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Biomedical subjects

C H Hu

Publications and source records attributed to C H Hu.

At least 73 records · Page 4Linked to original sources
PubMed1987

PUVA treatment of erythrodermic and plaque-type mycosis fungoides. Ten-year follow-up study.

Since our preliminary report of psoralen plus long-wave ultraviolet A (PUVA) therapy in ten patients with erythroderma-type or plaque-type mycosis fungoides (MF), we have treated 38 patients with biopsy-proved MF. Approximately one third, mostly patients with erythroderma, received PUVA as primary therapy; the remainder had recurrent disease following electron beam irradiation or topical mechlorethamine (Mustargen) hydrochloride. Follow-up data are presented in 29 patients who completed an initial course of PUVA given two to three times weekly. A complete clinical response was observed in ten patients with plaque-type MF and seven with erythroderma without Sézary syndrome. The PUVA therapy was palliative for patients with advanced disease, in combination with other therapies. The mean observation period was approximately five years. Despite maintenance PUVA, most patients relapsed between ten and twenty months and were treated with another intensive course. Long-term maintenance therapy with PUVA was necessary to control the disease.

Adult↗
PubMed1985

PUVA-induced melanocytic atypia: is it confined to PUVA lentigines?

Widespread lentigines in fourteen patients following long-term therapy with psoralens and ultraviolet A (PUVA) for psoriasis were documented by biopsy of a representative lesion in a non-sun-exposed site. Chronically PUVA-exposed nonlesional skin was examined in ten of the fourteen patients. Melanocytic atypia consisting of large or angular hyperchromatic nuclei was observed in 57% of PUVA lentigines and 70% of the nonlesional PUVA-exposed skin. Comparison with twenty-four specimens of lentigo simplex or solar lentigines revealed melanocytic nuclear atypia in only two cases. Binucleated melanocytes suggesting disturbed cellular kinetics were seen in all types of lesions examined but most commonly in PUVA lentigines. The presence of giant melanosomes was also a frequent nonspecific finding. Our findings of melanocytic atypia in chronically PUVA-exposed skin, as well as in PUVA lentigines, suggest that both sites are at risk for potential complications of repeated melanocytic stimulation. Whether melanocytic atypia will prove to be a precursor of melanocytic dysplasia or malignancy following PUVA therapy requires long-term evaluation.

Adult↗
PubMed1985

Generalized pustular psoriasis provoked by propranolol.

An 80-year-old man who had had plaque-type psoriasis for 40 years experienced a rapid onset of generalized pustular psoriasis three days after initiation of propranolol hydrochloride therapy. Trial therapy with propranolol on two occasions resulted in similar episodes. The skin lesions and systemic symptoms resolved after the discontinuation of propranolol therapy and administration of methotrexate sodium. This case study documents propranolol--a beta-blocker--as another causal factor for pustular psoriasis.

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