Biomedical subjects
Publications and source records attributed to C J Morley.
A leukaemic child is described who presented with renal failure and gout attributable to hyperuricaemia before the leukaemia could be diagnosed.
Eighteen children with acute myeloid leukemia have been treated with a four-drug protocol using cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine. The initial remission rate overall was 78%. Of 15 children who completed a week's treatment, i.e. one complete cycle, 14 entered complete remission (93%). The median survival was 7 months, and the median survival for those entering remission was 12 1/2 months.
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A daily infusion of 500-1,000 ml of 50% glucose containing 100-120 units of soluble insulin and 100-120 mEq of potassium chloride per litre was given to six patients suffering from hyponatraemia and congestive cardiac failure resistant to digoxin and diuretic therapy. In two patients there was no response, but four showed a striking improvement with a sodium and water diuresis, a rise in plasma sodium level, and in two cases a reversion from atrial fibrillation to sinus rhythm. It is suggested that insulin, glucose, and potassium given by the intravenous route in adequate dosage forms a useful adjunct to the management of severe congestive heart failure.
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Baby Check, a scoring system for quantifying illness in young babies, was developed from a study of 1007 well and ill babies in Cambridge and Melbourne. This paper describes the setting up of field trials to test the performance of the scoring system when used by mothers, GPs and hospital doctors. Preliminary results suggest that the scoring system is attractive, easy to use, useful and of high specificity. Its sensitivity to serious illness is also thought to be high but this will become clearer when the main hospital field trial has been completed.
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