Search PubMed⌕ Search

Biomedical subjects

C J Henry

Publications and source records attributed to C J Henry.

At least 55 records · Page 3Linked to original sources
PubMed1994

Pharmacokinetics and tolerance of weekly OXYGENT CA infusions in the dog.

This study determined the OXYGENT CA (90% w/v perflubron emulsion, Alliance Pharmaceutical Corporation) dose necessary to achieve a 3-4% fluorocrit, and the tolerance of this dose administered once per week for four weeks to dogs. This study simulated OXYGENT CA use as a radiosensitizing agent. Six adult dogs were administered 6 ml/kg OXYGENT CA once per week for 4 weeks. Blood samples were collected following infusion, until fluorocrits were < or = 0.5%. One week after the fourth infusion, three dogs were necropsied. Liver biopsies were obtained from the remaining three dogs which were monitored 12 additional weeks. All dogs achieved fluorocrits > 3.0% (3.5-5.1%) with the 6 ml/kg dose. A 3 ml/kg dose did not provide a fluorocrit > 3.0%. Serum bilirubin concentrations were elevated at 24-hour sampling times and declined within 72 hours. Elevations in ALT, SAP, and bile acids were noted. Splenic and hepatic microvasculature fibrosis occurred in the long-term study dogs. Thrombocytopenia occurred in 5/6 dogs, necessitating exclusions of one dog from 2 infusions. However, 3/5 thrombocytopenic dogs had titers for Ehrlichia sp., which elicits thrombocytopenia. Therefore, we cannot conclude the effect of OXYGENT CA on platelets.

Animals↗
PubMed1994

A re-examination of basal metabolic rate predictive equations: the importance of geographic origin of subjects in sample selection.

OBJECTIVE: The study of geographic differences in basal metabolic rate (BMR). DESIGN: A retrospective analysis of two large BMR databases, namely those of Schofield et al. (1985; Hum. Nutr.: Clin. Nutr. 39C, Suppl. 1, 5-41) and Henry and Rees (1988; Comparative nutrition, pp. 149-159). SUBJECTS: The pooled database from the above sources comprised 7737 individual measurements. The largest sub-set of males and females were the 18-30-year-olds (n = 2999 and n = 874 respectively), this group was selected for analysis. INTERVENTION: Least-squares linear regression equations were derived for groups of subjects according to the most common geographic regions represented in the data (North Europeans and Americans, Italians, Indians and Chinese). The method of Rees & Henry (1988) was used to compare these equations over a range of body weights. RESULTS: Regression equations for Italian males and females were significantly greater than other groups over almost the entire body weight range tested. CONCLUSIONS: Italian subjects comprise 45% of the Schofield et al. (1985) database which may therefore be biased and in need of reassessment.

Adolescent↗
PubMed1994

Hematological and clinical responses to combined mitoxantrone and cyclophosphamide administration to normal cats.

The purpose of this study was to examine the feasibility of a combination chemotherapy protocol ("CYCLONE") in cats, utilizing mitoxantrone and cyclophosphamide. Three normal adult cats were administered mitoxantrone (6.5 mg/m2 intravenously) and cyclophosphamide (100 mg/m2 intravenously) every 21 days for a total of three doses. Individual white blood cell count nadirs (range, 2.0-9.5 x 10(9)/L) and neutrophil count nadirs (range, 0.3 to 5.0 x 10(9)/L) occurred between days 2 and 10 after each dose of chemotherapy. Mean white blood cell count nadirs (range of mean, 5.5 to 8.4 x 10(9)/L) occurred between days 6 and 8, as did the mean neutrophil count nadir (range of mean, 1.7-4.0 x 10(9)/L). Side effects were limited to transient appetite suppression in one cat and loose stools in two cats. Myelosuppression and gastrointestinal side effects were comparable to those observed with single-agent mitoxantrone protocols. Further investigation of this protocol is warranted.

Animals↗
PubMed1993

Content of worker notification.

This article summarizes discussions held during the workshop on the issue of the content of worker notification messages and related topics. The workshop itself involved a number of sessions where participants formed small groups. This article represents a distillation of the summary reports by the rapporteurs from each group. It is not intended as a complete review of this issue. Rather, it presents some of the concerns that arose during freewheeling discussions, with the idea that the points raised may help others to think about some of the issues involved.

Communication↗
PubMed1993

Basal metabolic rate in human subjects migrating between tropical and temperate regions: a longitudinal study and review of previous work.

A review of the studies of basal metabolic rate (BMR) in human subjects migrating between tropical and temperate countries is presented. Such an analysis showed conflicting results of BMR in tropical migrants when expressed as BMR/kg/d. Much of this confusion may be attributable to experimental design and poor selection of subjects. A longitudinal study of BMR in 18-30-year-old males migrating for the first time from a tropical to a temperate country (the UK) was undertaken to address disparities seen in the earlier reviewed work. BMR was measured in tropical migrants and their temperate resident peers serially from 2 to 3 weeks post-migration to up to 6 months later, making advances on previous studies which did not measure BMR so promptly post-migration, or conduct serial measurements. The tropical migrants recruited in this investigation were of high socioeconomic status and well nourished. BMR/kg/d was similar in tropical migrants and temperate residents, there being no time trend in either group through the course of the study. The BMR of both groups was similar to that of populations born and resident in temperate regions, in contrast to the lower BMRs of born and resident tropical peoples reported in the literature. It is suggested that these lower BMRs are the result of a different relationship of BMR with body weight in individuals who are undernourished and/or of low socio-economic status, the corollary of which is a lower body weight, stature and body mass index.

Adolescent↗
PubMed1993

Early-onset leukopenia and severe thrombocytopenia following doxorubicin chemotherapy for tonsillar squamous cell carcinoma in a dog.

Doxorubicin is reported to cause myelosuppression, with a white blood cell count nadir occurring between day 7 and day 10. Thrombocytopenia is less severe and occurs between days 3 and 8. This report presents an early onset of leukopenia (day 5) and a severe thrombocytopenia (4000 platelets/microliter) (day 6) associated with doxorubicin administration for treatment of recurrent tonsillar squamous cell carcinoma in a dog.

Animals↗
PubMed1992

Salivary mucocele associated with dirofilariasis in a dog.

Salivary mucocele associated with dirofilariasis was diagnosed in a dog with a mass in the cranioventral cervical region. The diagnosis was based on the finding of microfilariae in fluid aspirated from the mucocele, immunoassay confirmation of circulating Dirofilaria immitis antigen, and the finding of an adult filariid within the mucocele. Drainage of the mucocele and treatment of the D immitis infection resulted in resolution of the mucocele and dirofilariasis.

Animals↗
PubMed1992

Estimates of metabolic adaptation in women living in developing countries: technical limitations.

The measurement of food intake has long been used to describe 'adaptation' to low energy intakes in certain tropical peoples. However, the methods available to quantify food intake are unlikely to reflect accurately real energy intakes in free living peoples. Alternatively, estimating energy expenditure shows some promise--particularly the measurement of basal metabolic rate (BMR). The BMR may be measured effectively in males, but females show wide intra-individual variation in BMR during their menstrual cycle, which makes BMR measurements more difficult to interpret in the context of adaptation. The use of double-labelled water may be the only method suitable to quantify and define 'adaptation' to low intakes in women.

Adaptation, Physiological↗
PubMed1991

Approaches for assessing health risks from complex mixtures in indoor air: a panel overview.

Critical to a more definitive human health assessment of the potential health risks from exposure to complex mixtures in indoor air is the need for a more definitive clinical measure and etiology of the health effects of complex mixtures. This panel overview highlights six of the eight presentations of the conference panel discussion and features a number of the major topical areas of indoor air concern. W. G. Meggs assessed clinical research priorities with primary focus on the role of volatile organic chemicals in human health, recognizing the areas where definitive data are lacking. By recognizing many types of chemical sensitivity, it may be possible to design studies that can illuminate the mechanisms by which chemical exposure may cause disease. The critically important topic of multiple chemical sensitivity was discussed by N. A. Ashford, who identified four high risk groups and defined the demographics of these groups. P. A. Schulte addressed the issue of biological markers of susceptibility with specific considerations of both methodological and societal aspects that may be operative in the ability to detect innate or inborne differences between individuals and populations. Three case studies were reviewed. H. Anderson discussed the past and present priorities from a public health perspective, focusing on those issues dealing with exposures to environmental tobacco smoke and formaldehyde off-gassing from materials used in mobile home construction. J. J. Osborne described several case studies involving wood smoke exposure to children, with emphasis on the significantly greater occurrence of chronic respiratory symptoms and acute chest illness for children from homes heated with woodburning stoves.(ABSTRACT TRUNCATED AT 250 WORDS)

Air Pollution, Indoor↗
PubMed1991

New predictive equations for the estimation of basal metabolic rate in tropical peoples.

The measurement of basal metabolic rate (BMR) is an important element in the estimation of energy requirements in man. Based on a survey of 2822 BMR measurements conducted in the tropics, a series of new predictive equations to estimate BMR in tropical peoples is presented. These new equations based on bodyweight show that the current FAO/WHO/UNU predictive equations overestimate BMR of peoples living in the tropics by an average of 8 per cent, and by up to 11.5 per cent for males over 30 years old. These differences were significant over between 65 and 100 per cent of the normal bodyweight range found in our data, for both males and females over 10 years old. However, for younger ages, 3-10 years, the FAO/WHO/UNU equations predicted BMR quite accurately. The inclusion of height made no significant difference to the predictive equation. Although caution must be exercised in interpreting these results, it is concluded that the lower BMR in the tropics appears to be a general and genuine phenomenon in adults. Further discussion of energy requirements in tropical peoples must consider these observed deviations in BMR from the FAO/WHO/UNU predictive equations.

Adolescent↗
PubMed1990

Basal metabolic rate in monozygotic and dizygotic twins.

The basal metabolic rate (BMR) was determined in 14 pairs of monozygotic (MZ; 11 females, 3 males) and 12 pairs of dizygotic (DZ; 10 females, 2 males) twins, with mean ages of 22.7 and 26 years. Zygosity was confirmed using DNA fingerprinting. When BMR was expressed as kJ/d, kJ/kg/d and kJ/kg FFM/d significant intra-class correlation coefficients were observed in the MZ twins of 0.82, 0.79 and 0.85, respectively. The DZ twins showed much lower intra-class correlations coefficients of 0.1, 0.07 and -0.04. Although the results of the study suggest a likely genetic component to the variation in BMR, they should be interpreted with caution as heritability estimates vary with the method of calculation. These will be critically discussed in the paper.

Adult↗