Biomedical subjects

C J K Henry

Publications and source records attributed to C J K Henry.

11 recordsLinked to original sources

PubMed2006

The impact of the addition of toppings/fillings on the glycaemic response to commonly consumed carbohydrate foods.

OBJECTIVE: To investigate the influence of the addition of various toppings/fillings on the glycaemic response to baked potato, pasta and toast. DESIGN: Randomised, repeated measures design. SETTING: Oxford, UK. SUBJECTS: Forty normal, healthy subjects (11 males and 29 females) were recruited to the study. Subjects were staff and students from Oxford Brookes University. INTERVENTION: Cheddar cheese, chilli con carne, baked beans and tuna were added to baked potatoes, cooked pasta and toast to determine the effect on glycaemic response. RESULTS: No significant difference was found among the various toppings and baked potato (P=0.06), pasta (P=0.06) and toast (P=0.39). However, the addition of toppings to a carbohydrate-rich food had a consistent lowering effect on glycaemic index (GI). In particular, the addition of cheddar cheese to potato, pasta and toast reduced the GI of the test meal to a value that is considered to be low-GI (39, 27 and 35, respectively). This is particularly notable for potatoes, which, when eaten alone, had the highest GI value of all the staples. CONCLUSIONS: This study has shown that the addition of foodstuffs to the staples baked potato, pasta and toast had a consistent lowering effect on the GI value of that meal. These findings emphasise the importance of investigating the GI of composite meals.

Adult↗

PubMed2005

Basal metabolic rate studies in humans: measurement and development of new equations.

OBJECTIVE: To facilitate the Food and Agriculture Organization/World Health Organization/United Nations University Joint (FAO/WHO/UNU) Expert Consultation on Energy and Protein Requirements which met in Rome in 1981, Schofield et al. reviewed the literature and produced predictive equations for both sexes for the following ages: 0-3, 3-10, 10-18, 18-30, 30-60 and >60 years. These formed the basis for the equations used in 1985 FAO/WHO/UNU document, Energy and Protein Requirements. While Schofield's analysis has served a significant role in re-establishing the importance of using basal metabolic rate (BMR) to predict human energy requirements, recent workers have subsequently queried the universal validity and application of these equations. A survey of the most recent studies (1980-2000) in BMR suggests that in most cases the current FAO/WHO/UNU predictive equations overestimate BMR in many communities. The FAO/WHO/UNU equations to predict BMR were developed using a database that contained a disproportionate number--3388 out of 7173 (47%)--of Italian subjects. The Schofield database contained relatively few subjects from the tropical region. The objective here is to review the historical development in the measurement and application of BMR and to critically review the Schofield et al. BMR database presenting a series of new equations to predict BMR. DESIGN: This division, while arbitrary, will enable readers who wish to omit the historical review of BMR to concentrate on the evolution of the new BMR equations. SETTING: BMR data collected from published and measured values. SUBJECTS: A series of new equations (Oxford equations) have been developed using a data set of 10,552 BMR values that (1) excluded all the Italian subjects and (2) included a much larger number (4018) of people from the tropics. RESULTS: In general, the Oxford equations tend to produce lower BMR values than the current FAO/WHO/UNU equations in 18-30 and 30-60 year old males and in all females over 18 years of age. CONCLUSIONS: This is an opportune moment to re-examine the role and place of BMR measurements in estimating total energy requirements today. The Oxford equations' future use and application will surely depend on their ability to predict more accurately the BMR in contemporary populations.

Adolescent↗

PubMed2005

The Oxford Brookes basal metabolic rate database--a reanalysis.

OBJECTIVE: To produce prediction equations for basal metabolic rate (BMR) derived from weight and height covering the age range from birth to old age. DESIGN: Cross-sectional data on BMR, sex, age, weight, height, ethnicity and measurement technique from the Oxford Brookes BMR database. SETTING: Worldwide. SUBJECTS: Data for 13,910 men, women and children from 174 papers published between 1914 and 2001. RESULTS: Absolute and proportional regression models were developed for each sex, showing a steep rise in predicted BMR with age until 15 years, more pronounced in males than females, then a gradual fall through adulthood. Predicted BMR increased by 6% and 1.4%, respectively, per standard deviation increase in weight and height. Predicted BMR in Caucasians was 4% higher than in non-Caucasians, though the effect size was sensitive to the inclusion or exclusion of data from certain influential publications. The effect of measurement technique on BMR, closed-circuit versus open-circuit, was small, near 1%. CONCLUSIONS: It is possible to develop prediction equations that avoid splitting the data into arbitrary age groups. Heterogeneity between publications is greater than might be expected by chance, probably due to undocumented differences in technique.

Adolescent↗

PubMed2005

Does eating environment have an effect on food intake in the elderly?

Identical meals were prepared and served to 49 elderly subjects (mean age 74.3 +/- SD 7.7 years) in two different eating environments. The improved environment was a state of the art training restaurant and the standard environment was a staff canteen. Each subject was served an identical meal in both environments. The energy intake of each meal consumed was determined using the weighed intake method. There was a significant difference (p < 0.001) in the energy intake in the elderly between the improved (4894 +/- 613 kJ) and standard (4536 +/- 620 kJ) eating environments. Eating environment has a positive effect on the energy intake of elderly subjects. Changes to eating environment may be a useful way to improve energy intake in the elderly.

Aged↗

PubMed2004

The potential impact of soil ingestion on human mineral nutrition.

Geophagia, the intentional and repeated ingestion of soil material, is a complex eating behaviour with incomprehensible aetiology. It is generally assumed that geophagia may help supplement mineral nutrients and thus should not be dissuaded, particularly in subsistence communities. This is largely based on the assumption that a large proportion of mineral nutrients in geophagic materials is potentially available for absorption in the body. We tested this hypothesis on five soils collected from geophagia-prevalent communities by using an in vitro soil ingestion simulation test that is broadly similar to the gastrointestinal (GI) tract. The results show that, despite the soils being rich in mineral nutrients, soil ingestion, inadvertent or through geophagia can potentially reduce the absorption of already bioavailable nutrients, particularly micronutrients such as Fe, Cu and Zn. These in vitro findings, while disagreeing with the commonly held view of geophagia as a source of nutrient supplementation, are consistent with micronutrient deficiency problems observed in clinical nutrition studies conducted amongst geophagic populations. The work also showed that, in some cases, the ingested soils may become a source of Ca, Mg and Mn, although it is not clear why other similar soils should not release any of these mineral nutrients.

Adsorption↗

PubMed2004

Effect of age and disease on taste perception.

Abnormalities in taste function may contribute to poor dietary intake in the elderly, and in patients with renal failure or cancer. This study examined the effect of age on taste thresholds, and taste thresholds adjusted for age, in patients with renal failure with and without dialysis, and patients with cancer receiving chemotherapy and/or radiotherapy. Three groups of healthy volunteers aged 21-34 (n=26), 36-61 (n=13), and 69-94 (n=24), were recruited for the study on the effect of age. Nineteen patients with chronic renal failure on chronic ambulatory peritoneal dialysis (CAPD) and 11 age-matched chronic renal failure patients not yet requiring dialysis were recruited to examine the effect of chronic renal failure on taste function. Twenty-four inpatients with various types of cancer were recruited from a clinical oncology ward. Taste threshold was measured using commercial flavors supplied by Firmenich (pork, beef) and the ascending forced-choice method. Results showed that taste threshold increased with age. No abnormality in taste threshold was observed in patients with chronic renal failure with and without dialysis, and in patients with cancer. However, altered taste occurred in a large number of these patients. Abnormal taste function is present in healthy elderly people, and in patients with chronic renal failure and cancer. The nature of the abnormality differs among these groups, consisting of elevation of taste threshold in the elderly, and dysgeusia in those with disease.

Adult↗

PubMed2003

Sexual dimorphism in fat patterning in a sample of 5 to 7-year-old children in Oxford.

It is now well recognised that, in addition to total body fat, fat distribution is a major risk factor for cardiovascular disease and insulin resistance/diabetes in both adults and children. Traditionally, sexual dimorphism in fat patterning has been regarded as occurring at puberty. The aim of this study was to investigate gender differences in fat patterning in a group of children in Oxford. Anthropometric data was collected for 95 girls and 93 boys aged 5-7 years. Body mass index, percentage body fat and fat patterning indices were calculated using skinfold thickness measurements. While girls at this age had significantly larger percentage body fat and skinfolds, the fat patterning indices showed no differences between genders and no indication of greater truncal adiposity. The boys had a larger mean waist-hip ratio (0.96+/-0.04) compared with the girls (0.93+/-0.04) (P<0.001). The larger ratio in boys was the outcome of the smaller hip circumference in the boys reflecting less gluteal adiposity. This suggests that even at this young age there is clear evidence of sexual dimorphism in fat patterning, with girls showing greater subcutaneous adiposity mainly contributed by gluteal fat. The present study confirms the findings of American and European workers that sexual dimorphism of fat patterning in children is present at 5-7 years of age. Second, that these differences in fat patterning can be detected using simple anthropometric measurements such as hip circumference and skinfold thicknesses. The significance and importance of hip circumference measurements in predicting health outcome is an area that merits further investigation.

Adipose Tissue↗

PubMed2003

Evaluation of a pilot school programme aimed at the prevention of obesity in children.

This paper describes the development, implementation and evaluation of a school- and family-based intervention to prevent obesity in children aged 5-7 years. In addition, the efficacy of three different intervention programmes was compared. Children aged 5-7 years (n=213) were recruited from three primary schools in Oxford and randomly allocated to a control group or one of three intervention groups: nutrition group, physical activity group, and combined nutrition and physical activity group. The setting for the interventions was lunchtime clubs, where an interactive and age-appropriate nutrition and/or physical activity curriculum was delivered. The intervention lasted for 20 weeks over four school terms (approximately 14 months). Children's growth, nutrition knowledge, diet and physical activity were assessed at baseline and at the end of the intervention. Significant improvements in nutrition knowledge were seen in all children (p<0.01) between baseline and post-intervention, and results were highly significant in the nutrition and combined group (p<0.001). Overall, fruit and vegetable intake increased significantly (p<0.01 and <0.05, respectively), with changes seen in fruit consumption in the nutrition group (p<0.05) and the control group (p<0.05) in particular. No significant changes in the rates of overweight and obesity were seen as a result of the intervention. Gender differences were not detected in the majority of assessments and there was no clear effect of programme type per se. This pilot study has demonstrated that school may be a suitable setting for the promotion of healthy lifestyles in children, but requires replication in other social settings. Future initiatives should be long-lasting, multi-faceted and sustainable, involving all children in a school, and should target the whole environment and be behaviourally focused. The ultimate goal of any such programme is to lead to positive behaviour change which will have a beneficial effect on long-term health. Successful targeting of the family remains a challenge to such interventions.

Child↗

PubMed2003

New predictive equations for estimation of basal metabolic rates of adolescents: tropics versus temperate.

The energy and nutritional requirements of adolescents are influenced primarily by the growth spurt that occurs at puberty, and also by the need to maintain adequate levels of physical activity. Predictions of BMR have gained attention since the publication of the FAO/WHO/UNU (1985) expert consultation report, which adopted the principle of relying on energy expenditure rather than energy intake to derive requirement of individuals. While the report predicts BMR accurately in many individuals from temperate climate, they are said to be less accurate in predicting BMR in populations living in the tropics. The collation of worldwide data on basal metabolism indicated that, relative to adults, there was a paucity of data in other age groups including the adolescents. Although several BMR studies among children had been reported in the 90's, the data in normal weight children are almost exclusively from small control groups in obesity studies. Furthermore, we know little as to whether BMR of children differs in differing climatic conditions. This paper presents predictive equations for estimating BMR from a two-centre study, Bangi (Malaysia) and Oxford (UK) and to compare the results with the currently used predictive equations.

Adolescent↗

PubMed2002

Nutritional losses and gains during processing: future problems and issues.

Developments in food technology and nutrition today are shaping our food supply in an unprecedented way. They have not only helped produce a variety of foods with varying taste and texture but also optimally retain the nutritional quality of food. Increased use of novel ingredients in the future manufacture of foods is likely to reduce the amount of micronutrients available in our diet. To combat this, food fortification may be more widely used. Collaboration between food technologists and nutritionists is imperative if we are to see the continued manufacture of wholesome food.

Food Analysis↗

PubMedDate not supplied

Use of low-glycaemic index bread to reduce 24-h blood glucose: implications for dietary advice to non-diabetic and diabetic subjects.

The present study investigated the effect of a simple dietary change on 24-h blood glucose. In a randomized cross-over design, 10 healthy subjects were prescribed a low-glycaemic-index (LGI) diet and a high-glycaemic-index (HGI) diet. The diets were identical with the exception of the type of bread consumed (LGI or HGI). Glucose concentrations over 24 h were measured using a continuous glucose monitoring system. The LGI diet resulted in a lower mean glucose response compared with the HGI diet over 24 h (P=0.135), during the day (P=0.171) and at night (P=0.100). Similarly, the 24-h, daytime and overnight incremental area under the curve for glucose following the LGI diet was consistently lower than following the HGI diet (P=0.093, P=0.132 and P=0.061, respectively). The results demonstrate how a very simple dietary change can favourably alter overall blood glucose concentrations. Such small modifications to the diet, if adopted in the long term, could improve glucose control and consequently reduce the risk of chronic disease in both diabetic and non-diabetic individuals.

Adolescent↗