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Biomedical subjects

C H Moore

Publications and source records attributed to C H Moore.

At least 55 records · Page 3Linked to original sources

Reconstruction of right ventricular outflow tract with a valved conduit in 75 cases of congenital heart disease.

Reconstruction of the right ventricular outflow tract with an aortic homograft conduit was performed in 75 patients from 1966 to 1974. The types of congenital heart disease were as follows: pulmonary atresia, 35 cases; severe tetralogy of Fallot, 22 cases; truncus arteriosus, 6 cases; transposition of the great arteries (TGA), 3 cases; single ventricle, 2 cases; and tricuspid atresia, 7 cases. Ninety per cent of the patients had one or more previous shunts, and this was a factor affecting the mortality rate. Other factors included age, pulmonary vascular resistance, surgical anatomy, and technical problems such as bleeding, prolonged bypass, coronary artery injury, and compression of the conduit by the sternum. Our present approach is to avoid shunts, define the anatomy precisely by angiography, and to attempt total correction when severe hypoxia or effort intolerance occurs or before increased pulmonary vascular resistance develops.

Adolescent↗

Analysis of homograft valve failure in 311 patients followed up to 10 years.

Homograft aortic valve replacement was performed in 311 patients at the tnational Heart thospital, London, between 1964 and 1973. Valve failure has occurred in 61 patients (20%), 32 of whom survived reoperation. From 1963 through 1967, 156 valves were freeze-dried and account for 56 of the valve failures. From 1968 to 1973, 118 fresh or fresh-frozen valves resulted in only 5 failures. Six general types of failure have been identified: calcification (13), dehiscence (15), infective endocarditis (17), prolapse (6), cusp degeneration (5), and tear or perforation (5). Valve failure may be due to surgical technical error resulting in dehiscence or valve incompetence, or it may be related to degenerative changes in the homograft. The clinical results, supported by gross and histological examination and viability testing, enable us to conclude that fresh or fresh-frozen valves are superior to freeze-dried valves, having resulted in only 4% valve failure over the past five years.

Aortic Valve↗