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C Ingram

Publications and source records attributed to C Ingram.

At least 37 records · Page 2Linked to original sources
PubMed1996

The research utilization process: the use of guided imagery to reduce anxiety.

In the rapidly changing health care environment, nurses need to keep current with developments, assess their applicability to practice, and make changes where appropriate. There is evidence that nursing research is underutilized and that a considerable gap exists between nursing research and practice (Bostrum & Suter, 1993; Brett, 1987; Sokop & Coyle, 1990). The objectives of a study carried out on a bone marrow transplant unit in a teaching hospital were to: (1) by introducing a framework for research-based care, enhance research utilization in a selected setting, and (2) evaluate the outcomes of research utilization on a specific clinical nursing problem chosen by nurses and researchers. This paper describes the research utilization process and its outcomes, presents an evaluation of the participatory approach from the perspective of the participating nurses, and discusses facilitators and barriers to research utilization. Guided imagery was the intervention used to decrease patient anxiety.

Adult↗
PubMed1995

ccrA1: a mutation in Streptomyces coelicolor that affects the control of catabolite repression.

The regulation of carbon utilization is of central importance in the gene expression pathways for both morphological development and antibiotic production in Streptomyces species. We report the identification and characterization of a mutation in Streptomyces coelicolor, ccrA1, that affects the expression of several catabolite-controlled promoters. ccrA1 mutants are altered in expression of galP1, the glucose-sensitive, galactose-dependent promoter of the galactose utilization operon; in expression of the glycerol utilization operon, which is glucose sensitive and glycerol dependent; and in expression of chi63, the glucose-sensitive chitin-dependent promoter of a gene involved in chitin utilization. ccrA1 has no effect on the expression of galP2, a promoter that directs constitutive transcription of the galE and galK genes. ccrA1 maps to a region of the S. coelicolor genome which distinguishes it from other mutations known to be involved in catabolite control. We suggest that ccrA1 identifies a gene whose product may be involved in the general regulation of carbon catabolite repression in this complex bacterium.

Chromosome Mapping↗
PubMed1995

The glucose kinase gene of Streptomyces coelicolor is not required for glucose repression of the chi63 promoter.

Glucose kinase is required for glucose repression of several catabolite-controlled genes in Streptomyces coelicolor and certainly plays an important role in glucose repression in these organisms. We report here that glucose kinase null mutants of S. coelicolor retain transcriptional regulation of the chitinase 63 gene, which encodes an enzyme involved in chitin utilization. Transcription of chi63 is glucose sensitive and chitin dependent. We suggest that glucose repression of chi63 is independent of glucose kinase and that there may be more than one mechanism of glucose repression in Streptomyces spp.

Chitinases↗
PubMed1995

Effect of a microaerosol barrier filter on the measurement of lung function.

STUDY OBJECTIVE: A disposable barrier filter (Pall Biomedical, United Kingdom) was developed to prevent the contamination of lung function equipment in clinical use. The aims of this study were to examine its resistance characteristics and to determine the effect of the filter on clinical measurements of lung function. MEASUREMENTS: Twenty-one randomly selected patients and four normal subjects had lung function measured with and without the filter between the mouth and measuring equipment. Measurements of ventilatory function were made with a pneumotachograph (Lilly; Hoechberg, Germany), total lung capacity and airway resistance by constant volume plethysmography, and diffusing capacity for carbon monoxide by the single breath method. Resistance was determined in five unused filters over the flow range 1 to 12 L/s and at a single flow rate (12 L/s) just after a normal subject expired 20 forced vital capacity (FVC) breaths through each of them. RESULTS: The resistance (mean +/- SD) of unused filters was 0.19 +/- 0.02 cm H2O/L/s at 1 L/s and increased linearly to 0.56 +/- 0.02 cm H2O/L/s at 12 L/s. There was no significant increase in resistance after use. The addition of the filter to the breathing circuit caused statistically significant decreases in forced expiratory volume in 1 s (FEV1) (0.044 +/- 0.08 L, p = 0.014) and peak expiratory flow rate (PEFR) (0.47 +/- 0.073 L/s, p = 0.004). The filter did not affect other indices of lung function. CONCLUSION: The filter caused a statistically significant reduction in FEV1 and PEFR; however, this difference was believed not to affect the clinical utility of routine lung function testing.

Adult↗
PubMed1989

The stilette sign: the appearance of dilated bile ducts in the fatty liver.

The appearances of hepatic steatosis and of dilated intrahepatic bile ducts occurring independently are well described. When both conditions occur simultaneously a major sign of biliary obstruction, a double lumen with echogenic walls (the double-barrelled shotgun sign), is modified by the abnormally echogenic liver. The combined appearance is of a tubular structure with no echogenic interface with the liver, containing an echogenic structure at its centre representing echoes from the adjacent bile duct and portal vein walls. We have named this appearance the 'stilette' sign because of its resemblance to a fine needle within a tube. Its importance lies in the fact that it makes dilated intrahepatic bile ducts difficult to recognise by ultrasound.

Adult↗
PubMed1989

xylE functions as an efficient reporter gene in Streptomyces spp.: use for the study of galP1, a catabolite-controlled promoter.

We describe the development of a convenient and sensitive reporter gene system for Streptomyces spp. based on the use of a promoterless copy of the xylE gene of Pseudomonas putida. The xylE gene product is a catechol dioxygenase, which converts the colorless substrate catechol to an intensely yellow hydroxymuconic semialdehyde. A promoterless copy of xylE was placed under the transcriptional control of galP1, a glucose-repressed and galactose-induced promoter from Streptomyces lividans, and its expression was examined in bacterial colonies on agar plates or in liquid cultures grown in the presence of glucose or galactose as the sole carbon source. On plates, colonies of bacteria grown on galactose turned bright yellow within a few minutes of being sprayed with a solution of catechol, whereas colonies on glucose-containing plates remained white or only slightly colored, even after extensive incubation. Activity of galP1-xylE fusions was conveniently measured in crude cell extracts with a simple colorimetric assay and was shown to faithfully reflect intracellular RNA levels, as determined by quantitative dot blots. Moreover, differences in expression levels of xylE fusions driven by mutant galP1 promoters were readily apparent in color reactions on plates. The properties of xylE as a reporter gene thus make it suitable not only for quantitatively monitoring expression of regulated promoters in Streptomyces spp. but also for recovering mutations that alter the expression levels of promoters of interest.

Base Sequence↗
PubMed1988

Antibiotic therapy of osteomyelitis in outpatients.

The therapy of osteomyelitis utilizing 481 courses of intravenous antibiotics in outpatients was analyzed to identify the types of bone infection most frequently treated by this form of therapy. The efficacy of this form of treatment is also discussed.

Adult↗
PubMed1986

Contrast media in double-contrast arthrography of the knee: a comparison of ioxaglate and iothalamate preparations.

Hexabrix (sodium and meglumine ioxaglate) is a satisfactory medium for use in double-contrast knee arthrography. It shows no advantage over the ionic medium, meglumine iothalamate, in the quality of the immediate films, but it produces significantly better coating of the meniscus in delayed films and better results in knees which have an effusion. These advantages are to some extent counteracted by the fact that Hexabrix causes more pain or discomfort after the examination than meglumine iothalamate.

Adolescent↗
PubMed1984

Safety aspects of long-term nitrendipine therapy.

More than 1,700 patients with essential or renal hypertension were treated with nitrendipine; data from 967 of these were included in a data pool, and safety data were evaluated. Treatment duration was between 7 days and 2 years. The most frequent side-effects were headache, flush, oedema, dizziness, and palpitations due to the pharmacodynamic effect of the drug. All other side-effects had an incidence below 2%. Eighty-two of the 967 patients stopped therapy before the end of the trial. In 33 of these patients, this was probably due to the side-effects of nitrendipine. Hematological and clinical chemistry data did not indicate any systemic or organ damage. When nitrendipine was combined with thiazides, a lowering of plasma potassium levels could be found, which, however, did not necessitate any therapy.

Calcium Channel Blockers↗
PubMed1975

Space age dentistry.

Explore the source record for details and available documents.

Preventive Dentistry↗
PubMedDate not supplied

The impact of personal and situational variables on career patterns among nurses from three types of educational programs.

Relationships between educational preparation and employment choices were investigated in a study of the career paths of nursing graduates from three types of educational programs: a community college diploma program, a generic baccalaureate program, and a postdiploma baccalaureate program. Selected personal and work-related correlates of career paths for the three groups also were explored. All available graduates for the years 1984 to 1990 from the three programs (n = 1,544) were sent a self-administered questionnaire. Data were collected concerning demographic variables, employment details, ongoing professional development, and level of satisfaction with nursing. Analysis of the data demonstrated clear variations in the career paths of the three groups of graduates, supporting the belief that the type of educational program does indeed have a steering effect on the subsequent career choices of these nurses.

Adult↗
PubMedDate not supplied

Comparisons of venous and diabetic plantar ulcer shape and area.

That diabetic plantar ulcers are "round-like" and venous ulcers are "irregularly" shaped is well known. However, these notions have not been quantified or substantiated systematically. In this retrospective analysis, geometric parameters--including area (A), perimeter (p), and shape factor (SF)--of 255 venous and 305 plantar ulcers have been determined using length (L) and width (W) in specific calculation models; these calculations then were compared with computer planimetry. Length was the maximum dimension and width was the maximum dimension perpendicular to length. Results show that venous ulcers, when compared with plantar ulcers, have significantly smaller shape factors and smaller W/L ratios. An optimized calculation model (A = KoLW) then was used, in which Ko was adjusted to minimize root-mean-square (rms) error among venous and plantar ulcers. Values of Ko differed for venous (Ko = 0.67) and plantar (Ko = 0.73) ulcers, with no significant overall paired-differences in actual vs. calculated area. Overall, these models correctly identified 91.8% of venous and 95.1% of plantar ulcer areas within 20% of actual areas. If venous ulcer SF was > 0.35, 3% of the ulcers exceeded the 20% error limit; if SF was < or = 0.35, then 56% exceeded the 20% error. If plantar ulcer SF was > 0.65, no ulcers exceeded the 20% error limit; if SF was < or = 0.65, 15% did. These findings provide quantitative data of absolute and comparative ulcer shapes and clarify the impact of shape on area assessment accuracy when estimated by simple length by width measures.

Anthropometry↗