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Biomedical subjects

C Ionescu

Publications and source records attributed to C Ionescu.

142 records · Page 8Linked to original sources
PubMedDate not supplied

Plasma phosphorus and magnesium values during treatment of severe diabetic ketoacidosis.

Plasma phosphorus and magnesium were determined in 76 diabetics, admitted with severe ketoacidosis (pH less than or equal to 7.20, total CO2 less than or equal to 10 mEq/l) before and 24 hours after beginning the treatment, which did not include supplementary phosphorus or magnesium. Phosphorus presented initially high values (1.76 + 0.69 mEq/l) which fell substantially 24 hours after beginning the treatment (0.87 +/- 0.26 mEq/l); magnesium values, initially low (0.76 +/- 0.19 mEq/l), fell still further within 24 hours of treatment (0.64 - 0.16 mEq/l). For phosphorus (and to a lesser extent for magnesium) calculation of the regression line indicated a direct positive relationship with both hydrogen ion concentrations (r = 0.67) and blood glucose (r = 0.73), the differences being statistically significant. The more rapid the decrease in glycemia and correction of acidemia and the greater the amount of glucose administered in the course of treatment, the more marked was the fall of plasma phosphorus and magnesium values.

Adolescent↗
PubMedDate not supplied

Metabolic "responders" and "non-responders" to muscular exercise in diabetes.

The metabolic effects of muscular exercise (bicycle ergometer, 75 watts, 15 min) were studied in 16 healthy controls and 49 diabetics distributed into three groups. The first two groups included insulin-dependent diabetics three hours after administration of insulin (group A, 24 cases) or 12--18 hours after the last insulin dose (group B, 18 cases). Group C included 7 non insulin-dependent diabetics. According to the glycemia response, the patients were listed as: high responders (greater than 20% below the initial values), low responders (10-20% fall) and non-responders (increase or less than 10% decrease). The data obtained show that, in most cases, in the presence of insulin, exercise has a hypoglycemic effect and, in its absence, a hyperglycemic one. To a lesser extent, the fall in glycemia may be attributed to an apparently insulin-independent mechanism. Exercise can only be indicated (in high-responders) or contraindicated (in non-responders) after a routine tolerance test.

Adolescent↗
PubMedDate not supplied

Study of sodium and potassium intake in different categories of healthy subjects.

The usual Na+ and K+ intake was investigated in 436 apparently healthy subjects, 370 men and 66 women, ranging in age from 19 to 56 years, distributed into three lots: 219 from a metallurgical plant, 100 from a military unit and 117 from an unselected population sample. The average Na+ intake amounted to 214 mEq/24 h in the first lot of study, to 224 mEq/24 h in the second and to 203 mEq/24 h in the third, the differences among them being not significant. K+ intake in the three lots was 38 mEq/24 h, 43 mEq/24 h and 49 mEq/24 h, respectively. Na+/K+ ratio reached 5.6 in lot I, 5.2 in lot II and 4.1 in lot III, compared to the unitary ratio in natural foodstuffs. The data obtained demonstrate that Na+ intake in the general population is excessive, while K+ intake is deficient. It is assumed that this might partly account for the great incidence of arterial hypertension.

Adult↗
PubMedDate not supplied

Epidemiological investigations on viral hepatitis in preschool and school communities. Note II. Evaluation of the prophylactic efficiency of standard gammaglobulin administration.

At the beginning of the 1977--1978 schoolyear 10% standard gammaglobulin (0.03 ml/kg body weight) was administered to 974 preschool children and 530 schoolchildren. Representative groups of children were tested serologically and virologically before gammaglobulin administration and 3 months afterwards. No statistically significant reductions of viral hepatitis morbidity were recorded in the protected groups as against controls.

Child↗
PubMedDate not supplied

[The current and future outlook in immunosuppressive therapy for children].

The various cell proportions that form the immune system intervene in the activation of autoreactive cells and in the occurrence of the associated inflammatory process. Advances of the study of the mechanism involved in the autoimmunity, and the development of new immunosuppressive agents used for transplantations have deeply modified the therapeutic approaches. The classic treatment of autoimmune diseases has relied on corticosteroids and immunosuppressive drugs. Now, these new treatments are evaluated on animal models, then controlled in clinical trials. Cyclosporin A has been shown to be effective in several autoimmune diseases. Intravenous immunoglobulins, cytokines, and anticytokines, immunotoxins, monoclonal anti-leukocyte antibodies (CD4, CD25) and soon peptide vaccination constitute the new types of treatments.

Antibodies, Monoclonal↗