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Biomedical subjects

C J Moore

Publications and source records attributed to C J Moore.

87 records · Page 5Linked to original sources
PubMed1977

One year's experience with a regional hormone assay service.

To provide a service in England and Wales for specialised assays, clinical chemists envisaged a multi-tier system with area, regional, and supraregional laboratories. The Department of Clinical Biochemistry at Addenbrooke's Hospital was established as a regional centre for hormone assays and formal operation started in June 1975. The assays which seemed most suitable for regional development in East Anglia were those for investigating the pituitary-gonad and pituitary-thyroid axes. Most of these were introduced in the first year of operation. A specialised laboratory was not set up: instead, endocrine assays were integrated into a large service laboratory and little expenditure was needed for specialised facilities or staff. The work load of endocrine assays increased markedly during the first year of operation, but the main source of requests was local rather than regional. This lack of use by a region has implications for all three tiers of the specialised service. It suggests that effective centralisation of specialised assays is impracticable unless a dictatorial approach to the problem of rationalisation is made at regional and area level.

England↗
PubMed1975

A comparison of food habits of white perch (Morone americana) in the heated effluent canal of a steam electric station and in an adjacent river system.

Analysis of the stomach contents of 97 white perch, Morone americana, taken from the effluent canal of a steam electric station (S.E.S.) and 106 white perch from adjacent Patuxent River waters indicated similar food habits from September 1970 through August 1971. However, 35% of all white perch taken from the heated effluent canal contained small pieces of coal and cinders, whereas only 3% of the river specimens contained such items in their stomachs. Fly ash and coal dust are present on the bottom of the S.E.S. canal, whereas little such material, if any, can be found on the river bottom in the study area. This suggests the canal fish were actively feeding in the heated effluent and not simply moving into the canal after feeding in the river. No significant difference (Pgreater than0.05) was found between the average wet weight stomach contents of the river and canal fish within the same mouth.

Animals↗
PubMedDate not supplied

PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist.

Inhibition of brain acetylcholinesterase (AChE) can provide relief from the cognitive loss associated with Alzheimer's disease (AD). However, unwanted peripheral side effects often limit the usefulness of the available anticholinesterases. Recently, we identified a dihydroquinazoline compound, PD 142676 (CI 1002) that is a potent anticholinesterase and a functional muscarinic antagonist at higher concentrations. Peripherally, PD 142676, unlike other anticholinesterases, inhibits gastrointestinal motility in rats, an effect consistent with its muscarinic antagonist properties. Centrally, the compound acts as a cholinomimetic. In rats, PD 142676 decreases core body temperature. It also increases neocortical arousal, as measured by quantitative electroencephalography, and cortical acetylcholine levels, measured by in vivo microdialysis. The compound improves the performance of C57/B10j mice in a water maze task and of aged rhesus monkeys in a delayed match-to-sample task involving short-term memory. The combined effect of AChE inhibition and muscarinic antagonism distinguishes PD 142676 from other anticholinesterases, and may be useful in treating the cognitive dysfunction of AD and produce fewer peripheral side effects.

Animals↗
PubMedDate not supplied

The use of a transyndesmotic bolt in the treatment of tibiofibular diastasis: two case studies.

The authors present a brief overview of tibiofibular diastasis and the mechanisms of injury associated with it. This type of injury is frequently misdiagnosed or improperly treated. Two case studies are presented with specific emphasis placed on the use of a transyndesmotic bolt in the reduction of the tibiofibular diastasis. The authors have found this to be more beneficial in the treatment of this condition, as opposed to the traditional use of a transmalleolar screw.

Aged↗
PubMedDate not supplied

Hallux amputation in combination with a lumbar sympathectomy for treatment of a non-healing ulceration in a patient with Buerger's disease.

Buerger's disease is a distal vascular occlusive disease primarily affecting those with a history of tobacco use. Treatment of digital pathology can be quite difficult as a result. This paper discusses a patient who developed an ulceration of the left hallux that did not respond to local wound care and antibiosis. A lumbar sympathectomy was performed in conjunction with a hallux amputation to promote distal vasodilation and enhance the patient's ability to heal.

Amputation, Surgical↗
PubMedDate not supplied

Pathological voice quality assessment using artificial neural networks.

This paper describes a prototype system for the objective assessment of voice quality in patients recovering from various stages of laryngeal cancer. A large database of male subjects steadily phonating the vowel /i/ was used in the study, and the quality of their voices was independently assessed by a speech and language therapist (SALT) according to their seven-point ranking of subjective voice quality. The system extracts salient short-term and long-term time-domain and frequency-domain parameters from impedance (EGG) signals and these are used to train and test an artificial neural network (ANN). Multi-layer perceptron (MLP) ANNs were investigated using various combinations of these parameters, and the best results were obtained using a combination of short-term and long-term parameters, for which an accuracy of 92% was achieved. It is envisaged that this system could be used as an assessment tool, providing a valuable aid to the SALT during clinical evaluation of voice quality.

Acoustic Impedance Tests↗
PubMedDate not supplied

Squamous cell carcinoma: a pedal case presentation.

Squamous cell carcinoma of the foot is a relatively uncommon pedal neoplasm. The authors discuss the etiology, metastatic rate, incidence, morphology, treatment and the histology of this entity. Additionally, the authors present a clinical case report successfully treated by surgical extirpation.

Adult↗