[Bacterial examination of ice cream. Results and analysis].
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Belgium↗
Biomedical subjects
C Jacques
Publications and source records attributed to C Jacques.
[Disorders of haemostasis in patients undergoing maintenance haemodialysis, with special reference to recurrent arteriovenous fistula thrombosis. Effects of dipyridamole (author's transl)].
Platelet functions and blood coagulation have been regularly investigated in 31 patients undergoing maintenance haemodialysis for 5 months to 6 years. Fifteen of them suffered from at least two arteriovenous fistula thrombosis during the year prior the first examination. Eleven patients, including eight with recurrent thrombosis, received 300-400 mg per day dipyridamole during 1 month to 2 years. Some abnormalities are commonly observed in the whole studied population: lowering of platelet adhesiveness, defective aggregation in the presence of both collagen and ADP 5. 10-5 M; increased level of factor V and mainly factor VIII. Mean platelet factor 3 activity was in the normal range with variations from one case to another. The only unusual feature observed in patients with recurrent thrombosis was an increase of platelet aggregation induced by ADP 0.5. 10-6 M. Neither spontaneous aggregation nor significant abnormality of plasminogen level and plasma antithrombin activity were observed. Under dipyridamole therapy, correction of platelet hyperaggregability was observed in all patients and improvement of platelet adhesiveness in half the studied cases (despite the unchanged anaemia). The treatment significantly decreased the frequency of arteriovnous fistule thrombosis in the six patients observed during two consecutive years, the first one without and the second under treatment: the total number of thrombosis was 18 during the first and 3 in the second period.
Adenosine Diphosphate↗
[Neurotoxoplasmosis. Description of a case of an acquired meningo-encephalitis (author's transl)].
The authors report a case of meningo-encephalitis in a 28 year-old man, who was hospitalized in emergency after a generalized epileptic crisis, which occured after a period of fever and neuro-psychiatric troubles. This was followed rapidly by a comatose stage (third grade). All investigations to find an etiology were unsuccessful except: positive toxoplasmosis serology at 720 IU/ml with IgM fluorescent antibodies, then at 2 600 IU/ml. The level of fluorescent antibodies in the CSF was 1/16. Clinical evolution was favorable with resolution of the comatose stage, and disappearance of the meningitis.
Adult↗
[Immunologically agranulocytosis after ajmaline administration (author's transl)].
The reversible ajmaline induced agranulocytosis is considered as the result of an immunologically mediated destruction. Striking results of leukocyte agglutination test has been observed in the reported case. They suggest that the granulocytic factor involved in this reaction could be in some cases, differentiation membranous antigens. These ones, located on the granulocytic precursors would be detected only during the granulocytic regeneration period.
Aged↗
The part-timers 2. A practical view.
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Nursing Service, Hospital↗
[Simultaneous determination of blood insulin and plasma C-peptide levels. Value during assessment of glucose tolerance, especially in obese subjects (author's transl)].
Insulin secretion is assessed by simultaneous radioimmunological assay of insulin (R.I.I.) and C-peptide (R.I.C.P.) levels under basal conditions, and after stimulation by oral or intravenous glucose administration. Subjects with abnormal glucose tolerance demonstrate an increase in the ratios R.I.C.P. divided by glucose and R.I.C.P. divided by R.I.I. after fasting, increase in R.I.I. and R.I.C.P. occurring later and lasting longer after glucose loading. These anomalies are observed in both obese subjects and those with normal body weights. Simultaneous determination of R.I.I. and R.I.C.P. levels appears of value in a limited number of cases where glucose loading tests do not supply precise information on the quality of glucose tolerance. Obese subjects, in whom abnormal hyperglycemia levels provoked by oral glucose are observed, but in whom the peripheral glucose assimilation coefficient is normal, can be considered to be non-diabetic as shown by the levels of R.I.I. and R.I.C.P. and more particularly by the molar ratio R.I.C.P. divided by R.I.I.
Administration, Oral↗
[Thyroid function in patients with alcoholic cirrhosis (author's transl)].
Total serum thyroxine (T4), total serum triidothyronine (T3), thyrotropin (TSH) and TRH induced TSH release have been measured in 50 clinically euthyroid men with alcoolic cirrhosis and compared to 20 age matched control men in order to determine the thyroid status in cirrhosis. Free serum thyroxin (FT4), free triiodothyronine (FT3) and reverse T3 (rT3), were measured in 34 patients. In these patients, a clinical and biological index was devised to score the severity of the disease. Finally, thyroxine-binding-globulin (TBG) levels were measured in 20 patients. In cirrhotics, the mean total T4 level is normal but the mean T3 level is markedly reduced: FT4 is slightly raised and FT3 is decreased. Serum rT3 levels are often very high and correlated in T3. Basal TSH concentration were slightly significantly higher than normal; the mean magnitude of TSH responses to TRH is comparable to controls but the individual responses are very variable, insufficient or exaggerated, and non correlated with other thyroid function tests. The mean TBG level is also normal and non correlated with total free thyroid hormones. Correlation of thyroid function tests with liver function showed significant correlations between T3, FT3, rT3 or TSH and serum albumin concentration and particularly between T3, rT3 and the clinical and biological index. So the ratio rT3/T3 may be proposed as a valuable index of prognosis and severity of the disease. In conclusion, in alcoholic cirrhosis, thyroid function and regulation are characterized by normal T4 and low T3 levels related to reduced extrathyroidal T4 and T3 conversion levels - and thus maintain the euthyroid state - and by a hypothalamo-pituitary dysfunction. These alterations are related to the degree of liver dysfunction.
Humans↗
Substituting clozapine for olanzapine in psychiatrically stable Parkinson's disease patients: results of an open label pilot study.
Psychosis induced by the standard drugs for treating idiopathic Parkinson's disease (PD) occurs, in the long term, in approximately 5-8% of patients. Until the development of atypical antipsychotic drugs, treatment of this psychosis was extremely limited and unsatisfactory. Clozapine has been reported to be an effective and well-tolerated treatment for this problem. Clozapine, however, is a difficult drug to use as a result of the monitoring system mandated by the Food and Drug Administration because of the potential for agranulocytosis. Treatment with risperidone has been shown to be poorly-tolerated. This article reports on the authors' open label experience with the newest atypical antipsychotic, olanzapine, and the switching of stable patients from clozapine to olanzapine. Nine of twelve subjects were unable to make the transition because of worsened parkinsonism. Most subjects preferred taking clozapine, despite the onerous monitoring procedure.
Aged↗