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Biomedical subjects

C J Ellis

Publications and source records attributed to C J Ellis.

At least 91 records · Page 5Linked to original sources
PubMed1985

Exchange transfusion in severe falciparum malaria.

Three cases of severe falciparum malaria with high parasitaemia, one of them complicated by disseminated intravascular coagulation, were treated with exchange transfusion in addition to conventional chemotherapy. All three made a good recovery. There are few previous reports of this treatment which deserves wider attention and further assessment.

Adult↗
PubMed1985

Praziquantel.

Explore the source record for details and available documents.

Clinical Trials as Topic↗
PubMed1985

Rhino-orbital zygomycosis.

A 63-year-old diabetic man presented with sinusitis with orbital and intracranial signs progressing over one week, due to zygomycosis. Despite control of the diabetes, surgical excision of infected tissue and antifungal therapy he died in the fifth week of illness. Pathological study showed extensive fungal infiltration of periorbital structures and mycotic thrombosis of many blood vessels with associated necrosis and infarction of fat and extraocular muscles.

Diabetes Mellitus, Type 2↗
PubMed1985

Infection in immunocompromised patients.

Infection is a common cause of morbidity and mortality in immunocompromised patients for whom diagnosis and management require scrupulous attention to detail and a continuing awareness of the micro-organisms causing infection in a particular environment in different groups of patients. Although uncommon and relatively non-pathogenic organisms may be the cause of infection in these patients most are caused by recognised pathogens. The present review concentrates on infection in the immunocompromised as seen in the United Kingdom.

Aminoglycosides↗
PubMed1984

Comparison of serum amylase pancreatic isoamylase and lipase in patients with hyperamylasemia.

We compared results of measurements of total serum amylase, pancreatic isoamylase, and lipase measurements in patients with hyperamylasemia. Serial measurements of these three enzyme levels in patients recovering from acute pancreatitis indicated that pancreatic isoamylase and lipase were elevated above normal to a greater extent and remained elevated much longer than did the total amylase. This finding indicates an appreciable sensitivity advantage of the pancreatic isoamylase and lipase over total amylase measurement during the recovery phase of pancreatitis. Comparison of pancreatic isoamylase and lipase levels in selected sera indicated a good correlation (r = 0.84) between these two measurements in patients who did not have macroamylasemia. Lipase was normal in sera with amylase elevations due solely to salivary isoamylase. Thus, in nonmacroamylsemic sera, pancreatic isoamylase and lipase appear to be roughly interchangeable markers of the level of pancreatic enzymes in the blood. An advantage of the lipase assay is that this enzyme is normal in hyperamylasemia caused by macroamylasemia, whereas the inhibitor assay indicates that the pancreatic isoamylase is elevated. Development of automated assays for either pancreatic isoamylase or lipase should lead to the routine use of one of these assays in place of the present reliance on total amylase measurements in the diagnosis of pancreatitis.

Acute Disease↗
PubMed1984

Afferent pupillary defect in pineal region tumour.

A patient is described in whom an afferent pupillary defect was an early sign of a tumour in the pineal region. It is suggested that this was due to involvement of the pupillary afferent fibres between the optic tract and pretectal nucleus contralateral to the affected pupil.

Adult↗
PubMed1983

Leprosy in Birmingham--a review.

Twenty-three men and seven women from the West Midlands conurbation (population 2.7 million) have been investigated and treated for leprosy since 1970. The clinical features of the patients at presentation are described with an account of treatment given and the outcome. The pattern of this disease in Britain is different from that seen in the U.S.A. and poses little threat to public health. The disease can be cured by chemotherapy but neuropathy is unlikely to recover if it is a presenting symptom. The diagnosis of leprosy should be considered in all patients who have lived in an endemic area who present with disorders of peripheral nerves or skin. Early diagnosis is essential to minimize nerve damage and resulting deformity.

Adolescent↗
PubMed1982

Cavernous sinus thrombosis.

Four patients with clinical and investigative features suggestive of cavernous sinus thrombosis are reported. Radiological investigations included computed tomography of head and orbits. The problem of clinical and radiological distinction from orbital infection is discussed. Serious intracranial complications developed in two patients and the value of computed tomography in detecting these is stressed.

Adult↗
PubMed1981

The pupillary light reflex in normal subjects.

In 19 normal subjects the pupillary reflex to light was studied over a range of stimulus intensities by infrared electronic pupillography and analysed by a computer technique. Increasing stimulus intensity was associated with an increase in direct light reflex amplitude and maximum rate of constriction and redilatation. Latency from stimulus to onset of response-decreased with increasing stimulus intensity. The normal range for each of these parameters is given and the significance of these results in clinical pupillary assessment discussed.

Adolescent↗
PubMed1981

Study of the possible enteropancreatic circulation of pancreatic amylase in the dog.

The possible existence of an enteropancreatic circulation of amylase was investigated in the dog. Endogenous amylase concentration in pancreatic venous blood was consistently greater than that in arterial blood, indicating a net flux of amylase from the pancreas to blood. Less than 0.02% of the metabolic clearance of 125I-amylase was accounted for by 125I-amylase in pancreatic secretions, indicating a minimal flux of amylase from the blood to pancreatic secretions. The venous-arterial amylase concentration across gut segments containing large quantities of amylase was not significantly different from 1.00, indicating absorption of less than 0.2% of the luminal amylase per hour. No 125I-amylase was detectable in serum after endoscopic instillation of labeled enzyme into the duodenum. These studies demonstrate negligible intestinal absorption of amylase and negligible pancreatic extraction of amylase, indicating negligible enteropancreatic circulation of pancreatic amylase in the dog.

Amylases↗