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Biomedical subjects

C J Lockett

Publications and source records attributed to C J Lockett.

27 records · Page 2Linked to original sources
PubMed1980

A simple method for the routine measurement of glycosylated haemoglobin.

The measurement of glycosylated haemoglobin in diabetic patients represents a new approach to long-term control of blood sugar levels. A rapid, simple and accurate assay is described, which requires no costly specialized equipment or highly trained staff. Readily available containers are used as columns. Glycosylated haemoglobin is eluted from the weak cation exchange resin (BioRex 70) by a low ionic strength phosphate buffer pH 6,8 and normal haemoglobin by a subsequent high ionic strength buffer pH 6,4.

Evaluation Studies as Topic↗
PubMed1977

The effects of benfluramate on carbohydrate metabolism in obesity.

Glucose turnover rate, glucose oxidation and lactate production from glucose were investigated in 5 obese subjects using the primed infusion technique, before and four weeks after a course on benfluramate therapy. All subjects lost weight on the drug. Mean glucose turnover rate, but not CO2 and lactate production increased after treatment. The changes in metabolism appear to reflect the combined effects of weight loss and drug action.

Adult↗
PubMed1975

A preliminary report on cephradine.

Plasma cephradine levels were measured after parenteral and oral administration to healthy adults. Plasma cephradine contrations of 7 - 15 mug/ml were measured after 0.5 g had been administered by mouth, and concentrations of 12 - 57 mug/ml were measured after parenteral administration; they fell to 3 mug/ml within 240 minutes except after intramuscular administration. The results of an open clinical trial conducted among 10 patients suffering from urinary tract infections were satisfactory.

Administration, Oral↗
PubMed1975

Plasma triglyceride measurement. A comparison of four commercial methods.

This study investigated the reliability of 4 commercially available methods for the assay of plasma triglycerides. The kit methods were those of Boehringer, Dade, Haury and Oxford. The Boehringer method showed a high degree of precision, acceptable accuracy, and consistent day-to-day reproducibility.

Chemistry, Clinical↗
PubMed1975

The effects of sodium pentosan polysulphate on peripheral metabolism.

Sodium pentosan polysulphate is a polymer of beta-D-xylopyranose which possesses some of the biological properties of the endogenous acid polysaccharides such as heparin. The actions of this compound on plasma lipids, carbohydrate metabolism and fibrinolysis have been studied using the human forearm technique. Ten healthy volunteers were investigated in the fasting state, and blood flow measurements and blood samples were taken before and at 60 and 90 minutes after 100 mg sodium pentosan polysulphate by intramuscular injection. Following administration of the drug, significant changes occurred in plasma triglyceride, free fatty acid (ffa) and glycerol levels. Triglycerides fell (P less than 0,001) and glycerol and FFA rose (P less than 0,001. Changes were largely owing to activation of intravascular lipolysis, although an effect on stored triglycerides was also noted. Fibrinolytic activity also increased after drug administration, but no changes were noted in insulin exchange or glucose metabolism.

Adult↗