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Biomedical subjects

C Henkel

Publications and source records attributed to C Henkel.

At least 19 recordsLinked to original sources
PubMed2005

Optical microscopy via spectral modifications of a nanoantenna.

The existing optical microscopes form an image by collecting photons emitted from an object. Here we report on the experimental realization of microscopy without the need for direct optical communication with the sample. To achieve this, we have scanned a single gold nanoparticle acting as a nanoantenna in the near field of a sample and have studied the modification of its intrinsic radiative properties by monitoring its plasmon spectrum.

Journal Article↗
PubMed2005

Identification of fibrosis-relevant proteins using DIGE (difference in gel electrophoresis) in different models of hepatic fibrosis.

Proteomics became a more and more important technique for the large-scale analysis of proteins during the last years. Two-dimensional (2D) electrophoresis as a major tool of proteomics is a powerful method to compare two different biological stages (e. g. healthy and diseased tissue) and to find differences in their protein pattern. One major problem in proteomics is the gel to gel variation of two-dimensional gel electrophoresis, which could cause artefacts in the detection of expression differences. The "difference in gel electrophoresis" (DIGE) technique allows the separation of two proteomes in the same gel. The protein pools were labelled with different fluorescent dyes and equal amounts of protein were separated in the same gel. Another advantage of DIGE is the possibility to separate an internal standard labelled with a third dye in the same gel to allow quantitative expression analysis. We compared proteomes of three different fibrosis models with the appropriate control (tissue inhibitor of metalloproteinases-1 (TIMP-1) overexpressing HepG2 cells in comparison to a HepG2 control, freshly isolated HSC in comparison to activated HSC and healthy mouse liver in comparison to fibrotic mouse liver). Among the differentially expressed proteins several were already found to be relevant for fibrosis but we also detected some proteins like the selenium binding protein 2 which might be relevant for hepatic fibrosis.

Animals↗
PubMed2000

Hubble Space Telescope and Very Large Array Observations of the H2O Gigamaser Galaxy TXS 2226-184.

We present Hubble Space Telescope/Wide-Field and Planetary Camera 2 images in Halpha + [N ii] lambdalambda6548, 6583 lines and continuum radiation and a VLA map at 8 GHz of the H2O gigamaser galaxy TXS 2226-184. This galaxy has the most luminous H2O maser emission known to date. Our red continuum images reveal a highly elongated galaxy with a dust lane crossing the nucleus. The surface brightness profile is best fitted by a bulge plus exponential disk model, favoring classification as a highly inclined spiral galaxy (i=70&j0;). The color map confirms that the dust lane is aligned with the galaxy major axis and is crossing the putative nucleus. The Halpha + [N ii] map exhibits a gaseous, jetlike structure perpendicular to the nuclear dust lane and the galaxy major axis. The radio map shows compact, steep spectrum emission that is elongated in the same direction as the Halpha + [N ii] emission. By analogy with Seyfert galaxies, we therefore suspect that this alignment reflects an interaction between the radio jet and the interstellar medium. The axes of the nuclear dust disk, the radio emission, and the optical line emission apparently define the axis of the active galactic nucleus. The observations suggest that in this galaxy the nuclear accretion disk, obscuring torus, and large-scale molecular gas layer are roughly coplanar. Our classification of the host galaxy strengthens the trend for megamasers to be found preferentially in highly inclined spiral galaxies.

Journal Article↗
PubMed1995

A water-vapour giga-maser in the active galaxy TXFS2226-184.

Active galactic nuclei are thought to be powered by gas falling into a massive black hole; the different types of active galaxy may arise because we view them through a thick torus of molecular gas at varying angles of inclination. One way to determine whether the black hole is surrounded by a torus, which would obscure the accretion disk around the black hole along certain lines of sight, is to search for water masers, as these exist only in regions with plentiful molecular gas. Since the first detection of an extra-galactic water maser in 1979, they have come to be associated primarily with active galaxies, and have even been used to probe the mass of the central engine. Here we report the detection of a water giga-maser in the radio galaxy TXFS2226-184. The strength of the emission supports a recently proposed theory of maser pumping that allows for even more powerful masers, which might be detectable at cosmological distances. Water masers may accordingly provide a way to determine distances to galaxies outside the usual distance ladder, providing an independent calibration of the Hubble constant.

Astronomical Phenomena↗
PubMed1975

[Diagnostic and therapeutic aspects of subarachnoidal hemorrhage from the viewpoint of emergency medicine].

The subarchnoidal haemorrhage is an acute disease which has a high lethality and, therefore, in every case presents an indication for admission into an intensive-therapeutic department. It often occurs in younger age groups and appears more frequently than is assumed in general. Despite impressive clinical symptoms (suddenly beginning stabbing headache, vomiting and disturbances of consciousness of various degree of severity) the picture of the disease is not exactly diagnosed almost in every case. From 1970 to 1974 we treated 105 patients with subarachnoidal haemorrhages. In this paper is referred to the most important clinical and paraclinical parameters. Diagnostic and therapeutic possibilities are discussed.

Adolescent↗
PubMed1975

[Poisoning with nitrosifying gas].

Nitrosifying gases are nitrogen-oxygen mixtures which are used in many branches of industry or which develop as a sideproduct. They are toxic already in a relatively slight concentration. It is reported on 12 patients who on account of an accident in a Berlin metal factory fell ill with an acute intoxication by nitrosifying gas. Symptoms, clinical and paraclinical findings are compiled and compared with the cases described in literature. Therapeutic orders are discussed.

Accidents, Occupational↗