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Biomedical subjects

C H Wulff

Publications and source records attributed to C H Wulff.

28 records · Page 2Linked to original sources

Computed tomographic findings of early subacute sclerosing panencephalitis.

Computed tomography of the brain (CT) was carried out at the early stages of subacute sclerosing panencephalitis (SSPE) in three children. The lateral ventricles were very small and the hemispheric sulci and interhemispheric fissures were not visible in all three patients in contrast to severe atrophy found at a later stage in one patient. The early CT abnormalities were revealed at the same time as the titres of measles antibodies in blood and cerebrospinal fluid were elevated, and the characteristic periodic complexes in the electroencephalogram established the diagnosis of SSPE. The CT changes indicating brain swelling reflect the reactive changes of this slow virus infection.

Child↗

Painful legs and moving toes. A report of 3 cases with neurophysiological studies.

3 patients with the condition of "painful legs and moving toes" are reported. The etiology was unknown in 2 of them, but in 1 patient the symptoms were temporarily relieved by surgery for a lumbar herniated disc. The movements restarted 6 months after surgery. EMG studies showed near rhythmical muscle action potentials in the involved muscles of the foot at rates of 3.0, 2.5 and 0.5 cps respectively with a maintained reciprocal innervation. These spontaneous movements could only be suppressed for seconds. The EEG, nerve conduction studies and somatosensory evoked potentials were normal.

Adult↗

Sequential EEG findings and symptoms in partial seizures of temporal lobe origin.

45 cases of partial seizures of temporal lobe origin undergoing sequential EEG investigation first with routine and then methohexitone activated EEG, 31 supplemented by sphenoidal electrodes, are reported. Methohexitone activated foci from temporal lobes which had previously not displayed temporal spike or sharp wave discharges in 15 (33.3%) cases. In 11 (24.4%) this was the first evidence of the focus in 15 (33.3%) cases. In 11 (24.8%) this was the first evidence of the focus in either temporal lobe and in 4 (8.9%) the focus was contralateral to one already seen in routine EEG. In 3 (6.7%) cases the sphenoidal electrodes were essential for demonstrating the focus. Methohexitone evoked temporal spikes or sharp waves irrespective of the nature of the initial routine EEG which was either normal, had non "epileptic" temporal abnormalities or abnormalities outside the temporal region. 2 X 2 chi 2 tests, comparing the frequency with which a particular symptom was accompanied by an EEG in a sequence with temporal discharges, showed that only in the case of evolution to generalised tonic/clonic seizures (secondary generalization) was the association statistically significant: chi 2 4.28, P less than 0.025. Similar testing of length of history and frequency of attacks against the frequency with which temporal discharges occurred failed to establish a statistically significant association.

Adolescent↗

Subacute sclerosing panencephalitis: serial electroencephalographic studies.

A total of 42 EEGs from five patients with subacute sclerosing panencephalitis were studied. Periodic complexes were noticed in 35 (83%) of these. The interval between the complexes shortened in all patients with progression of the illness. The gradual EEG changes may reflect the increasing number of infected cells as well as an on-going accumulation of immature virus structures. The records without complexes were either from the early onset (one record) or terminal stage (six records).

Antibodies, Viral↗

F waves in patients with hand wasting caused by a cervical rib and band.

In five patients with unilateral wasting of the hand muscles as a result of cervical rib and band, F waves were recorded from the hypothenar muscles following stimulation of the ulnar nerve at the wrist. Twelve healthy control subjects were also examined. F-wave latency was consistently increased in the affected hands of the patients, compared with results from the unaffected and control hands. This increase persisted after removal of the cervical band in four patients and was thought to be mainly due to degeneration of fast-conducting fibers. In the fifth patient, F-wave latency decreased after operation, suggesting recovery of a local conduction block in the proximal part of the nerve.

Action Potentials↗