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Biomedical subjects

C Heinz

Publications and source records attributed to C Heinz.

At least 37 records · Page 2Linked to original sources
PubMed1986

Swiss adjuvant trial (OSAKO 06/74) with chlorambucil, methotrexate, and 5-fluorouracil plus BCG in node-negative breast cancer patients: nine-year results.

Between 1974 and 1977, a total of 254 patients with stages T1-3a, N0-1, and M0 operable breast cancer (node negative and node positive, stratified) were randomized to either modified radical mastectomy alone or the same surgery and adjuvant chlorambucil, methotrexate, 5-fluorouracil (LMF) plus BCG. After a median follow-up of 9 years (January 1985), we concluded that LMF plus BCG significantly increased relapse-free survival (RFS) in 240 fully evaluated patients, especially postmenopausal women. This gain in RFS ceased to transform into a gain in overall survival (OAS) after 7 years of median follow-up for the whole patient group. In the 122 node-negative patients studied, LMF plus BCG produced a marked increase in RFS up to the fifth year and in OAS up to 8 years after initial surgery, thus prolonging significantly the median disease-free interval compared with surgical control patients. This trend favoring LMF plus BCG-treated patients continues. Although median time to first relapse and to generalized disease were increased in relapsing patients by LMF plus BCG, the subsequent intervals from local relapse to distant disease and from distant metastases to death were equal for both treatment regimens. Subjective and objective acute toxicity from LMF plus BCG was mild. At 9 years of median follow-up, fewer second tumors were noted in the node-negative group receiving LMF plus BCG than in surgical controls.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1982

Adjuvant chemoimmunotherapy with LMF plus BCG in node-negative and node-positive breast cancer - intermediate report at 4 years.

A randomized surgical adjuvant trial in 242 evaluable patients with T1-3a, N0-1, and M0 breast cancer was initiated 4 years ago. The well-tolerated, oral combination chemotherapy with six cycles of Leukeran plus methotrexate plus fluorouracil (LMF) plus repeated BCG skin scarifications was used. After 4 years, the following results were seen: (1) significant increase of relapse-free (RFS) and also overall survival (S) in both pre- and postmenopausal node-negative patients versus surgical controls (RFS 91.1 vs. 701%, P = 0.003; S 96 vs. 88%, P = 0.03); (2) no significant increase of RFS or S in pre- and postmenopausal node-positive patients versus surgical controls (RFS 50.1 versus 44%, P = 0.49; S 70 versus 68 %, P = 0.9, respectively); (3) Patients receiving greater than 90% of the planned LMF dose showed significantly better survival after 4 years; and (4) Nonrandomized comparison with concurrent Swiss adjuvant studies with LMF alone indicate no beneficial or harmful effect of BCG skin scarifications in addition to the six-cycle LMF.

Breast Neoplasms↗
PubMed1981

[Carpal tunnel syndrome in infants].

We have observed and operated on 5 children at the age of 15 months to 6 years for carpal tunnel syndrome. 4 children, all belonging to the same family had bilateral median nerve compression syndrome. These 4 children also suffered from bilateral tenosynovitis, and a mild form of mucopoolysaccharidosis (M. Scheie) was diagnosed. The symptoms in all 5 children were uncharacteristic and initially difficult to associate with nerve compression at first. Numbness and dysaesthesia in the thumb, index and middle finger, the most frequent signs in adult patients, were missing. In these children, the observation of general manual clumsiness, unusual patterns of grasping, sudden change in playing habits with avoidance of manual activity led to the suspicion of a median nerve compression syndrome. In all children decompression of the median nerve resulted in normalization or marked improvement of hand function.

Carpal Tunnel Syndrome↗
PubMed1978

[Percutaneous transluminal recanalization in a patient with arterial occlusive disease and multiple injuries (author's transl)].

A case of a 66 year old patient with multiple injuries is reported. A combination of conventional trauma treatment and percutaneous transluminal angioplasty (PTR) of a segmented superficial femoral artery occlusion prevented leg amputation. When the patient died 8 weeks later from trauma sequelae the successful recanalization was demonstrated in histopathology investigation. It is concluded that PTR is an ideal accessory to the present therapeutic spectrum in vascular surgery.

Accidents, Traffic↗
PubMed1976

[Late results after surgical treatment of carpal tunnel syndrome. A clinical follow-up study of 60 cases].

In a follow-up study 60 hands of 49 patients were examined 1-12 years after operation for carpal tunnel syndrome. The syndrome was diagnosied in the majority of cases on clinical examination only. Paresthesia, hypesthesia or anesthesia in the 3 1/2 radial fingers of the hand are typical signs. Some patients complained of severe pain irradiating towards the elbow and shoulder. The method of surgical treatment is described in detail. Of the 49 patients only 2 were dissatisfied with the result. Both patients suffered from stenosing arteriosclerotic disease of the peripheral arteries of the hand and their pain and paresthesia were relieved by thoracic sympahtectomy. 58% of patients had complete relief from from symptoms while the remaining cases had a significant reduction of symptoms and were satisfied with the result of surgical treatment. The results were better in those patients who were operated on soon after the onset of symptoms. From the results of this study it is clear that surgical treatment of carpal tunnel syndrome provides good results and that surgical treatment should be recommended without delay if conservative treatment is unsuccessful.

Adult↗
PubMed1975

[The hypermobile skin- and soft-tissue tube in thumb reconstruction].

Reconstruction of an amputated thumb using a bone graft covered by a tubed skin pedicle gives good results if sufficient vascular supply and sensory innervation is transferred to the reconstructed thumb by a neruovascular island pedicle flap and if the skin and soft tissue tube is fixed well enough to the bone graft. Hypermobility of the skin prevents firm and accurate gripping. Fixation of the skin tube to the bone is best achieved at the time of neurovascular pedicle transfer. At the margin of the skin incision a strip of dermis is left and screwed to the periosteum. This method has been described by CHASE. If hypermobility of the skin persists after the neurovascular pedicle has been transferred the skin can be fixed to the bone using strips of fascia, dermis or lyodura. The operative technique of this procedure is described in detail.

Amputation, Traumatic↗