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Biomedical subjects

C Herrmann

Publications and source records attributed to C Herrmann.

At least 55 records · Page 3Linked to original sources
PubMed1986

Pathologic evaluation of thymic hyperplasia in myasthenia gravis and Lambert-Eaton myasthenic syndrome.

Eleven thymectomy specimens from patients with myasthenia gravis or Lambert-Eaton myasthenic syndrome were thoroughly sectioned. The results were compared with the routine surgical pathology reports that were based on a median of four sections. Routine sampling was found to be inadequate because the thymectomy specimens were inhomogeneous--some random sections contained germinal centers while others did not. Thus, on more thorough examination, about half of the specimens should have been diagnosed as showing "follicular hyperplasia" rather than "no diagnostic change" or "involution." This helps explain the conflicting results of previous studies, based when stated on a mean of three sections, in which favorable response to thymectomy in patients with myasthenia gravis was either not correlated with the thymus histologic state or correlated variously with few or numerous germinal centers. Thus, nondiagnostic histologic findings based on only one or two thymus sections should be suspect, and if in doubt a larger number of sections should be examined for accurate pathologic diagnosis.

Adolescent↗
PubMed1985

Syndrome of palatal myoclonus and progressive ataxia: two cases with magnetic resonance imaging.

Two patients are reported with palatal myoclonus, progressive ataxia, and dysarthria, unresponsive to treatment with trihexyphenidyl or L-5-hydroxytryptophan. MRI showed enlargement of the inferior olives in one patient, consistent with the pathology usually associated with palatal myoclonus. The syndrome of progressive ataxia and palatal myoclonus should be distinguished from other ataxias and degenerations that affect the brainstem and cerebellum. Pathology and specificity of site of the lesions are distinctive.

Adult↗
PubMed1985

Myasthenia gravis--current concepts.

An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles. The Director of Conferences is William M. Pardridge, MD, Associate Professor of Medicine. Current findings indicate that autoimmune myasthenia gravis is an acquired immune complex disorder of neuromuscular transmission in voluntary striated muscle. There is a break in immunologic tolerance leading to blocking and degradation of acetylcholine receptors, together with widening of the synaptic cleft associated with partial destruction, simplification and shortening of the postjunctional membrane. Thymic hyperplasia and thymoma may be present. A decremental response to nerve-muscle stimulation, blocking and jitter on single-fiber electromyography and circulating antibodies to acetylcholine receptor are detectable in most patients with generalized weakness. Although the cause of this abnormal immunologic mechanism remains to be discovered, anticholinesterases, corticosteroids, immunosuppressants, plasmapheresis or thymectomy (individually or in combination) provide control and better prognosis in most patients.

Acetylcholine↗
PubMed1984

[Double-blind comparative study of lorazepam and tiapride effects on the memory capacities of subjects over 60 years of age].

The authors' purpose was to confirm their hypotheses based on their prior study of the effect of tiapride and lorazepam on memorizing capacities of patients over sixty years of age. The results of a two weeks, double-blind trial show that tiapride, in addition to its sedative action, produces disinhibition and enhances wakefulness, thereby improving memory performances in the elderly.

Aging↗
PubMed1984

[Anxiolytics and mnemonic ability of the aged subject. Apropos of a double-blind study between tiapride and lorazepam].

Starting from a study of memory performances while prescription in double blind of lorazepam (2 mg/day) versus tiapride (100 mg/day), during ten days, to patients over sixty years of age, the authors try to analyse the links between anxiety, anxiolysis and attention and memory capacities. Results seem to indicate that beyond anxiolysis, these products could have an independent action over memory performances. Statistical trial of results show significantly that performances decrease under lorazepam and increase under tiapride.

Aged↗
PubMed1983

[Comparative study of the effect of lorazepam and tiapride on memorizing capacities of patients over 60 years of age].

Our purpose was to investigate the action on memory disorders of patients over sixty years of age of a well tolerated sedative neuroleptic, tiapride, and of a short-half-life benzodiazepine, lorazepam. Thirty subjects divided into two groups were entered in a three week trial. The product's effect on both anterograde memory and remote memory was assessed by the simple memory test used. Statistical conclusions show that tiapride is very significantly superior to lorazepam in every studied criterion, with disinhibition and stimulation of vigilance. These hypotheses need to be confirmed.

Aged↗
PubMed1983

Thymectomy for myasthenia gravis.

Thymectomy was performed on 249 patients with myasthenia gravis between 1957 and 1981. During a follow-up period that ranged from 2 months to 24 years (mean 7.5 years), the remission rate for the entire group was 51 percent, and an additional 36 percent had improvement (87 percent benefited). In those 51 patients with thymoma, the remission rate was 37 percent, with 68 percent of the patients benefiting from operations. The remaining 198 patients fared better after the operation: 54 percent had remission and a total of 91 percent benefited. The female patients within this group had a 94 percent probability of benefit from operation. We conclude that most patients with myasthenia gravis will benefit from thymectomy, and that the improvement persists over an extended period of time in a high percentage of patients.

Adolescent↗
PubMed1983

[Catamnestic studies on the prognosis of sudden deafness].

The progression of the auditory system after the sudden deafness was investigated in 104 patients, one to eighteen years after the first appearance of their disease. The late development shows in 66% a stationary hearing and in 14% an improvement of the hearing. That means that beside a recurrence (7.7%) a slowly aggravation can be found in 12.3%. Stenocardic trouble and angiocardiopathies are peculiarly often reported by the patients. A reliable relation between sudden deafness and cerebral disturbed circulation could not be found.

Cerebrovascular Disorders↗
PubMed1982

Non-steroidal anti-inflammatories--XII. Mode of action of anti-inflammatory methane sulfonanilides.

The influence of anti-inflammatory methane sulfonanilides on the arachidonic acid metabolism in ram seminal vesicle homogenate depends on the pK3 of the individual substance: more acidic compounds suppress, less acidic compounds stimulate PG synthesis and enhance the PGH2/PGG2 ratio. As oxygen radicals are liberated during the conversion of PGG2 to PGH2 it is suggested that the less acidic methane sulfonanilides are scavengers of the (pro-inflammatory) oxygen radicals.

Animals↗
PubMed1982

Acetylcholine receptor antibody titer and HLA-B8 antigen in myasthenia gravis.

In 82 white patients with myasthenia gravis, a high serum human acetylcholine receptor (AChR) antibody titer was related to the presence of the HLA-B8 antigen and increasing severity of the disease and not to age at onset, sex, presence of thymoma, or mode of treatment. Among patients without thymomas a high antibody titer was also associated with HLA-B8, particularly in those patients whose age at onset was less than 35 years. Thymectomy was associated with a lower median antibody titer when compared in two groups of HLA-B8-positive patients without thymoma who were similar for all other factors. Patients with thymomas who had received corticosteroids had a lower median titer than those who had not received steroids. This study supports the possibility that immune-response genes near the HLA-B8 segment of the major histocompatibility complex participate in the regulation of the humoral response to autoantigens, such as AChR protein.

Adult↗
PubMed1981

[IgM antibodies against cytomegalovirus in pregnancy and incidence of intrauterine infections in pregnant women with positive IgM antibody reaction (author's transl)].

In 47 of 620 pregnant women (7.6%) examined during the first, second and third trimester, it was possible to identify IgM, antibodies against late antigen (LA) of the cytomegalovirus during one or several examinations. 6 of 37 examined children of mothers with positive IgM antibody reaction were found to have intrauterine infection, although there had been no clinical signs of an infection at the time of delivery. All 6 children with intrauterine infection were from 32 mothers (18.8%) with IgM antibodies during the first trimesters. The IgM antibodies of the mothers with children having intrauterine infection did not differ fundamentally from the IgM antibody levels of the mothers with non-infected children with regard to titration value and persistency.

Adolescent↗