Cytoimmunologic monitoring after heart transplantation.
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Follow-Up Studies↗
Biomedical subjects
C Hammer
Publications and source records attributed to C Hammer.
[Fundamental concepts in the implementation of the spectroscopic magnetic resonance for the determination of the biological quality of human cartilage transplants].
Cartilage grafts are often used in reconstructive surgery for compensating loss or defect in tissues. Future progress in this field are related to the resolution of some problems concerning the preservation in our tissue-banks. Several time-expensive biochemical, histological and autoradiographic methods have been employed in the past to describe the metabolic properties and pathological changes of preserved and transplanted cartilage grafts. In this article we show that magnetic resonance spectroscopy offers the possibility to recognize metabolic changes in cartilage tissues as a consequence of storage conditions: anaerobic metabolism (lactacte) and lysis of collagenic structures of the matrix. In this way objective parameters assessing the biologic quality of grafts can be obtained without any destructive impact on the specimen.
Cadaver↗
[Comparative study of the effect of different chemical procedures on the antigenicity of allogenic transplants of the human trachea].
Replacement of long tracheal segments poses some unsolved problems, specially the undisponibility of an adequated substitution material. This study deals with some of the immunological aspects of the transplantation and preservation of human tracheal grafts. Since immunological rejection occurs in the first place as a consequence of incompatibility for class II antigens (HLA-DR, -DP and -DQ), their presence and distribution was studied using monoclonal antibodies and the immunoperoxidase method. Class II expressing cells were recognized in the mucosa and the mixed glandular tissue. Furthermore we investigated the influence of different preservation methods on the antigenicity of tracheal allografts. The results showed a total destruction of these antigens. We can conclude that chemically preserved human tracheal allografts are immunologically suitable for reconstructive surgery of the trachea.
Cialit↗