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Biomedical subjects

C J Dominic

Publications and source records attributed to C J Dominic.

At least 91 records · Page 5Linked to original sources
PubMed1966

Reserpine: inhibition of olfactory blockage of pregnancy in mice.

Failure of pregnancy in newly mated female mice exposed to fresh urine from alien males is prevented by administration of reserpine, at 6.25 micrograms per day per female, on days 1 to 5 post coitum-that is, throughout the period of exposure to male urine and for 2 more days. Since reserpine is known to suppress the inhibitory center in the hypothalamus controlling the release of prolactin, inhibition by reserpine of the blockage of pregnancy provides a strong direct indication of hypothalamic mediation in the male-induced failure of pregnancy in mice.

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PubMedDate not supplied

Testicular toxicity of WIN 18446 in the laboratory mouse.

The effect of oral administration of N,N'=bis (dichloroacetyl)-1, 8-octamethylenediamine (WIN 18446) (200 mg/kg body weight/day, up to 30 days) on the testis of the Parkes (P) strain laboratory mouse was studied. The drug caused reduction in testicular weight and severe atrophic changes in the seminiferous tubules. A duration-dependent effect of the drug was observed on the germ cells. The drug had its initial impact on spermatids followed by spermatocytes, ultimately culminating in the Sertoli cell-spermatogonia syndrome. The drug-induced changes included exfoliation of germ cells, formation of multinucleated giant cells, and vacuolization of cytoplasm and displacement (towards the lumina of the tubules) of Sertoli cell nuclei. Even 75 days after drug withdrawal, testicular weight remained depressed and in 15 to 20% of the tubules there was incomplete recovery of spermatogenesis. Our data indicate that WIN 18446 induces sustained impairment of spermatogenesis by a direct action on spermatogonia or indirectly by affecting the integrity of the Sertoli cells. The Leydig cells remained unaffected in WIN 18446-treated mice.

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PubMedDate not supplied

Changes induced by morphine administration in the hypothalmic neurosecretory system of the spotted owlet, Athene brama Temminick.

The effect of chronic administration of morphine, in gradually increasing doses, on the histology of the HNS of the spotted owlet was investigated. Administration of morphine in low doses (0.25-0.75 mg/day), for 9 days, induced marked depletion of NSM from all regions of the HNS, except the zona externa of the AME. Maximum depletion of NSM was noticed in the HNS of birds treated with morphine for 9 days. Beyond the 9th day, the HNS did not exhibit further depletion of its NSM. Administration of morphine in high doses (1.5-4 mg/day), for 18 days, did not cause depletion of NSM from the HNS. On the other hand there was noticeable increase of the NSM in the HNS over that of the controls. The histological changes in the HNS induced by low doses of morphine are comparable to the changes induced by hypertonic saline administration and are presumably indicative of augmented secretion of the ADH. The accumulation of NSM in the HNS of birds receiving high doses of morphine suggests a decrease in neurohypophysial activity. The results therefore indicate that the effect of morphine on the HNS of the spotted owlet is dose-dependent. The mechanism of action of morphine on the neurohypophysis is briefly discussed.

Animals↗
PubMedDate not supplied

Effect of alpha-chlorohydrin on the epididymis of the Indian palm squirrel (Funambulus pennanti).

The effects of alpha-chlorohydrin administration on the epididymis of the Indian palm squirrel were investigated. The drug induced dose-and duration related regressive histological changes in the three epididymal segments. In spite of the regressive changes in the epididymis, spermatogenesis continued uninterruptedly in alpha-chlorohydrin-treated animals. Treatment with the drug also induced alterations in the levels of epididymal nucleic acids, protein, sialic acid and glycogen. The alterations in the histology and chemical constituents of the epididymis in drug treated animals were completely reversible. Within 21 days after drug withdrawal, epididymal histology and constituents returned to the pre-treatment state.

Animals↗