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Biomedical subjects

C H Shatney

Publications and source records attributed to C H Shatney.

87 records · Page 5Linked to original sources
PubMed1976

Effects of intra-arterial ethanol in cardiogenic shock.

Unanaesthetized mongrel dogs in cardiogenic shock received a 30-min intra-arterial infusion of 1 X 9 g/kg of 40% ethanol. Alcohol produced significant vasodilatation and improvements in the mean blood pressure and cardiac output. Arterial pH and the arteriovenous oxygen difference were markedly reduced, and the blood glucose concentration was significantly increased. Despite a considerable reduction in serum CPK levels, survival was not improved by ethanol.

Animals↗
PubMed1976

Effects of prostaglandins in canine endotoxin shock.

Endotoxin shock was produced in healthy, adult mongrel dogs by the intravenous injection of 1.5 mg/kg of E. coli endotoxin. The 24 hour survival of untreated animals was 34% and was not enhanced by volume replacement with low molecular weight dextran. Treatment with dextran and prostaglandin A1 or E1, although effecting significant hemodynamic improvements, did not increase survival.

Animals↗
PubMed1976

Temporal factors in the reduction of myocardial infarct volume by methylprednisolone.

With a canine model of myocardial infarction [ligation of the left anterior descending (LAD) coronary artery] and an intracellular stain for lactic dehydrogenase (LDH) to directly measure size of infarction, the influence of 30 mg. per kilogram of methylprednisolone sodium succinate was evaluted. The intravenous administration of a pharmacologic dose of methylprednisolone one, 2, or 3 hours after the onset of myocardial infarction significantly reduced the ultimate extent of myocardial necrosis, with the greatest reduction seen following the injection of the drug one hour after ligation. The left atrial pressure was significantly decreased by corticosteroid administration, whereas the cardiac index and peripheral vascular tone were improved insignificantly. Inconsistent and/or insignificant effects were observed in the systemic and coronary sinus blood gases and in those indices of myocardial metabolism which were determined. The potential impact of these findings on the clinical applicability of methylprednisolone sodium succinate in acute myocardial ischemia is discussed.

Animals↗
PubMed1975

Prolongation of pancreatic allograft survival by 5-fluorouracil.

Recipient survival in canine pancreatic allotransplantation was significantly prolonged when animals were treated with 5-fluorouracil in combination with low-dose azathioprine. Untreated dogs and those receiving only azathioprine survived for only short periods of time, and pancreatitis was frequently encountered. In contrast, animals treated with 5-fluorouracil were protected from pancreatitis and survived an average of almost three weeks.

Animals↗
PubMedDate not supplied

Metastasis from a pedunculated adenomatous colonic polyp with focally invasive carcinoma: report of a case.

A patient who had metastasis from a focus of invasive carcinoma confined to the head of an otherwise benign pedunculated adenomatous polyp of the sigmoid colon is described. That only 20 such cases have been reported previously attests to the rarity of this phenomenon. Because the morbidity and mortality of radical surgery far outweigh the liklihood of metastasis from such foci of invasive carcinoma in pedunculated adenomatous colonic polyps, local removal is recommended.

Adenocarcinoma↗
PubMedDate not supplied

Management of focally malignant pedunculated adenomatous colorectal polyps.

A hospital record review identified 59 patients whose sole colorectal pathology was a pedunculated, adenomatous polyp with a focus of malignancy confined to the head of the tumor. Thirty-one patients had polyps with in-situ carcinoma, and 28 patients had foci of invasive carcinoma. Sixteen patients who had lesions in situ underwent laparotomy, and not a single instance of metastasis was found. Twenty patients who had carcinoma in situ received only local treatment, and 15 are alive and well. None of the patients treated locally has developed subsequent colorectal cancer, and 12 have survived at least five years following treatment. Of the 28 patients who had invasive carcinoma confined to the head of an adenoma, 19 are alive and well, and 17 have lived five years or more following treatment. There was one instance of lymph-node metastasis, which occurred in a patient who had a malignant lesion extending to the neck of the tumor and tumor cells in the lymphatics in the head of the polyp. All of the eight patients treated locally are alive and well, and five have lived at least five years following treatment. The results of this study, coupled with the rarity of reported metastasis from focally malignant, pedunculated, adenomatous colorectal polyps, strongly suggest that local treatment is sufficient for the vast majority of these lesions. Evidence from the literature suggests that resective therapy should be considered when 1) lymphatics within the head of the polyp contain tumor cells; 2) the cancer is highly undifferentiated; 3) the pedicle is extremely short and malignant changes extend to the neck of the adenoma.

Adult↗