Biomedical subjects
Publications and source records attributed to C J Hutton.
A case is reported in which a congenital posterolateral diaphragmatic hernia of the Bochdalek type was the cause of sudden unexpected death in a 22-month-old girl. This case shows that not all late-presenting diaphragmatic hernias have a favorable prognosis.
A young married couple committed suicide by hanging, using an unusual arrangement in which the weight of the other partner's body was essential in successfully completing the suicide. Suicide pacts are unusual and the following case history illustrates features that are somewhat atypical, even considering the infrequent nature of such events.
This study investigated behavioural problems (as rated by mothers) in 38 children who had been suddenly bereaved of an infant sibling between 3 and 27 months previously. These children were compared with 40 children matched on age, gender, family composition and social background. Bereaved siblings were reported to have a prolonged and significantly elevated rate of non-specific behavioural problems. It is argued that, either the bereaved children's problems were real, or bereaved mothers' perceptions of their surviving children were significantly distorted. In either case, there is serious cause for concern about the welfare of children in families bereaved by Sudden Infant Death Syndrome.
The toxicity of benzene is well established, particularly its chronic effects on the hematopoietic system and its role as a carcinogen. Acute effects are known but less well documented. This case report describes three cases of acute benzene poisoning resulting from an industrial accident aboard a chemical cargo ship. Complete autopsies were performed on all three victims, who showed evidence of cutaneous, respiratory and cerebral injury. In addition, body fluids, brain, body fat, liver and lung were analyzed for benzene, levels of which were consistent with the lipid soluble nature of benzene, although body fat showed better correlation with blood levels than brain, liver or bile.
We describe an in vitro selection procedure for oligodeoxynucleotide-directed mutagenesis, which produces mutants at frequencies of greater than 90%, facilitating the identification of mutants directly by nucleotide sequencing. The method is based on the selective methylation of the mutant strand by the incorporation of 5-methyl-dCTP. Restriction endonuclease digestion of the resulting hemimethylated DNA with MspI results in the nicking of only the nonmethylated-parental strand. The parental strand is removed by treatment with exonuclease III. The mutants are recovered by transformation of a mcrAB strain of Escherichia coli with the nascent strand.
1. A significant increase in the activity of serum cholinesterase and concentration of dextran sulphate precipitable lipoproteins, cholesterol and triglycerides was observed in sixteen children with a diagnosis of nephrotic syndrome when compared with the values obtained in 22 other normal children of comparable ages. 2. In 7 children with nephrotic syndrome serum concentrations of beta-lipoprotein and cholinesterase were markedly higher in the acute stage compared to the convalescent stage. A working hypothesis is proposed to explain the hyperlipoproteinemia in nephrotic syndrome.
A patient admitted to this hospital with Parathion poisoning had a marked reduction in serum cholinesterase activity and concentration of low density lipoprotein. The enzyme and the lipoprotein levels returned to normal with clinical recovery. Guinea pigs treated with phospholine iodide showed depressed levels of serum cholinesterase and beta-lipoprotein. It is suggested that the decrease in beta-lipoproteins is due to the decrease in cholinesterase activity.
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