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Biomedical subjects

C H Palmer

Publications and source records attributed to C H Palmer.

9 recordsLinked to original sources

How accurate is fine-needle biopsy in malignant neoplasia of the pancreas?

The accuracy of fine-needle aspiration biopsy of the pancreas in 77 patients was studied, in 47 by the percutaneous route and in 30 under direct vision at the time of operation. Seventeen (49%) of 35 pancreatic malignant neoplasms were detected percutaneously and 13 (65%) of 20 at surgery. The predictive value of a positive test was 100% in both situations. The sensitivity of the percutaneous test was 57%; the sensitivity of the test done at operation rose to 72%. No complications were encountered. The test, when positive, can be relied on in surgical decision making but is of limited value when negative. Our findings are essentially similar to those of others who have reported their experience in the literature.

Adenocarcinoma↗

Malignant lymphoma arising in a large congenital neurofibroma of the head and neck. Report of a case.

A lymphoma developed in a large neurofibroma in a young woman who had no other stigmata of neurofibromatosis. The neurofibroma was congenital and extensively involved the soft tissue and bone of the face and neck. Despite multiple attempts to excise the neurofibroma, it persistently recurred. At the age of 30 the patient underwent another resection of the lesion, and a follicular, mixed, small and large cell lymphoma was present within the neurofibroma. Over 3 years the lymphoma transformed into a diffuse large cell type despite the fact that it remained localized to the neurofibroma. After the lymphoma had transformed, the patient received multiagent chemotherapy. She responded well, and a repeat biopsy showed no residual lymphoma. She is alive and well 25 months after completion of chemotherapy. To the best of our knowledge, this is the first report of a lymphoma arising in a soft tissue neoplasm.

Adolescent↗

Cheyletiella dermatitis.

A mild dermatitis probably due to Cheyletiella yasguri was observed in 2 persons whose pet dog was infested with this parasite. Cheyletiella mites differ morphologically from sarcoptic mites, which cause canine and human scabies. Treatment of man and dog with 1% gamma benzene hexachloride is usually successful in clearing this condition.

Animals↗

Apocrine cystadenoma of the penile shaft.

What is to our knowledge the first apocrine cystadenoma reported on the penile shaft is described. Of 96 previously reported apocrine cystadenomas, more than 90% were located on the face, ears, or scalp; the remainder occurred on the chest, axilla, or prepuce. Apocrine cystadenoma should be considered in the differential diagnosis of solitary blue, gray, or flesh-colored cystic nodules in those areas.

Adult↗

Seroconversion to human immunodeficiency virus (HIV) in hemophiliacs. Relation to lymphadenopathy.

The authors studied the natural history of human immunodeficiency virus (HIV) exposure in 187 hemophiliacs followed for an average of 45 months. Overall, 55 percent developed antibody specific for HIV and 21 percent developed persistent generalized lymphadenopathy. Most patients seroconverted sometime between early 1982 and the end of 1984. Four patients developed acquired immune deficiency syndrome (AIDS) and four seropositive patients developed idiopathic thrombocytopenia (ITP). One of the four patients who developed AIDS and three of the four with ITP had preexisting lymphadenopathy. None of the 10 patients with lymphadenopathy or the 20 asymptomatic patients was seropositive for human T-lymphotropic virus, type I. Although seropositivity and lymphadenopathy have been found in many of the authors' patients, few have developed clinical disease that can be related to HIV infection.

AIDS-Related Complex↗

Quality assurance in mammography: artifact analysis.

Evaluation of mammograms for artifacts is essential for mammographic quality assurance. A variety of mammographic artifacts (i.e., variations in mammographic density not caused by true attenuation differences) can occur and can create pseudolesions or mask true abnormalities. Many artifacts are readily identified, whereas others present a true diagnostic challenge. Factors that create artifacts may be related to the processor (eg, static, dirt or excessive developer buildup on the rollers, excessive roller pressure, damp film, scrapes and scratches, incomplete fixing, power failure, contaminated developer), the technologist (eg, improper film handling and loading, improper use of the mammography unit and related equipment, positioning and darkroom errors), the mammography unit (eg, failure of the collimation mirror to rotate, grid inhomogeneity, failure of the reciprocating grid to move, material in the tube housing, compression failure, improper alignment of the compression paddle with the Bucky tray, defective compression paddle), or the patient (e.g., motion, superimposed objects or substances [jewelry, body parts, clothing, hair, implanted medical devices, foreign bodies, substances on the skin]). Familiarity with the broad range of artifacts and the measures required to eliminate them is vital. Careful attention to darkroom cleanliness, care in film handling, regularly scheduled processor maintenance and chemical replenishment, daily quality assurance activities, and careful attention to detail during patient positioning and mammography can reduce or eliminate most mammographic artifacts.

Artifacts↗