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Biomedical subjects

C Ionescu

Publications and source records attributed to C Ionescu.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Protheses of the penis; 130 cases (author's transl)].

The authors report their experience (13 years) with circa 130 operations and over 300 exercises on corpse-penes. From 1966 till 1972 the authors used an unilateral device, with inconstant good results. 1972 to 1975: a bifurcated penile implant made from Teflon with better results, but without firm proximal footings; (76 patients). 1975 to 1977: 73 cases = 26 with the new developped penile implant with one-way articulation and 11 with modified Small-Carrion penile implants. These modern protheses can create a true "phallus" = 130 to 150 mm long. The implants with one-way articulation guarantee solid posterior footings (very important for immissus in vaginam). The technique with the 3 approaches (perineal, praesymphyseal and distal) is described. The presence of a rigidified big penis was no problem for the patients, as long as it can be bent at its base, painless and efficient = potentia satisfaciendi. In doubtful situations the indication for operation should be settled by a team of specialists.

Erectile Dysfunction↗
PubMed1976

Ultrastructural changes in cartilage after intra-articular administration of osmium tetroxide and the sodium salts of fish oil fatty acids (Varicocid).

A clinical and experimental study was carried out on knee joints of rabbits and in humans. In one knee joint of each rabbit 0.3 ml 1% osmic acid or 0.3 ml 5% Varicocid was injected, the remaining uninjected joints serving as controls. The animals were killed after 1 and 24 hours, 15, 45 and 90 days. Study with the electron microscope after osmic acid injection revealed necrosis of the chondrocytes in the superficial layer and upper middle zone. The articulations injected with Varicocid exhibited only slight lesions of the chondrocytes in the upper layer, consisting of dilated rough endoplasmatic reticulum, mitochondria lacking matrix and christae; the electron density of the layer seemed to be diminished. Biopsy of the non-weight-bearing cartilage of the lateral femoral condyle was performed in 4 patients with Rheumatoid Arthritis and arthritis of the knee in the onset stage. Two of these patients received one intra-articular injection of 10 ml 1% osmic acid, 5 ml 2% xylocaine and 50 mg hydrocortisone and the other 2 patients 6 ml 5% Varicocid. Biopsy of the cartilage in the areas adjacent to the site of the first biopsies 1 and 3 1/2 months after treatment with osmic acid and 2 and 3 1/2 months after treatment with Varicocid showed in the first two cases necrosis of the chondrocytes in the superficial layer and upper middle zone of the articular cartilage and depletion of the mucopolysaccharides in the ground substance, revealed by PAS and alcian blue staining. No lesion of the knee joint cartilage was observed in the other two cases. In view of the results obtained, chemical synovectomy with Varicocid can be considered as having received further support.

Animals↗
PubMed1975

[Not Available].

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History, Modern 1601-↗
PubMedDate not supplied

Ultrastructural aspects of the alveolar wall in SIDS.

The aim of this study is to make a comparative analyse between light and ultrastructural lesions of the alveolar wall in SIDS. The study was made on lung specimens collected from autopsy of infants with sudden unexplained death. There were studied histopathologically 10 cases of sudden death. Only in 3 cases were made electron microscopically studies. At light microscope, there were put in evidence interstitial and intra-alveolar oedema and the presence of many parietal and intra-alveolar macrophages. There is a good correlation between light and ultrastructural aspects.

Humans↗
PubMedDate not supplied

[Costal pathology].

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Bone Diseases↗
PubMedDate not supplied

[Stapled anastomoses in colorectal surgery].

The purpose of this paper was to analyze the advantages, indications and results of stapled circular anastomoses in colorectal surgery. In the last four years (1995-1998), fifteen patients underwent stapled anastomoses after Dixon's anterior rectal resection for cancers of upper and midrectum (11 patients), total colectomy with ileorectal anastomosis for malignant familial polyposis (1 patient), segmental colectomy of transverse and descending colon (1 patient with synchronous colic and rectal cancers, having concomitant rectal resection for cancer), previous Hartmann's resection for perforated upper rectal cancer (1 patient) or distal sigmoid diverticulitis (1 patient). The anastomoses have been performed in end-to-end fashion (11 patients), according to the Knight's technique (2 cases) or in side-to-end fashion (2 patients). As most frequent associated technique with stapled anastomoses, anterior rectal resection for cancer was performed with 2 cm of clearance beyond the macroscopic margin of tumor. Distal margin of resection was histologically verified and it proved to be free of tumor cells. There was no operative mortality. Anastomotic leakage occurred in three patients because of imperfection of stapled anastomosis (2 cases) or after local irradiation (1 case). Spontaneous closure was seen in one patients. The other two patients needed reoperation for suture or colostomy. Late clinical, endoscopic and X-ray controls did not discover local recurrences. Functional results were good in terms of stool frequency and continence. In conclusion, stapled fashioned anastomoses have the main indication in sphincter saving Dixon's and Hartmann's procedures. In these cases, stapled anastomoses are easier than manual technique, reduce operative time and improve suture reliability.

Adenocarcinoma↗
PubMedDate not supplied

Ultrastructure of the lymph node after prolonged immunization.

Changes in the fine structure of the lymph nodes were studied after prolonged immunization with heterologous sera. Hypertrophy of the lymph node cortex and paracortex frequently occurred, as well as development of the zone lying next to the lymphatic sinuses, postcapillary venules, veins and arteries in the cortex, paracortex and medulla, which is mainly bursa-dependent. Worthy of note was the presence of germinative centers characterized by large ribosomes, rich cells and macrophages. Similar aspects were observed in splenectomized animals undergoing prolonged immunization. Particular aspects of immunologic activity in the lymph nodes were noticed in the animals which had received an immunosuppressive treatment during immunization. The significance of the morphological alterations in the fine structure of the lymph nodes is correlated with the serological findings.

Animals↗
PubMedDate not supplied

Renal pathomorphologic aspects in cirrhogenic diseases of the liver.

The pathomorphogenesis of renal lesions in the course of cirrhogenic diseases of the liver was studied on a human and experimental material. The development of membranoproliferative glomerulopathy, of tubular lesions, interstitial reactive infiltrates and sclerosis processes in the advanced stages of cirrhosis were observed. An important role in the determining of these lesions was played by immunologic perturbations in the entire organism.

Adolescent↗