Search PubMed⌕ Search

Biomedical subjects

C Hengy

Publications and source records attributed to C Hengy.

32 records · Page 2Linked to original sources
PubMed1990

[Uncomplicated malaria attack in an area with high chloroquine resistance. 2. Evaluation of first-choice therapeutic scheme].

The authors evaluate the comparative efficiency of chloroquine and amodiaquine (35 mg/kg during 3 days) for uncomplicated malaria treatment in an area with high chemoresistance level. 236 patients with malaria were examined and treated. 38% of them previously used antimalarials. The increase dosage in comparison with the WHO recommendations (25 mg/kg), lead to no advantages for chloroquine treatment (50% failure), in contrast with amodiaquine (4% failure). Therefore amodiaquine might be preferred in the health field unit for uncomplicated malaria.

Amodiaquine↗
PubMed1990

[Uncomplicated malaria attack in an area with high resistance to chloroquine. 3. The use of second-choice oral drug treatment].

This study appreciated the efficiency of uncomplicated malaria second line treatment (P. falciparum) in an area with high level of chemoresistance. No therapeutic failure was found with sulfadoxine-pyrimethamine (Fansidar), and mefloquine-sulfadoxine-pyrimethamine (Fansimef), in contrast with a rate of 8% with quinine. The authors discuss the place of these therapeutic, in the treatment of malaria.

Adolescent↗
PubMed1989

[Surveillance of Plasmodium falciparum drug sensitivity in Yaounde and its surroundings (Cameroon). In vivo and in vitro study].

Among 172 strains collected in Yaoundé 60% are chloroquine-resistant, 37% are amodiaquine-resistant, instead of quinine and mefloquine which are completely efficient. Among 30 strains collected at a rural health center (where self treatment decreases), 27% are chloroquine-resistant. New therapeutic schemes for first and second line treatment in endemic areas must be evaluated.

Adolescent↗
PubMed1984

[In vitro virucidal activity of antiseptics and disinfectants. II. Simple dilution technic].

The simple dilution technique is based on termination of the tested agent's antiviral activity by sudden cold dilution (D). It can be used only if D less than or equal to 10(3) but is the most simple method. We used this technique to study ATS and demonstrate the strong virucidal activity of glutaraldehyde, inefficiency of chlorhexidine digluconate and questionable activity of povidone-iodine and noxythiolin.

Anti-Infective Agents, Local↗
PubMed1984

[In vitro virucidal activity of antiseptics and disinfectants. III. Dilution-ultrafiltration-reconcentration technic].

The method for in vitro investigation of virucidal activity of antiseptics (ATS) of disinfectants (DSF) using dilution-ultrafiltration-reconcentration includes two phases following contact of the virus with ATS or DSF: termination of antiviral activity by sudden cold dilution, and one or more filtrations on an immersible molecule separator designed to bring the tested agent's concentration below the cytotoxic level and to reconcentrate the treated viral suspension. Advantages of this technique are the following: precision of time of contact between virus and ATS or DSF, reconcentration of the viral suspension which partly offsets the termination dilution, relative simplicity, and study of true virucidal activity. Drawbacks are: inappropriateness for some agents such as povidone-iodine, and, in some instances, unreliability of immersible separators. Apart for those obtained with povidone-iodine, results are comparable to those yielded by simple dilution or gel filtration, particularly for glutaraldehyde, chlorhexidine and noxythiolin.

Anti-Infective Agents, Local↗
PubMedDate not supplied

[Health care accessibility and adequacy of health care system in the Sanaga basin (Central Cameroon)].

The authors report on the results of a Survey Carried out in four areas in Center Cameroon. Health gets a major position within the concerns of the population to protect it, they prefer the classical and official system of health Care rather than the primary Health care System. Self-medication is also a preferred solution. In the rural milieu, they often pay a visit to a traditional practitioner. When they have to take a decision, geographical situation and money problem play both a major role.

Cameroon↗
PubMedDate not supplied

[Epidemiology of endemic leprosy in the People's Republic of the Congo. Risk factors and markers].

A national prevalence survey of leprosy was made in june 1989 in Popular Republic of Congo: authors report results. The prevalence rate is 5.8% +/- 2.6% among people more than 15 years of age, and 10.5% of all forms are multibacillary. All patients are under DDS monotherapy. One overwhelming risk factor is leprosy antecedents in the family history; active case-finding and surveillance of contacts are recommended.

Adolescent↗
PubMedDate not supplied

[Malaria and surgery: which prophylaxis?].

The authors report on a study carried out at the Centre Hospitalier universitaire (University Hospital) of Yaounde (Cameroon). Such a study aimed at to check interest of systematic malaria chemoprophylaxis during the peri-operative phase in general surgery. 61 patients were divided in two groups by random allocation with and without quinine chemoprophylaxis. All of them were monitored clinically and parasitologically during the peri-operative phase. Results show that in both groups, only patients already positive before surgical intervention presented clinical malaria signs, biologically confirmed; malaria attack was more frequent and more severe in the group without quinine. No malaria attack was observed in patients of both groups in which thick smear was negative in pre-operative phase. The authors suggest that any patient during the pre-operative phase, be tested to find out Plasmodium falciparum. If the test is positive, so chemoprophylaxis with quinine be prescribed. But such a medication is valuable only in urban endemic zone.

Adult↗
PubMedDate not supplied

[Evaluation of the efficacy of amino 4-quinolones in a chemoresistant zone. Proposals for new therapeutic schemes].

The authors compare the respective therapeutic efficiency of chloroquine and amodiaquine in the treatment of Plasmodium falciparum malaria fever in urban dispensaries. Chloroquine has a constant rate of efficiency, whatever dosage and duration of treatment be and should be saved for home presumptive treatment of malaria fever. Amodiaquine at a dose of 35 mg/kg in 3 days leads to a noticeable clinical success (96.5 p.c.). It should be selected as drug of first to treat any malaria fever case biologically confirmed, in urban dispensaries.

Amodiaquine↗
PubMedDate not supplied

[Evaluation of Plasmodium falciparum susceptibility to chloroquine and amodiaquine using a simplified, in vivo, 7-day test in southern Cameroon].

Plasmodium falciparum susceptibility to chloroquine and amodiaquine at a posology of 25 mg/kg per os in 3 days was evaluated in the pupils of 6 primary schools of South-West Cameroon during the first semester 1989. Parasitic index was 75%. Plasmodium falciparum was present in 96% of the infections 24% of the 357 children treated with chloroquine were carriers of trophozoites at D3 and 17% at D7. Complete resistance, at level R III, was observed in 4% of the children. By the 55 children treated with amodiaquine, 13% and 10% were carriers of few trophozoites at D3 and D7. The significance of these results is discussed.

Adolescent↗
PubMedDate not supplied

[Epidemiologic aspects of malaria in Gabon].

The authors report the results of 3 sample surveys carried out in Libreville, Ngounié and Haut-Ogooué Provinces to evaluate the main malarial indexes among 0 to 15 years old children in Gabon. These investigations would suggest that malaria is mesoendemic in the three areas. The systematic presumptive antimarial treatment of fever attacks is widely used in Libreville but not so frequent in rural areas.

Adolescent↗
PubMedDate not supplied

[Strategies for prevention of human malaria. Some proposals for central Africa].

The occurrence and the extension of chemoresistance of Plasmodium falciparum to antimalaria drugs in Central Africa set to think about new strategies of prevention. Beside chemoprophylaxis limited to certain groups at particular risks, the authors suggest to rehabilitate vector control and particularly to promote the systematized use of bed-nets impregnated with residual insecticides. Prevention of lethality has to continue to use, in first instance, quinine and amino-4-quinoleins, under condition that an efficient national organization be set up to monitor the chemosensibility of plasmodial strains toward different antimalarial drugs.

Africa, Central↗
PubMedDate not supplied

[Filarial meningoencephalitis: discussion of a case].

Loiasis treatment by diethylcarbamazine (DEC) may be complicated by a meningoencephalitis that is often fatal. Following one case, four others have been reviewed in the literature and the therapeutic approach in resuscitation departments discussed. Until the discovery of other less-dangerous microfilaricidal or macrofilaricidal drugs, we raise the question of the opportunity to treat loiasis by DEC, while many authors consider it as a simple nuisance.

Adult↗