Search PubMed⌕ Search

Biomedical subjects

C J Thompson

Publications and source records attributed to C J Thompson.

At least 199 records · Page 11Linked to original sources
PubMed1982

Cerebral dissecting aneurysm and intimal fibroelastic thickening of cerebral arteries. Case report.

A 19-year-old white man developed aphasia and right hemiplegia after several falls while waterskiing. Cerebral angiography displayed a ripple appearance and a "string of beads" sign along the left middle cerebral artery, with occlusion or stenosis of most of its branches. The patient died after 6 days, of transtentorial herniation due to massive left cerebral infarction. At necropsy, the infarct was found to be due to a subintimal dissecting aneurysm of the left middle cerebral artery. Multifocal areas of intimal fibroelastic thickening (IFT) were found not only at the site of dissection, but also in the other cerebral arteries, most prominent at the bifurcations of the vessels. A systematic study of cerebral arteries performed in six control cases revealed that IFT was present in a similar distribution to that seen in the patient described. However, the degree of IFT in this patient was greater than in the controls. Some individuals with excessive IFT may be more susceptible to cerebral dissecting aneurysm under a variety of stresses, especially trauma.

Adult↗
PubMed1980

DNA cloning in Streptomyces: resistance genes from antibiotic-producing species.

The biochemical and morphological differentiation of actinomycetes makes them academically and economically interesting. Their secondary metabolites provide the majority of medically and agriculturally important antibiotics (streptomycete genes may also be the primary source of clinically important antibiotic resistance); their complex morphological developmental cycle involves a series of changes from vegetative mycelial growth to spore formation. Recombinant DNA technology would add a powerful new dimension to the analysis of these various aspects of actinomycete biology and would also facilitate the development of industrial strains with increased antibiotic yield, or capable of making new antibiotics. For most of these purposes, cloning of genes within and between actinomycetes is required to study the expression of particular genes in genetic backgrounds defined by mutations of the characters under study. To achieve this, we have now developed a method for molecular cloning involving the transfer of genes between unrelated streptomycetes.

Cloning, Molecular↗
PubMed1980

Position and organization of thalamic cellular activity during diencephalic recording. I. Pressure-evoked activity.

With the aid of a computer graphic display technique, data gathered from exploratory diencephalic recordings in 130 stereotactic operative procedures are presented to show the location and somatotopography of 'pressure'-evoked cellular responses. In addition, the variable position of these responses in relation to common diencephalic landmarks is presented. Our findings indicate that response points are more compact when related to a common posterior commissure (PC) and lie in a sickle-shaped zone 14-16 mm lateral to the midline and 2-8 mm rostral to anatomically the nucleus ventralis caudalis or the nucleus ventralis intermedius. Somatotopographically, face responses were medial to the leg.

Adolescent↗
PubMed1980

Position and organization of thalamic cellular activity during diencephalic recording. II. Joint- and muscle-evoked activity.

With the aid of a computer graphic display technique, data gathered from exploratory diencephalic recordings in 130 stereotactic operative procedures are presented to show the differing topographical distribution of 'joint'- and 'muscle'-evoked cellular activity. In addition, the variable position of these responses in relation to common diencephalic landmarks is presented. Our findings indicate that response points lie in a sickle-shaped zone 14-19 mm lateral to the midline and 2-11 mm posterior to the midcommissural plane. This area correlates closely with the findings of others on the thalamic zone of 1A afferent projections and agrees with the anatomical position of the nucleus ventralis intermedius as plotted by others. When the response points are plotted against a common posterior commissure, a more compact grouping is obtained and 'muscle'- and 'joint'-evoked responses are noted to separate into different zones, with 'muscle' responses positioned slightly anterior and inferior to those for 'joint'. Somatotopographically, face responses were positioned posteriomedially and leg responses anterolaterally.

Afferent Pathways↗
PubMed1980

Topography of 'bilateral-movement-evoked' thalamic cellular activity found during diencephalic recording.

With the aid of a computer graphic technique, data gathered from exploratory diencephalic recording in 130 stereotactic procedures are presented to show the topography of 'bilateral-movement-evoked' thalamic cellular activity. Thalamic cells responding to bilateral voluntary extremity movement were found to occupy a thalamic zone rostral to the zone for 'muscle'- and 'joint'-evoked thalamic cellular activity.

Adolescent↗
PubMed1980

Organization and topography of sensory responses in the internal capsule and nucleus ventralis caudalis found during stereotactic surgery.

With the aid of a computer graphic technique, data gathered from exploratory stimulation of the diencephalon in 130 stereotactic operative procedures indicate that some sensory fibers in the capsule are parallel to motor fibers at basal thalamic levels and occupy a position medial to motor fibers. In addition, stimulus responses which probably represent thalamocortical projections from S II somesthetic thalamus were found to lie in a capsular zone rostral to the motor bundle. The organization of S I somesthetic thalamus was found to agree with the previous finding of Tasker et al. and some of these fibers project within the motor bundle to cortical motor areas.

Adolescent↗
PubMed1979

The position and organization of motor fibers in the internal capsule found during stereotactic surgery.

Data gathered from exploratory stimulation of the diencephalon in 130 stereotactic operative procedures have been studied, with the aid of a computer graphic technique, to show the position and topography of motor responses in the internal capsule. The results obtained indicate that pyramidal fibers are organized into a rostral-caudal face-arm-leg sequence and occupy a short compact band in the caudal third of the posterior limb of the internal capsule. This is in contrast to previous concepts of the position of these fibers in the capsule.

Adolescent↗
PubMed1979

Position of the medial internal capsular border in relation to third-ventricular width.

The position of the medial internal capsular border (lateral thalamic border) in relation to the width of the third ventricle is of considerable importance to stereotactic surgeons. Close estimation of its position from anteroposterior roentgenograms diminishes the possibility of multiple brain penetrations in an attempt to find it by electrophysiological methods. By correlating the position of the medial capsular border found by a stimulation technique, with the width of the third ventricle, in a series of 130 patients, reliable ranges of its position were obtained.

Adolescent↗
PubMed1978

Electrokinetic alteration of the surface of herpes simplex virus infected cells.

Changes induced in the ionic composition of the surface of herpes simplex virus (HSV) infected cells were evaluated by whole cell electrophoresis and isoelectric focusing. The kinetics of the progressive decline in cell electrophoretic mobility (a measurement of negative surface charge density) after infection corresponded to the production of infection virus. The observed HSV-induced increase in cell isoelectric focusing pH demonstrated that the electrokinetic cell surface became ionically more positive. The nature of the ionic changes were investigated using a series of specific reagents in conjunction with cell electrophoresis. Infected cells had 2.4 times surface binding sites for the amino-specific reagent 4-acetamide-4'-isothiocyanostilbene-2,2'-disulphonic acid. A relationship between these virus-induced amino groups and HSV surface antigens was indicated by the similar kinetics of their appearance and electrophoretic neutralization by HSV antibodies.

Antigens, Viral↗