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Biomedical subjects

C I Meeker

Publications and source records attributed to C I Meeker.

4 recordsLinked to original sources

A consensus-based approach to practice parameters.

A practice parameter is any guide to the clinical management of a patient. The specificity of these will vary, as will the purpose for which they are written. The "who," "why," and "how" issues are new and legitimate concerns for the medical profession. Medicolegal issues, cost of care, and quality of care are but three of the "whys" that may be addressed by guidelines. Guidelines may differ in subtle but important ways depending on their purpose and who has been selected to write them. Great emphasis has now been placed on the process of writing guidelines. However, physicians have concerns with the basic concept, including the possible emergence of "cookbook" medicine, the effect of patient variability, and the need to keep guidelines current. Guidelines must be valid and credible to be useful. The consensus-based approach, used by ACOG to achieve these ends, includes a four-tiered system of peer review and recognizes the importance of flexibility in any guidelines for clinical practice.

Clinical Protocols

In vivo and in vitro studies of 15alpha-hydroxyprogesterone in the human placenta.

Studies were conducted to determine the fate of 15alpha-hydroxyprogesterone in human placental tissue. Tritiated 15alpha-hydroxyprogesterone was perfused through normal human placentas in situ at the time of Cesarean section and incubated with a 10,000x g microsomal supernate of the placenta in vitro. In both systems the substrate, but no additional metabolites were identified. These findings indicate that 15alpha-hydroxyprogesterone is not metabolized during its passage in the human term placenta, and suggests that because of its fetal origin clinical measurements of 15alpha-hydroxyprogesterone may provide a valuable index to the status of fetal viability.

Crystallization