Biomedical subjects

C J Eriksson

Publications and source records attributed to C J Eriksson.

92 records · Page 6Linked to original sources

PubMedDate not supplied

Effect of adrenalectomy and exposure to corticosterone on alcohol intake in alcohol-preferring and alcohol-avoiding rat lines.

The daily fluid intake of male rats of the alcohol-preferring (AA) and alcohol-avoiding (ANA) lines with simultaneous access to 10% (v/v) ethanol and water was determined during a baseline period (2 weeks), following adrenalectomy (1 week), and for 2 weeks following corticosterone treatment. The results showed that adrenalectomized AA rats decreased their ethanol intake compared to the sham-operated AA controls and that treatment with corticosterone restored the intake of ethanol to that observed during the baseline period. In contrast to the AA rats, there were no alterations in ethanol intake after adrenalectomy and following corticosterone replacement in the ANA rats. These results suggest that corticosterone stimulates ethanol intake in animals with pronounced high preference for ethanol.

Adrenalectomy↗

PubMedDate not supplied

Sober-state cortisol as a predictor of drunken violence.

Basal cortisol levels were compared in prisoners convicted of violent crimes, in men previously convicted of violent crimes but currently not in prison, in non-violent alcoholics, and in randomly selected control males. Most of the violent men were diagnosed with antisocial personality disorder (DSM-III-R 301.70). Morning, afternoon, and evening levels of plasma cortisol were assessed after a minimum alcohol abstinence of 24 h. The imprisoned violent men had significantly lower cortisol levels than the unimprisoned, which may reflect their prolonged alcohol abstinence and/or habituation to chronic stress. The unimprisoned violent men were heavy drinkers and their elevated sober-state cortisol may reflect temporary alcohol withdrawal or acute stress. We suggest that variations in basal cortisol are influenced more by environmental factors than by violent predisposition or antisocial personality disorder.

Alcoholic Intoxication↗