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Biomedical subjects

C J Falliers

Publications and source records attributed to C J Falliers.

At least 55 records · Page 3Linked to original sources
PubMed1982

Efficacy and safety of triamcinolone acetonide aerosol in chronic asthma. Results of a multicenter, short-term controlled and long-term open study.

Triamcinolone acetonide aerosol (TAA) and a placebo aerosol were compared in a six-week, double-blind multicenter study. Ninety-six steroid-independent asthmatic patients were randomized into two parallel groups. Each patient was evaluated weekly. After four weeks of treatment, those patients treated with TAA showed highly significant (P less than 0.001) improvement from baseline in pulmonary function tests (FEV1, FVC, and FEF25-75%) and in asthmatic symptoms, whereas no significant improvement was observed in those patients who received placebo aerosol. In the TAA-treated patients, 78 percent were rated wtih an excellent or good response, compared with 24 percent in the placebo patients. During the subsequent one-week washout period, mean pulmonary function test values of the TAA-treated group were significantly reduced (P less than 0.0001). Eighty-eight patients continued into the one-year, open-label phase of the study. Highly significant (P less than 0.001) improvement from baseline was observed in pulmonary function tests and in asthmatic symptoms at each bimonthly evaluation during the 12-month segment. Mean plasma-cortisol level changes were not statistically significant. At the end of the long-term study, the performance of TAA was subjectively rated by the investigators (excellent or good in 92 percent of the patients) and by the patients (excellent or good in 89 percent). Mild-to-moderate adverse reactions (sore throat, hoarseness) were reported by six patients during the six-week phase and by ten patients during the 12-month phase. Thus, TAA was a safe and effective treatment in this series of bronchial asthma patients.

Adolescent↗
PubMed1980

Controlled comparison of anew antihistamine-decongestant combination to its individual components.

A new antihistamine-decongestant combination tablet, containing azatadine maleate and pseudoephedrine sulfate, was compared to its individual ingredients and also to placebo, in a double-blind, randomized parallel-group clinical study. Two patient groups were treated, one with seasonal allergic rhinitis for two days during the peak of the ragweed season, and another with perennial allergic rhinitis for an extended six-week period. In both groups the combination was found better than its single components, and all three treatments better than placebo, in relieving the symptoms of allergic rhinitis. A few patients reported a transient drowsiness attributable to azatadine.

Cyproheptadine↗
PubMed1980

Combined vs. single-entity pharmacologic inhibition of induced asthma.

The capacity of single oral doses of theophylline, ephedrine and hydroxyzine, alone and in combination, to prevent antigen-induced changes in airways dynamics was compared in patients with seasonal asthma. Each of the individual components was significantly more effective than placebo. Combinations of theophylline-ephedrine and theophylline-ephedrine-hydroxyzine exerted a significantly greater protective effect than the other treatments. Treatment with theophylline-ephedrine-hydroxyzine was associated with fewer side effects than any other treatment, except hydroxyzine alone.

Adult↗