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Biomedical subjects

C Houdent

Publications and source records attributed to C Houdent.

44 records · Page 3Linked to original sources
PubMed1976

[Rheumatic manifestations in 80 cases of Crohn's disease].

Out of a series of 80 patients suffering from Crohn's disease, 31 presented rheumatic manifestations. In 16 subjects this took the form of synovitis closely dependent on the enteritic evolution, which developed after the alimentary symptoms, and which worsened as they did and sometimes regressed as they did following medical or surgical treatment. In combination with erythema nodosum, aphtosis, and conjunctivitis, synovitis appears to be the expression of an immune response to the enteritic lesion. Three cases of chronic polyarthitis and 6 cases of asymptomatic sacro-ileitis were also observed, and 6 cases of spondylarthritis of a minor radiological type were observed that evolved independently of the Crohn's disease. Typing according to the HLA system using 26 antigens was carried out in 44 subjects; no difference in phenotype frequency was found between a control group (blood donors) and the group of subjects with Crohn's disease alone; however, the antigen W 17 was found significantly more frequently in those subjects with peripheral arthritis and the antigen W 27 was found more frequently in those with spondylarthritis. These findings suggest, although it is not certain, the existence of genetic susceptibility to rheumatic manifestations in certain sites in patients with Crohn's disease.

Arthritis↗
PubMed1976

[Rheumatic manifestations of Crohn's disease. A national survey].

The authors analyse the results of a national survey, by questionnaire, in which 44 rheumatologists participated: the 102 cases of Crohn's disease discovered are divided as follow - 47 cases of peripheral rheumatism, and 55 cases of axial rheumatism, spondylarthritis and sacro-ileitis. The cases of peripheral rheumatism were closely related to the enteritis: appearing after the first digestive symptoms, they follow closely the development of, and recede with intestinal resection of the lesion; mono, oligo, or polyarticular, they develop in brief episodes, in an immune context and are only one symptom among the others of Crohn's disease. In contrast, preceding or following the first digestive symptoms, pelvispondylitis (34 cases) developed quite independently of the enteritis and was modified neither by medical treatment nor surgical treatment; these cases were characterized by equal distribution between the two sexes, inconstancy of syndesmosis, and frequent peripheral involvement. As regards the cases of sacro-ileitis, whether discovered by chance or because of rachialgia and arthralgia, these appear to be similar to the cases of pelvispondylitis and their appearance is probably conditioned by a polygenic transmission factor different from the HL-A B 27 marker.

Adolescent↗
PubMedDate not supplied

[Hypoglycemia induced by cibenzoline in the elderly].

Hypoglycaemia induced by class IA antiarrhythmic agents has been described. A case of cibenzoline-induced hypoglycaemia with favourable outcome is reported. The patient's age (84 years), increased renal impairment and malnutrition acted as facilitating factors. Blood insulin levels were normal in both absolute and relative values. Therapeutic overdosage in relation to age and renal function has been found in 20 out of 24 cases published or recorded by the French pharmacovigilance system. The mechanism of this hypoglycaemia is uncertain; absolute or relative hyperinsulinism has been detected in only 5 out of 14 controlled cases.

Aged↗
PubMedDate not supplied

[Proceedings: Prolactin adenoma revealed by gemellary? pregnancy after clomiphen therapy. Hypophysectomy during 5 th month of pregnancy (author's transl)].

A 25 year old woman had galactorrhea and secondary amenorrhea since her first pregnancy at 20 years. After several treatments with Clomiphene, menses reappeared for 2 months and she became pregnant. At admission, she was in her 4th pregnancy month and had headaches and bitemporal hemianopsia. Hypophysectomy was performed during 5th pregnancy month. Prolactin adenoma with hemorragic lesions was found. Parturition of normal twins occurred 8th month. Partial hypophyseal recovery took place for the following 2 years, but hyperprolactinemia reappeared too.

Adenoma↗
PubMedDate not supplied

[Thyroid pathology and lymphoproliferative diseases].

Four cases are reported, of an association between a thyroidal illness (1 hypothyroidism, 3 hyperthyroidism) on one hand, and a lymphocytic proliferation and/or monoclonal gammapathy on the other. The following findings: HLA B8 or DrW3 in 3, antithyroid antibodies at a very high level in 2, and thyroid stimulating immunoglobulin in 2 support the conclusion of thyroidal diseases of auto-immune nature. Simultaneous appearance of both thyroidal and hematologic illness favors the hypothesis of a non coincidental association. A direct thyroidal activity of the monoclonal paraprotein has been found only once among the 4 published and our 2 cases in which it has been studied. A more likely link would be a common physiopathology: a functional deficiency of T suppressor lymphocytes allowing the proliferation of a cellular clone producing an abnormal immunoglobulin, would also allow the development of a thyroidal illness when favored by a genetic predisposition.

Aged↗
PubMedDate not supplied

[Plasma growth hormone in obese patients. Comparison of response to arginine and L-dopa (author's transl)].

The present study aimed at testing the hypothesis that l-dopa could obtain a better growth hormone (G.H.) stimulation than metabolic stimuli in obese patients. Arginine (30 g i-v) and l-dopa (1 g per os) were used in 12 obese, non diabetic, female in patients. No significant difference of plasma G.H. peak level (arginine : 11,3 ng/ml +/- 8.6. L-dopa : 9.2 +/- 5.6) appeared between these two types of stimulation

Arginine↗