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Biomedical subjects

C J Hall

Publications and source records attributed to C J Hall.

At least 37 records · Page 2Linked to original sources
PubMed1987

Ocular cowpox.

Explore the source record for details and available documents.

Adult↗
PubMed1982

Laboratory outbreak of Q fever acquired from sheep.

In April and May, 1981, an outbreak of Q fever occurred in a university department which used gravid sheep for fetal respiratory studies. During the subsequent investigation 91 people were studied and 28 were found to have complement-fixing antibodies to the phase II antigen of Coxiella burneti in their serum. Symptoms compatible with C. burneti infection occurred in 14 of the seropositive patients. The majority of symptomatic infections could be related to the delivery of twin fetuses in one laboratory, but some people remote from this incident who were exposed to sheep in other parts of the building also showed evidence of infection. Those people with serological evidence of recent infection were treated with tetracycline for 4 weeks. Defects were apparent in the facilities being used for the research and the risk of Q fever infection should be borne in mind by groups engaged in work with pregnant sheep.

Animals↗
PubMed1981

Effect of gonadal hormones on the incorporation of [3H]lysine into proteins of human fetal brain.

Samples were obtained from the hypothalamus, temporal lobe and frontal cortex of brains from human fetuses aged 14-22 weeks. Slices were prepared and incubated with estradiol, testosterone or dihydrotestosterone, and the incorporation of [3H]lysine into protein was compared with that of untreated control tissue. Cytosol and crude nuclear subcellular fractions from each area were made and resolution of specific proteins was carried out using a polyacrylamide gel system. Steroid hormones had no detectable effect on total protein synthesis, but incorporation of [3H]lysine into certain low molecular weight proteins of the hypothalamus increased significantly in the presence of estradiol and testosterone. Dihydrotestosterone was inactive. The temporal lobe and frontal cortex were unaffected by the steroid hormones.

Brain↗
PubMed1977

Metabolism of [14C]testosterone by human foetal and adult brain tissue.

The metabolism of [14C]testosterone in vitro by various areas of the human foetal brain has been studied and compared with that of adult brain. The predominant metabolites were 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol, and also androstenedione, and all areas of the foetal brain showed similar activity. In the foetal pituitary gland, the activity of 5alpha-reductase was less prominent than that of 17beta-hydroxysteroid-dehydrogenase. Small quantities of oestradiol-17beta were produced from testosterone by the hypothalamus, temporal lobe and amygdala only, and no aromatization could be detected in the pituitary gland. 5alpha-Reductase activity was much lower in adult brain tissues and no oestradiol was identified in adult temporal lobe tissue.

Adult↗
PubMed1976

Effect of heat acclimatization on intravascular responses to acute heat stress in man.

The effects of a 185-min exposure to 48 degrees C db/33 degrees C wb, on intravascular volume and osmolarity and on intravascular electrolyte, aldosterone, and cortisol concentrations have been studied in five male subjects before and after acclimatization to heat. Changes in the hematocrit and plasma protein concentration indicated that a hemodilution occurred during the first 35 min of the heat exposures, and that this was followed by a hemoconcentration. Although these changes in intravascular volume were not affected by acclimatization, the plasma volume after heat acclimatization was 6.7% greater than before. This increase in plasma volume was associated with an elevation in the ratio [Na]/[K]. However, since plasma osmolarity decreased the intravascular expansion could not be explained in terms of elevated electrolyte levels. Plasma aldosterone and cortisol levels were not affected by heat acclimatization, although both were elevated following exercise in the heat. It is concluded that the adrenal cortex is not an important factor in maintaining a state of heat acclimatization once a salt balance has been achieved.

Acclimatization↗