Biomedical subjects
Publications and source records attributed to C J Conti.
The existence of a peculiar structural pattern of complementary villi and pores was observed on the squamous surfaces of palms and soles. These features, which might be considered as acquired and adaptive cell surface modifications, proved to be more conspicuous during a period of rat and human postnatal development.
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The DNA content of the epithelial basal cells of oral lesions was determined by Feulgen microspectrophotometry. The DNA histograms of the radicular cysts showed a definite peak in the diploid range and a slight deviation to the right. The keratocysts also showed a well-defined modal peak in the diploid range; however, another cell population defined a peak in the tetraploid range. In leukoplakias of the oral cavity, two different profiles of DNA distribution were found. Where both the clinical and microscopic traits defined a nondysplastic lesion, the histogram showed a diploid peak and a percentage of cells in diploid-tetraploid range. For the more active lesion, a shift of the mode towards higher values was evident. The microspectrophotometric studies of oral epidermoid carcinomas showed a broad distribution towards the right and ill-defined modal values.
Nucleic acid and proteins of newborn rat tail subjected to local X-irradiation were microspectrophotometrically studied. Feulgen, gallocyanine chrom-alum and naphthol yellow S methods were performed for demonstration of DNA, total nucleic acid and proteins respectively. The amount of proteins and total nucleic acid increases concomitantly with reactional acanthosis. However, the proteins and nucleic acid decrease as from day 3 post-irradiation. A tentative interpretation of the results would point to a giantization of the epidermic cells not only caused by aqueous imbition but also by an actual increase of the cellular protoplasm.
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Seventeen serum samples from patients suffering from monoclonal gammopathies (multiple myeloma, Waldenstrom's disease and idiopathic paraproteinemia) were tested by indirect immunofluorescence techniques for detection of antibodies against autoantigens. Neither serum from patients with multiple myeloma nor that from patients with idiopathic paraproteinemia showed reactions against the different antigens tested. Sera from two of six patients with Waldenstrom's diseases reacted against cytoplasmic proteins of basal and adnexal cells of squamous epithelia. One of the two also reacted with smooth muscle cells. Our studies showed that these antibodies were IgM kappa, therefore corresponding to the monoclonal component. Immunoenzymatic procedures on purified cytokeratin fixed on microtiter plates demonstrated reactions of the two sera against this protein in dilutions of up to 1:80 and 1:120 respectively. Western immunoblotting showed a specific reaction with 52 kD cytokeratin in one of the sera.