Biomedical subjects
Publications and source records attributed to C H Gold.
The association of systemic amyloidosis with schistosomiasis is rare. This report concerns a 47-year-old Black woman who presented with the nephrotic syndrome, with some unusual features. Ova of Schistosoma haematobium were seen in a rectal biopsy specimen, and amyloid material was shown in renal and hepatic biopsy specimens.
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The prevalence of hypertension, defined as a diastolic blood pressure over 100 mmHg, among young Black women who attended a family planning clinic in Johannesburg, was 2,85%, while in those over 35 years of age it was 8,5%. There was no correlation between hypertension and urbanisation, occupation or urinary sodium output. Within 6 months of diagnoisis, 84% of the women with hypertension had defaulted from the treatment clinic. Family planning clinics can economically screen patients for hypertension, but in this community a separate screening programme would not succeed until patient compliance has improved.
INH pharmcokinetics was studied in 2 groups of patients in chronic renal failure. In the group on conservative treatment, INH half life was prolonged, but was not related to the degree on renal impairement. In the hemodialysis group 73% of the INH given was removed by dialysis within 5 hours. If INH is to be used in the presence of renal failure, individual half life estimations should be performed in order to determine dosage frequency. In patients on hemodialysis, therapy should be given post dialysis. Alternatively, drugs not dependent on renal failure, e.g. rifampicin, may be preferable.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.