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Biomedical subjects

C Haas

Publications and source records attributed to C Haas.

At least 163 records · Page 9Linked to original sources
PubMed1981

Phase I evaluation of ICRF-187 (NSC-169780) in patients with advanced malignancy.

ICRF-187 (NSC-169780), the (+) enantiomer of the racemic antineoplastic agent ICRF-159 (NSc-129943), was administered intravenously for five days every three weeks to 18 patients in a phase I study. Leukopenia was the dose-limiting toxicity. Mild reversible elevations in SGOT and bilirubin were common. Other toxicities were mild and infrequent. Recommended doses of ICRF-187 for phase II studies are 800 mg/m2 for heavily pretreated patients and 1250 mg/m2 for patients with little or no prior therapy. A daily five day intravenous schedule should be used. Other potential clinical uses of ICRF-187 are discussed.

Adult↗
PubMed1981

[Periarteritis nodosa and carcinoma of the colon. A case report (author's transl)].

It is extremely rare to observe the simultaneous progression of periarteritis nodosa (PAN) and cancer. A patient was found to have histologically confirmed PAN shortly after excision of an adenocarcinoma of the descending colon. High levels of carcino-embryonic and then HbS antigens were discovered in the serum. A favorable medium-term result was obtained after corticoids and multiple cytotoxic chemotherapy. If one accepts that the typical vascular lesions of PAN are due to an antigen-antibody conflict producing circulating immune complexes, it is reasonable to suggest the hypothesis that many antigens could be involved in the production of immune complexes of this type. Many authors accept that HbS antigen is implicated, certain tumoral antigens may also play an analagous role.

Adenocarcinoma↗
PubMed1981

[Allergic granulomatosis and angiitis (Churg-Strauss syndrome) or bronchial asthma with periarteritis nodosa (author's transl)].

The coexistence of hypereosinophilic asthma and periarteritis nodosa, though rare, has been recognised for a long time (Wilson and Alexander, 1945). Based on clinical (asthma, hypereosinophilia) and histological (extravascular granulomas) criteria, Churg and Strauss, in 1951, described a single entity which they considered to be distinct from PAN, and which they called allergic and granulomatous angiitis. The authors describe three such cases, compare their findings with those in the published literature, and discuss the classification of Churg and Strauss' syndrome in relation to PAN. Apart from the asthma and hypereosinophilia, symptomatology is comparable with that of PAN, and histological examination demonstrates very similar vascular lesions in both affections. Extravascular granulomas do not appear to be truly specific. It would seem that there is a lack of essential features that could separate PAN from Churg and Strauss' syndrome, the preexistence of an asthmatic state perhaps simply modifying the PAN disorder in certain particular ways.

Adult↗
PubMed1981

Cis-diamminedichloride platinum(II), an effective agent in the treatment of epidermoid carcinoma of the esophagus. A preliminary report of an ongoing Southwest Oncology Group study.

The southwest oncology group tested cis-platinum, given in 28-day courses of 50 mg/m2 twice, a week apart, in patients with epidermoid carcinoma of the esophagus. Currently 19 patients entered on the study are evaluable for response (15 fully evaluable). Of these, two attained complete disappearance of tumor and four had partial responses. Of the remainder, two had stable disease lasting in excess of 90 days. Hematologic toxicity has been minimal except that three patients required multiple blood transfusions for anemia not due to blood loss. Of 21 patients currently evaluable for renal toxicity, nine had mild, and three had moderate azotemia. These results suggest that, unlike what has been believed in the past, squamous cell carcinoma of the esophagus is not a chemotherapy-resistant tumor. Further evaluation of cis-platinum alone and in combination with radiotherapy and surgery are in progress.

Carcinoma, Squamous Cell↗
PubMed1980

[Pulmonary actinomycosis grafted on former tuberculous lesions. Report of one case (author's transl)].

The occurrence of actinomycosis localized in former tuberculosis cavities in a 39-year-old woman is reported. Exeresis of the lesions allowed the discovery of Actinomyces israelii in one of the cavities which no longer communicated with the bronchial tree. In contrast to diffuse actinomycosis found in immuno-depressed patients, this form of the disease was localized in a woman in good health. A decrease of pulmonary defense mechanisms could be involved locally. The infrequency of a tuberculosis-actinomycosis sequence, contrary to aspergilloma, is perhaps due to the anaerobic metabolism of the Actinomyces.

Actinomyces↗
PubMed1979

5 FU infusion with mitomycin-C vs. 5 FU infusion with methyl-CCNU in the treatment of advanced upper gastrointestinal cancer: a Southwest Oncology Group Study.

A randomized trial was conducted by the Southwest Oncology Group (SWOG) in advanced carcinoma of the stomach and pancreas. Patients were assigned to receive monthly 5-fluorouracil 96-hour continuous infusions with either bolus mitomycin-C or oral methyl-CCNU. Mitomycin-C and methyl-CCNU were administered every eight weeks. The 5 FU-mitomycin combination produced a 14% and 22% response rate in disseminated stomach and pancreatic carcinoma, respectively. The combination of infusion 5 FU and methyl-CCNU achieved responses in 9% and 5% of stomach and pancreatic tumors, respectively. There was no significant difference in survival between limbs for either tumor. Median survival in gastric carcinoma on the 5 FU-mitomycin regimen was 25 weeks vs. 18 weeks on the 5 FU-METHYL-CCNU arm. In pancreatic carcinoma median survival on the mitomycin limb was 19 weeks as compared to 17 weeks on the methyl-CCNU program. Leukopenia was greater for the first course on the mitomycin limb. Regression analysis demonstrated that performance status was the most important pretreatment characteristic for predicting survival in both tumors. Neither 5 FU infusion combination appears to significantly alter the dismal prognosis of advanced upper gastrointestinal neoplasms.

Antineoplastic Agents↗
PubMed1979

[Primary gastric plasmacytoma with IgG dysgammaglobulinemia and macrocytic anemia (author's transl)].

The authors report a case of a woman aged 76 years with a single plasmocytoma of the stomach secreting large quantities of a paraprotein of the IgG type with Kappa light chains. A macrocytic anemia due to deficiency of gastric intrinsic factor was also present. This pathological association is extremely rare. About sixty cases of gastric plasmocytoma are been reported in the published literature and their principal characteristics are briefly outlined.

Aged↗
PubMed1978

Pancreatic cancer treated with carmustine, fluorouracil, and spironolactone: a randomized study.

A prospective randomized trial between two drug regimens in 38 patients with advanced pancreatic carcinoma was performed. The two-drug regimen consisted of carmustine and fluorouracil. The survival rate and response to these two drugs was compared to a three-drug regimen consisting of these same two drugs plus spironolactone. Objective partial responses were rare in both groups, being 3/18 in the two-drug group and 2/20 in the three-drug group. Life table analysis in previously untreated patients from time of treatment shows longer survival for the three-drug group, but this difference was not statistically significant.

Adult↗
PubMed1977

[Hemodynamic aspect of post ECC cardiac failures. Study of 193 cases].

The aim of this study is to define the hemodynamic characteristics of this "clinical model" of acute cardiac failure observed after cardiac surgery carried out under extra-corporeal circulation, which constitutes the essential cause of "post-operative low cardiac output syndrome". The 193 patients in this study make up a representative sample of patients operated, treated and studied according to a homogeneous methodology for a period of 1 year. The clinical analysis of the post-operative circulatory condition, after exclusion of non cardiogenic syndromes, led to grouping the cases into 5 classes of circulatory change of increasing severity, each corresponding to a specific "therapeutic necessity". The hemodynamic results (intra-vascular pressures, oxymetry, cardiac output by "Cardio-Green" dilution method) are given for each of the five classes, thus defining the "hemodynamic profile" and the statistical reliability of the main objective parameters. This gives proof of the therapeutic indications for the main therapeutic procedures actually known, for which we prevent the hemodynamic effects noted for each of them. Thus, three "degrees of cardiac failure" are found: less severe (classes I and II) call for simple metabolic equilibration and possibly diuretics: the systolic work is above 160 gm/m2. Decompensated circulatory failure (classes III and IV) corresponds to a more important reduction in systolic work (9) 15 gm/m2, i.e. between 20 et 40 p. 100 of the basal value), and call for sympatho-mimetic cardiotonic agents: isoprenaline and/or dopamine. Below this value, in spite of medical treatment, the hemodynamic situation can still be sometimes reversible under circulatory assistance (diastolic counter pressure by means of an aortic balloon). Confronted with the clinical picture, the hemodynamic study enables the quantification of the circulatory change, and specification of the cardiogenic part and thus especially helps the carrying out of the treatment.

Adolescent↗
PubMed1977

[Transrectal prostate puncture biopsy in ambulatory care].

The transrectal puncture biopsy is an effective method in the histological clarification of suspicious palpation findings of the prostate. The puncture is technically simple, is to be performed in an outpatient department, can be repeated if necessary and is only of little stress for the patient. Preparation of the intestine or anaesthesia are not necessary. No severe complications were observed. The only little traumatized tissue cylinders obtained by means of the TRU-cut-needle allow the pathologist as a rule an evident assertion.

Aged↗