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Biomedical subjects

C J Cha

Publications and source records attributed to C J Cha.

At least 55 records · Page 3Linked to original sources
PubMed1977

Free amino acids in tissues of the skate Raja erinacea and the stingray Dasyatis sabina: effects of environmental dilution.

Concentrations of individual free amino acids were determined in various tissues of the skate (Raja erinacea) and the stingray (Dasyatis sabina), and the relationship of cellular free amino acid concentrations to intracellular osmoregulation was investigated by adapting these elasmobranchs to half-strength seawater. Each tissue characteristically had high levels of certain specific amino acids. Skate sing muscle contained high concentrations of sarcosine and beta-alanine, skate heart had high concentrations of taurine, and skate erythrocytes had high levels of taurine and beta-alanine. Amino acid levels in skate plasma were very low. High concentrations of aturine and glutamate were found in stingray brain. Adaptation of skates and stingrays to half-strength seawater was accompanied by significant decreases in concentrations of the major free amino acids in skate wing muscle and erythrocytes and in stingray brain, but not in skate heart. The data suggest that in these elasmobranchs certain specific free amino acids are selectively involved in intracellular osmoregulatory mechanisms.

Adaptation, Physiological↗
PubMed1976

Jejunoileal bypass for morbid obesity: early results and body composition changes in forty-five patients.

Forty-five patients who underwent a 14 by 4 inch jejunoileal bypass for morbid obesity were studied before the operation and at periodic intervals after operation to determine the complications and changes in body composition resulting from this procedure. Body composition studies were determined using 3H2O and 42K. Rapid weight loss occurred in the first 3 months, with a mean loss of 30 percent of excess weight. This weight loss was accompanied by a decrease in exchangeable potassium (Ke) and total body water (TBW) during this interval by 14 and 10 percent, respectively. Although most patients continued to lose excess weight Ke and TBW stabilized at the end of the first year and returned to preoperative values in six patients at the end of 24 months. Analysis of the ratios of body cell mass and total body water to weight shows an improvement of body composition 12 months after operation. Body composition studies permit a quantitative assessment of the nutritional status in patients undergoing jejunoileal bypass. In spite of significant complications (23 percent), surgery for morbid obesity appears to satisfy the objective of allowing desirable loss of fat with relative sparing of muscle and other supporting tissues.

Adult↗