarly compared. The 20 minute uptake was normal (locally less than 8% dose) in only 6,5% of the patients while the 2 1/2 hour uptake was normal (locally less than 35% dose) in 18,5%; in six patients the uptake at 20 min. was higher than at 2 1/2 h, observations indicating the superior sensitivity and diagnostic value of the early uptake. The suppression test performed at 20 minutes was, furthermore, pathological in 97,8% of patients. The comparison of methods to correct for extrathyroidal radioactivity in the 20-minute test showed excellent agreement between thigh count subtraction and application of a formula based on the thyroid uptake at 2 minutes. The former technique, however, was considered to be simpler. We conclude that the 20 minute intravenous iodine uptake technique is not only simpler to perform than the classical oral method, but is also diagnostically more accurate. A high quality scan was obtained 30-60 minutes after the injection of radioiodine in most of these patients.

Administration, Oral↗
PubMedDate not supplied

[The 20-minute iodine uptake in Graves' disease. 2. Natural course during medical treatment (author's transl)].

The early (20 min) radioiodine uptake has been used to monitor the fluctuations in disease activity among 35 Graves' disease patients treated for 18 months with carbimazole and T3. A wide variety of behaviour was observed. Although as a group the uptake tended to fall progressively with time, in some it fell only to rise again and in others it fluctuated erratically. The initial fall in uptake in a substantial minority of patients was sufficient to suggest that carbimazole may exert a fundamental and beneficial influence of the immunological disturbance in Graves' disease.

Carbimazole↗