Biomedical subjects
C Hodgson
Publications and source records attributed to C Hodgson.
Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa.
We report the first evidence of increased levels of the retinoblastoma (Rb) message in a majority of colorectal cancers when compared with normal mucosa. Southern blot analysis showed an increase in Rb gene copy number in at least 28% of colorectal carcinomas relative to normal mucosa. These results plus previous reports of nonrandom chromosome 13 gains in approximately 50% of colorectal cancers suggest that an increase in Rb gene copy number occurs frequently in these tumors. Possible mechanisms pertaining to overexpression of the Rb gene are discussed in relation to its role as a recessive cancer gene.
Psoralen photochemotherapy of psoriasis.
The value of PUVA therapy in selected patients with severe psoriasis has been confirmed. Suppression of the disease was incomplete in those patients whose disease was unstable, with associated seborrhoeic dermatitic features. No consistent change in the proportion of epidermal cells in DNA synthesis could be demonstrated during regression of the psoriasis as a result of PUVA therapy.
Human epidermal stimulants, normal and psoriatic.
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Control of amylase secretion in the rat parotid gland during feeding.
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The action of retinoic acid on psoriatic skin.
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The effect of the activity of psoriasis on the response to autologous ground skin extract.
The effects of autologous extracts of involved and macroscopically uninvolved psoriatic skin on epidermal DNA synthesis have been studied. Previous reports of inhibition of DNA synthesis were confirmed but in a number of patients a stimulant, rather than an inhibitory effect, was observed. The stimulant effect was only present when the disease was in an acute, eruptive phase and was more marked in the involved than in the macroscopically uninvolved skin.