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Biomedical subjects

C Jacquot

Publications and source records attributed to C Jacquot.

At least 199 records · Page 11Linked to original sources
PubMed1976

[Effect of normobaric and hypobaric hypoxia on norepinephrine turnover in the rat heart (author's transl)].

1. After administration of 3H norepinephrine (NE), the turnover rates of NE were determined by the decrease in radioactivity. 2. Rats were housed by groups in chambers and either maintained as controls or exposed to a hypoxic environment (PIO2 = 90 torr). The turnover rates of NE were not altered by normobaric hypoxia (fig. 1, table I). 3. Hypobaric hypoxia (barometric pressure was reduced to 500 mm Hg and PIO2 was 105 torr) increased the turnover rates of NE (fig. 2, table II). 4. The role of the sympathetic nervous system during exposure to hypoxia in Rats is discussed with regard to functional adaptation.

Adaptation, Physiological↗
PubMed1976

[Pharmacokinetics of DL-norephedrine 14C in the rat].

After i.v. administration of DL-norephedrine 14C to the rat (535 mug/kg), approximately 75% of the radioactivity was eliminated during the first 18 hr in the urine. Beside the unchanged drug (71.5% of the total urinary radioactivity), the main metabolite was alpha-methyloctopamine (18%), a parahydroxylated derivative of which 68% were excreted as glucuronide conjugates. Kinetic studies of DL-norephedrine in different organs showed that the affinity of tissues for the amine did not change with time. Captation was important and rapid in lungs, adrenals, spleen and heart. The brain was marked by a slow increase of drug level during the first 2 hr. However, the terminal semi-exponential kinetic slopes of DL-norephedrine concentration showed that the elimination processes of the drug were the same in each tissue. The affinity of tissues for alpha-methyloctopamine was shown to be much more specific; its uptake was higher in organs which are rich in adrenergic nerve endings (heart, adrenals and spleen). These results confirm the role of this hydroxylated amine as a false neurotransmitter. A whole body autoradiography in the mouse showed an important uptake of DL-norephedrine 14C in salivary glands and periocular structures.

Animals↗
PubMed1975

[Comparative subcellular localization of para-hydroxylated derivatives of ephedrine and amphetamine in rat brain].

Localisation of noradrenaline, hydroxyamphetamine, hydroxynorephedrine and hydroxyephedrine was studied in adrenergic granules of rat's brain in normal animals and in animals injected with hydroxy-6 dopamine. In normal animals the synaptosomes fixed noradrenaline, first and then, in decreasing order, hydroxynorephedrine, hydroxyephedrine and hydroxyamphetamine. Hydroxy-6 dopamine injection resulted in a decrease of fixation by synaptosomes, thus confirming the role of central false-transmitters of hydroxylated derivatives of amphetamine and ephedrine.

Amphetamines↗
PubMed1975

[Pulmonary water and thoracic impedance. Evaluation of a measurement technic].

We measured transthoracic electrical impedance in 17 anesthetized and mechanically ventilated dogs with a four-electrode system. A current (5 KHZ, 50 mu A) is injected and detected at axillary levels. Transthoracic impedance was 67 +/- 14 ohms (S.D.) with insignificant shifts in control animals. Pulmonary edemas were induced by saline and dextrose overloads with large but opposite variations in impedance. Fifty to hundred per cent increases in total lung water content (determined at autopsy) were induced by intravenous injection of alloxan or instillation of endotracheal saline. Significant but small decreases in impedance followed. Validity of experimental pulmonary edemas with or without blood resistivity and pulmonary blood volume changes is discussed.

Animals↗