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Biomedical subjects

C J Tyrrell

Publications and source records attributed to C J Tyrrell.

43 records · Page 3Linked to original sources
PubMed1986

Results of treatment of primary breast carcinoma by radical radiotherapy with artificial pneumothorax.

One hundred and forty-three women with primary breast carcinoma were treated by radical radiotherapy associated with artificial pneumothorax to include the breast and lymphatics en bloc with large opposed fields. Surgery was restricted to local excision or drill biopsy. Most patients received a tumour dose of 5200-5600 cGy in 19-22 fractions over 4 weeks and were followed up for at least 5 years. Local control was achieved in 87% of T1, 52% of T2, 27% of T3 and 23% of T4 tumours. For T2 tumours local control was greater following excision biopsy (75%) than when surgery was more limited (21%). Acute morbidity was mostly minor and self-limiting. The commonest permanent late complication was restriction of shoulder movement in 20 patients. This method although safe and feasible does not offer significant advantages over conventional techniques.

Adult↗
PubMed1986

Megestrol acetate in the treatment of advanced post-menopausal breast cancer.

The effect of megestrol acetate 160 mg daily was studied in 49 previously treated post-menopausal patients with advanced carcinoma of the breast. An overall response of 31% was obtained with 1 complete and 14 partial remissions, chiefly in soft tissue and bone. The median duration of response was in excess of 10 months. Toxicity was minimal and the only notable side effect was mild weight gain without fluid retention. Megestrol acetate is safe and well tolerated, with useful activity in the palliation of advanced breast cancer.

Aged↗
PubMed1977

The role of ultrasound in the assessment and treatment of abdominal metastases from testicular tumours.

The para-aortic region has been investigated with ultrasound in 95 patients with testicular teratoma seen in the testicular tumour unit between 1973 and 1976. The liver was assessed in 110 patients. The technique has provided useful and reliable information. Para-aortic ultrasound can provide more information than existing diagnostic methods and is particularly useful for defining the volume of metastatic nodal masses. Its role should be regarded as complementary to that of lymphography. Ultrasonography is particularly useful to the radiotherapist since it can define the volume and limits of the tumour and thus influence choice of therapeutic approach and radiation planning technique. Ultrasound is also valuable in the assessment of response to treatment and in monitoring the patient during the subsequent follow-up period.

Abdominal Neoplasms↗
PubMed1977

The detection and localisation of abdominal lymph node metastases from testicular teratomas.

Review of the results of treatment of 275 patients with testicular teratomas indicates that the size of para-aortic node metastases as defined by lymphography is closely related to prognosis, and that accurate definition of these metastases is essential in planning treatment. Although para-aortic lymphadenectomy does not appear to be necessary therapeutically or as a staging procedure, excision of residual bulk disease may be required after chemotherapy and radiotherapy. In these cases the residual para-aortic tumour mass should be accurately localised by ultrasonography so the best surgical approach can be used.

Abdominal Neoplasms↗
PubMed1976

The response of lymph node metastases of testicular teratoma to radiation therapy.

The response to radiation therapy of lymph nodes metastases from testicular teratomas has been examined in 117 Stage I and II patients treated between 1962 and 1972. It is not possible to obtain reliable estimates of the percentage Stage I patients with occult retroperitoneal node metastases; however, available evidence suggests that spread of tumour to the lymph nodes has occurred in a proportion (possibly as many as 50%) of patients in this category. Radiation therapy is an effective method of achieving tumour eradication and overall survival results in this group are good (84%). In a smaller group of Stage II patients with unequivocal lymphographic evidence of nodal spread, the effectiveness of irradiation is dependent upon tumour volume. In those patients with metastases 2 centimetres or less in diameter, the results of treatment are similar to Stage I and we have designated this group Stage IIa. In those patients with larger volume metastases, two thirds have developed abdominal node relapse, in most cases associated with distant spread. We have designated this group Stage IIb. The implications of these observations for overall management are discussed.

Follow-Up Studies↗