Biomedical subjects
C J Davis
Publications and source records attributed to C J Davis.
Progress in pathology of tumors of the urinary tract.
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Developments in histopathology of testicular germ cell tumors.
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Distribution of vasoactive intestinal polypeptide binding sites in guinea pig genital tissues.
Vasoactive intestinal polypeptide (VIP) binding sites were localised in sections of guinea pig genital tissues using [125I]VIP and quantitative in vitro receptor autoradiography. A moderate density of binding was demonstrated in the epithelium of the prostate gland, seminal vesicles and in the testes. Moderate to high VIP binding also occurred in the epithelial lining of the oviduct, uterine glands, cervix and vagina. The binding sites appear to have a dissociation constant (Kd) of 0.36 nM and maximum receptor density (Bmax) of 60.5 x 10(-3) fmol/mm2 in sections of the uterine horn. The results indicate that VIP may have a role in the secretory functions of the guinea pig genital tract.
Perforation of terminal ileal appendage of J-pelvic ileal reservoir.
If, during restorative proctocolectomy, the most distal segment of the terminal ileum is not incorporated into the reservoir during J-pouch construction, it will remain as an appendage and may twist upon itself and obstruct. Two cases in which this resulted in significant complications are described.
The multiloculated renal mass: considerations and differential features.
1. Many diverse disease processes may result in a multiloculated renal mass. 2. The term "multilocular cyst" is purely descriptive and should not be used as a specific diagnosis. 3. The management of this diverse group of diseases is controversial. There is insufficient information concerning the accuracy of percutaneous biopsy to permit one to base management decisions on such a biopsy in most of these masses. The cystic diseases (septated cyst, localized cystic disease, segmental multicystic kidney) should be managed conservatively. Most cases of arteriovenous communication are readily diagnosed angiographically and managed by vascular occlusive techniques or by surgery. The remaining multiloculated renal masses usually require surgical removal for histologic diagnosis or definitive therapy or both.
Immunopathology of germ cell tumors of the testis.
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Progress in pathology of carcinoma of prostate.
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Cystic renal cell carcinoma.
Cystic renal cell carcinoma includes any malignant neoplasm of renal tubular epithelium which presents as a fluid-filled mass. Approximately 15 per cent of cases of renal cell carcinoma will be cystic on radiologic and pathologic examination. The clinical features of cystic renal cell carcinoma are similar to those which are solid. The radiographic and pathologic findings of cystic renal cell carcinoma are often more confusing and less specific than the findings of renal cell carcinoma which are predominantly solid. There are four basic pathologic mechanisms resulting in cystic renal cell carcinoma: intrinsic multiloculated growth; intrinsic unilocular growth (cystadenocarcinoma); cystic necrosis; and origin from the epithelial lining of a preexisting simple cyst. There are three basic radiologic patterns of cystic renal cell carcinoma: unilocular cystic mass, multiloculated cystic mass, and discrete mural nodule in a cystic mass. Cystic renal cell carcinoma is often extremely difficult to differentiate from non-neoplastic, benign neoplastic, and other malignant neoplastic masses utilizing radiologic studies alone. This review presents the clinical, pathologic, and radiographic features of cystic renal cell carcinoma and discusses its radiologic differential diagnosis.
Tumors and tumor-like lesions of the kidney.
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Psychopathology of eating disorders: a controlled comparison of bulimic, obese, and normal subjects.
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Influenza vaccination and Guillain-Barré syndrome.
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Xanthogranulomatous pyelonephritis: sonographic--pathologic correlation of 16 cases.
Xanthogranulomatous pyelonephritis (XGP) is an uncommon renal inflammatory disease characterized by the destruction and replacement of normal parenchyma by sheets of lipid-laden histiocytes. The process may be diffuse or segmental. Sonograms of 16 cases of XGP (13 diffuse, three segmental) were retrospectively reviewed and correlated with their pathologic findings. The typical case of diffuse XGP demonstrates the following: renal enlargement, replacement of normal architecture by multiple fluid-filled masses, pelvic contraction or only moderate separation of the central echo complex, and a pelvic calculus. Although most cases have a large staghorn calculus, its sonographic demonstration may be difficult, perhaps as a consequence of peripelvic fibrosis. Atypical cases of diffuse XGP mimic pyelonephrosis with massive hydronephrosis and fluid--debris levels. In these atypical cases, a staghorn calculus is often conspicuously absent. Segmental XGP is recognized as an area of parenchymal destruction surrounding one calyx or one pole of duplication. Segmental XGP should be distinguished from focal xanthogranulomatous inflammation of the kidney, which is a distinct pathologic entity (cortical location, no pelvic communication, absent pyelitis). When typical gross pathologic features are present, sonography should make possible accurate identification of diffuse and segmental XGP.
Epithelial abnormalities of urinary bladder.
We have called attention to certain epithelial lesions of the bladder characterized as proliferative, metaplastic, and neoplastic. In the first group are included hyperplasia, von Brunn's nests, papillary cystitis, papilloma and inverted papilloma. The second category includes squamous metaplasia, mucous metaplasia, and tubular metaplasia. These two categories, while benign, are indicative of agitated sick mucosa and may progress to neoplasia. The neoplastic changes consist of carcinoma involving the surface epithelium, von Brunn's nests, papillary cystitis, and/or cystitis cystica.
An investigation of a minimal contact brand fading program for smoking treatment.
Self-help methods are preferred by smokers over clinic-based treatments providing more traditional services. Unfortunately, these more popular methods have not been extremely successful in getting smokers to quit. The poor success rates may be partially related to the lack of structure inherent in these treatment approaches. The present study examined a self-help program delivered to smokers via a written manual and limited duration phone calls--the latter to add structure to the treatment procedures. The results, a 23% abstinent rate, indicate that this approach has some promise for treating chronic smokers.
Assessment of smoking topography generalization across laboratory, clinical, and naturalistic settings.
A three-study series was conducted to examine smoking topography across clinical, laboratory, and naturalistic settings for 24 smokers who were patients in an alcohol treatment program. Experiments 1 and 2 included surreptitious observation of smoking in group therapy sessions (naturalistic), and obtrusive observation of smoking in a smoking clinic setting. The third study added a laboratory smoking condition to the clinic and group conditions. Puffing patterns in clinical and laboratory settings tended to be similar, and both differed from smoking in the naturalistic setting. Subjects generally took more puffs, longer puffs, and had shorter cigarette durations in clinical and laboratory settings than in the naturalistic setting. The implications of these findings for assessment of intake and health risk are discussed.
When low tar cigarettes yield high tar: cigarette filter ventilation hole blocking and its detection.
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